Dermatitis Herpetiformis, Celiac, and E.coli ...caused by cross-targeting autoimmunity?

Autoimmune Hypothesis:
Cross-targeting of the immune system by a viral infection marking the inside of a host cell and second infection marking the outside of the host cell causes autoimmune disease where the organ is attacked.  In the case of Celiac disease: Antibodies against e.coli mark the outside of the intestine then an intestinal virus (mono or hepatitis) infection marks the inside of the intestinal cells.

If celiac disease is e.coli then what about Dermatitis Herpetitformis?

Dermatitis Herpetiformis has been correlated with Celiac.  25% of patients with Celiac disease have  HD.
http://celiac.nih.gov/Dermatitis.aspx

D. herpitiformis and  thesmall intestine's bacteria
http://www.ncbi.nlm.nih.gov/pubmed/4210511

E.coli causes small intestine infections
http://www.pathologyoutlines.com/topic/smallbowelEcoli.html

 The e.coli of bladder infections is the same e.coli of skin infections
http://jcm.asm.org/content/47/6/1811

 Bladder Infections and celiac disease in children
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1511510/

Celiac viral infections: hepatitis and adenoviruses (mono)
http://www.sciencedirect.com/science/article/pii/S1568997208002012
http://www.ncbi.nlm.nih.gov/pubmed/25212692
http://www.ncbi.nlm.nih.gov/pubmed/15492610
http://www.ncbi.nlm.nih.gov/pubmed/23982094

Celiac disease found in hepatitis patients
http://www.ncbi.nlm.nih.gov/pubmed/15645466

This page is still under construction...See previous post of mine: Celiac disease as an autoimmune disease where e.coli is connected to gluten through dimorphic switching.

http://www.blogger.com/blogger.g?blogID=2399123431411408462#editor/target=post;postID=5260289305288915498;onPublishedMenu=posts;onClosedMenu=posts;postNum=44;src=postname

Pick's disease, ALS. and microscopic colits

Autoimmune Cross-targeting hypothesis: that 2 infections exist on a target triggering the autoimmunity.  One viral infection marks the inside while another infections marks the outside.

Link to newer review post
http://angelabiggs.blogspot.com/2015/02/over-view-of-brain-autoimmunity.html

Pick's disease and ALS
http://www.ncbi.nlm.nih.gov/pubmed/3322801
http://www.ncbi.nlm.nih.gov/pubmed/21369423
http://www.ncbi.nlm.nih.gov/pubmed/8410013
http://www.ncbi.nlm.nih.gov/pubmed/15068178

Tau with ALS
http://www.neurology.org/content/66/11/1770.abstract

AlS associated protein found in Pick's
http://www.ncbi.nlm.nih.gov/pubmed/23888880

  Can infections of the feet explain the sport association of ALS? Lou Gehrig's disease
 Trichophyton is the most common skin fungus and causes athletes foot.
http://www.ncbi.nlm.nih.gov/pubmed/18578874

 Trichophyton has a wood rot variety.  This could be found in rotting beaver dams....which might explain the ALS clusters around lakes in north America.
http://link.springer.com/article/10.3839%2Fjksabc.2010.026#page-1

I keep wondering if trichophyton is a type of blastomyces....able to cross the blood brain barrier. http://www.ncbi.nlm.nih.gov/pubmed/9703159
or does it need help? obviously people can have ALS and not pick's....does it require strep or a mycobacteria to make the path to the brain?

The intestinal condition of colitis fits with the other fungal infections (Candida and Saccharomyces) causing colitis which is why I am looking for a fungus in ALS.  I am considering hemorrhoids but i have no evidence.

In addition to not being gluten and casein sensitive it must not have the insulin-like factor.
ALS does not have diabetes associated with it. (candida causing microscopic colitis does have type 1 associated with it) This is another way to determine  that the other fungal infections do not cause ALS even if they all look like microscopic colitis.
 Pick's disease involves Tau proteins in the frontotemporal lobe. This is very different from the parkinson's and alzheimer's which may have connections to mycobacterias.

Here is a case where the person had an ALS diagnosis but it wasn't and gluten free solved it. http://www.youtube.com/watch?v=Wliz6Gbg4fE

 Prediction of ALS associated with Hashimoto's thyroid....looking for references now
only personal posts right now http://treato.com/ALS,Hashimoto%27s+Disease/?a=s 

reference als and hashimoto's
http://users.otenet.gr/~dkount/oldpage/8-1.htm

Alzheimer's, parkinson's,Tourettes: How do they overlap?

Alzheimer's I have been viewing as a mitochondrial disease where the nerve gets stuck in growth mode attempting to call mitochondria down the nerves axon.  Mothers of down syndrome children tend to get the early form of Alzheimer's disease. Down syndrome is caused by malfunctioning mitochondria not making enough ATP for dividing the chromosomes correctly.  Without decent ATP levels the mitochondria do not move correctly.

The herpes virus (cold sore) has recently been discovered to cause mitochondrial dysfunction.  The mitochondria do not move where they are suppose to. In 2011 the herpes virus was associated with Alzheimer's disease.  Infecting the neurons in question.
ref
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1796774/
http://www.sciencedaily.com/releases/2011/04/110404122203.htm

So the question is: How did the virus get past the blood brain barrier?  Everyone with cold sore herpes does not have dementia.

Type 2 diabetes has been associated with Alzheimer's disease.  I have postulated that some type 2 diabetes maybe caused by mycobacterias. So perhaps a mycobacteria has broken the blood brain barrier.  Something must be involved in breaking the BBB like strep or t.gondi or a mycobacteria in order for the herpes virus to get into the brain.

Mycobacteria has been debated: http://www.ncbi.nlm.nih.gov/pubmed/10426143

Parkinson's I have associated with mycobacteria and avian flu/flaviviruses possibly causing an autoimmune disease by cross-targeting.  Do Parkinson's patients who develop Alzheimer's have the herpes virus on top? The mycobacteria breaking the BBB allowing both viruses to sneak through a hole for both diseases?

Tourettes I was considