Paraneoplastic auto-antibodies and autoimmune disease

Paraneoplastic Antibodies are caused by tumors which express antigens found only in neural tissue. If you look at the types of cancers that have paraneoplastic several have connections to the epstein-barr virus.  This would not be caused by autoimmune cross-targeting.

Epstein-barr (mono) is a herpes virus HHV4 which means it may use estrogen receptors to infect.  In nerves it would use the beta estrogen receptor which cycles to the mitochondria and allows it to hide in nerves. In adrenal cells with estrogen receptors it would cycle to the nucleus and could alter gene expression. It would be interesting to test if all non nerve, non beta receptor, estrogen activating cells trigger the immune system differently. Is it changed gene expression or the HHV4 virus.

This is a noticeable correlation not proven.

Thymoma and epstein-barr
http://www.ncbi.nlm.nih.gov/pubmed/2837902

Hodgkin's and epstein-barr
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1186979/

Breast carcinoma and epstein-barr
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078605/

(For Hodgkin's) the B cells express the estrogen receptor which the EBV uses
http://www.ncbi.nlm.nih.gov/pubmed/12070310

Burkitt's lymphoma is proven to be caused by epstein-barr

Note that the tumors will generate the auto-antibodies but these antibodies should not be able to get into the brain unless a hole in the blood brain barrier exists.  Larger infections can make holes: T.gondii, mycobacterias, strep, sutterella....if a hole exists I think gluten sensitivity occurs.

Further note that the oral herpes virus has been found to be inhibited by lysine and encouraged by arginine.  There is no evidence to support epstein-barr HHV-4 acts like HHV-1 but one could try.

http://www.ncbi.nlm.nih.gov/pubmed/640102
http://www.ncbi.nlm.nih.gov/pubmed/6262023

No Epstein-barr vaccine is available
http://www.boston.com/news/health/articles/2008/10/06/why_is_there_no_vaccine_against_infectious_mononucleosis/

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease.  The immune system is instructed to destroy both the inside and the outside of the target.

Do the antibodies entering the brain trigger an autoimmune attack on a part of the brain?

In this case the viral trigger is further away but still marking the target?

http://angelabiggs.blogspot.com/2015/02/over-view-of-brain-autoimmunity.html

Is ALS triggered by autoimmune cross-targeting? Trichophyton involved? added Keratin comments

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease.  The immune system is instructed to destroy both the inside and the outside of the target.

Is ALS cross-targeting on the anterior horn cells? An enterovirus on the inside and trichophyton on the outside?

ALS and the poliovirus similarities
http://www.ncbi.nlm.nih.gov/pubmed/7611634

Enterovirus and ALS
http://www.ncbi.nlm.nih.gov/pubmed/19900148
http://www.webmd.com/brain/news/20000113/could-virus-cause-lou-gehrigs-disease
http://www.ncbi.nlm.nih.gov/pubmed/9021257
http://www.ncbi.nlm.nih.gov/pubmed/15208080


https://books.google.com/books?id=jjvFj6aQeMgC&pg=PA315&lpg=PA315&dq=virus+ALS&source=bl&ots=gTQCdz7kl7&sig=QtiMKeHVDsScRBdZK8fnkIXTirI&hl=en&sa=X&ved=0CDIQ6AEwAzgUahUKEwjnze-38tXHAhVLpIgKHb3MBpg#v=onepage&q=virus%20ALS&f=false

note that some researchers can't find the enterovirus in ALS patients?
http://www.ncbi.nlm.nih.gov/pubmed/15111658

What would the larger infection be Trichophyton?

 Trichophyton has a wood rot variety.  This could be found in rotting beaver dams....which might explain the ALS clusters around lakes in north America.
http://link.springer.com/article/10.3839%2Fjksabc.2010.026#page-1

Can infections of the feet explain the sport association of ALS? Lou Gehrig's disease
 Trichophyton is the most common skin fungus and causes athletes foot.
http://www.ncbi.nlm.nih.gov/pubmed/18578874

Als and scalp issues: a forum's comments
http://www.alsforums.com/forum/archive/index.php?t-1141.html

trichophyton and the scalp
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1521225/
http://www.ncbi.nlm.nih.gov/pubmed/25322706

Pick's disease and ALS
http://www.ncbi.nlm.nih.gov/pubmed/3322801
http://www.ncbi.nlm.nih.gov/pubmed/21369423
http://www.ncbi.nlm.nih.gov/pubmed/8410013
http://www.ncbi.nlm.nih.gov/pubmed/15068178

Picks is in the frontal and temporal lobes and involves Tau

Hyperphosphorylated Tau has been found in ALS
http://www.ncbi.nlm.nih.gov/pubmed/16769962
http://www.ncbi.nlm.nih.gov/pubmed/17713769

Other thoughts:
ALS skin changes
http://www.ncbi.nlm.nih.gov/pubmed/3714056
http://www.ncbi.nlm.nih.gov/pubmed/2769298

ALS itchy skin
http://www.alsforums.com/forum/general-discussion-about-als-mnd/15654-itchy-skin.html

could this be a sign of nerve damage at the skin starting the disease?

Currently they are studying the ability of Keratin to stimulate nerve growth
http://www.news-medical.net/news/20101202/DOD-awards-24224-million-grant-to-study-keratin-gel-in-peripheral-nerve-regeneration.aspx

This fungus destroys toenails too.  I feel like we are missing something here about the fungus and it marking the outside of these nerves perhaps because of keratin?

The skin's hairs are embedded in a layer of skin nerve cells which are unmyelinated....so is it an autoimmune attack starting at these nerves? which turns into motor neurons?

ALS and neuronal filaments
http://www.sciencedirect.com/science/article/pii/S0925443906001761

Bunina bodies, the tau we see, does it appear because of a neurofilament issue with this fungus?

Can coconut oil slow Trichophyton growth?
http://www.ncbi.nlm.nih.gov/pubmed/1302812
http://www.ncbi.nlm.nih.gov/pubmed/8264720

Please see newer posts 2016....ALS might not be autoimmune but could be related to an aflotoxin-like compound and Tau.
http://angelabiggs.blogspot.com/2016/03/microtubule-disease-issues-aflotoxin.html

Autoimmune Cross-targeting and periodontal disease

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease.  The immune system is instructed to destroy both the inside and the outside of the target.

autoimmune myocarditis and periocarditis
http://www.ncbi.nlm.nih.gov/pubmed/26197653

oral virus: human pailloma virus : hpv
http://www.medicalnewstoday.com/articles/247497.php

woman with HPV have increased heart problems
http://www.ncbi.nlm.nih.gov/pubmed/22032713
http://www.medicalnewstoday.com/articles/236624.php

mycobacteria is in lungs, spleen, liver...heart?

mycobacteria contaminating heart transplants
http://www.ncbi.nlm.nih.gov/pubmed/12123216
http://www.ncbi.nlm.nih.gov/pubmed/2398429
http://www.ncbi.nlm.nih.gov/pubmed/23176090

mycobacteria and heart disease
http://www.ncbi.nlm.nih.gov/pubmed/15082105

crohn's and heart disease
http://www.medscape.com/viewarticle/550992

crohn's and gingivitis ...a mycobacteria?
http://www.ncbi.nlm.nih.gov/pubmed/24216685

mycobacteria and crohn's
http://www.ncbi.nlm.nih.gov/pubmed/12901893
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718892/
http://journal.frontiersin.org/article/10.3389/fimmu.2015.00096/abstract

metabolic syndrome and periodontal disease
http://www.ncbi.nlm.nih.gov/pubmed/24007401
http://www.ncbi.nlm.nih.gov/pubmed/25469423

Metabolic syndrome and mycobacteria
http://www.ncbi.nlm.nih.gov/pubmed/18448263

psoriasis is linked to heart disease and strokes
http://www.webmd.com/skin-problems-and-treatments/psoriasis/news/20100315/psoriasis-linked-to-heart-disease-cancer

psoriasis and mycobacteria

Does Autoimmune Cross-targeting trigger Addison's disease?

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease.  The immune system is instructed to destroy both the inside and the outside of the target.

Autoimmunity and the adrenal glands
http://www.ncbi.nlm.nih.gov/pubmed/26240101
triggered by the flu virus?

addison's and the flu
http://www.ncbi.nlm.nih.gov/pubmed/4698728
http://www.ncbi.nlm.nih.gov/pubmed/13985224
http://www.ncbi.nlm.nih.gov/pubmed/26240101

That would mean the adrenal glands had D2 receptors

D2 receptor and the adrenal glands
http://www.ncbi.nlm.nih.gov/pubmed/11549694
http://www.ncbi.nlm.nih.gov/pubmed/2960326

What would be the larger infection on the outside of the adrenal glands?

Primary infection of adrenal glands tends to be fungal infections:
http://www.ncbi.nlm.nih.gov/pubmed/14513986
http://www.uptodate.com/contents/causes-of-primary-adrenal-insufficiency-addisons-disease

Polyglandular syndrome one vs 2

 APS 1 involves children and candida
APS 2 involves adults, no candida which means other fungal infections?, more women than men, addison's

Both have hypothyroid associated

APS 2 is also called Schmidt's syndrome
which can also be associated with scarcoidosis
http://www.ncbi.nlm.nih.gov/pubmed/8935608

Scarsoidosis is increasingly connected to fungal infections
http://www.ehjournal.net/content/10/1/8
http://annals.org/article.aspx?articleid=676878

Cross-targeting autoimmunity and autoimmune ovarian failure

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease.  The immune system is instructed to destroy both the inside and the outside of the target.

human papilloma virus vaccine and  autoimmune ovarian failure
I think the virus itself would trigger the disease by marking the inside of ovarian cells
http://www.ncbi.nlm.nih.gov/pubmed/23902317
http://www.ncbi.nlm.nih.gov/pubmed/24468416

chlamydia and ovarian failure: I think this bacteria marks the outside of the ovarian cells
http://www.fertilitysolution.com/Latest-Research/Premature-Ovarian-Failure-Associated-with-Chlamydia.html is it curable?

chlamydia and fertility
http://www.ncbi.nlm.nih.gov/pubmed/10582782
http://www.ncbi.nlm.nih.gov/pubmed/3761270
This infection causes inflammation and increases the rate of etopic pregnancies alone not ovarian failure until cross-targeting occurs

I am thinking that the only ones who develop the autoimmune ovarian failure have both infections or get the vaccine on top of a chlamydia infection.

In fact if you get the vaccine before any chlamydia infections i would think it would be protective for life.
In this study they found no increased rates of autoimmune disease after vaccination of young girls. (probably without chlamydia infections)
http://www.ncbi.nlm.nih.gov/pubmed/24206418

Rheumatic Fever autoimmunity as cross-targeting

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease.  The immune system is instructed to destroy both the inside and the outside of the target.

Strep and coxsackie causing rheumatic fever together...already proven in the heart?
http://www.ncbi.nlm.nih.gov/pubmed/18608177
http://www.ncbi.nlm.nih.gov/pubmed/25191648
http://www.ncbi.nlm.nih.gov/pubmed/8244506
http://www.ncbi.nlm.nih.gov/pubmed/227971
http://www.ncbi.nlm.nih.gov/pubmed/10021888
http://medind.nic.in/imvw/imvw17247.html
http://www.ncbi.nlm.nih.gov/pubmed/2561125

sydenhams chorea which is the rheumatic reaction in the brain (is this cross-targeting too?)
http://www.ncbi.nlm.nih.gov/pubmed/24184556

coxsackie and the basal ganglia
http://www.ncbi.nlm.nih.gov/pubmed/3425221

strep and the basal ganglia
http://www.ncbi.nlm.nih.gov/pubmed/22617826

Is narcolepsy triggered by autoimmune cross-targeting?

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease.  The immune system is instructed to destroy both the inside and the outside of the target.

Narcolepsy has been considered as autoimmune possibly triggered by infections but the focus was on molecular mimicry
http://www.ncbi.nlm.nih.gov/pubmed/21963829

The dorsal raphe nucleus cells would be the target for Narcolepsy and the inside of the cells would be marked by the flu virus while the outside would be marked by the strep.

Narcolepsy and strep
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786037/
http://www.ncbi.nlm.nih.gov/pubmed/23493659
http://www.ncbi.nlm.nih.gov/pubmed/19725248

Narcolepsy and the flu virus H1N1
http://www.ncbi.nlm.nih.gov/pubmed/24559657
http://www.ncbi.nlm.nih.gov/pubmed/24551456
http://www.ncbi.nlm.nih.gov/pubmed/26216616
http://www.ncbi.nlm.nih.gov/pubmed/24849861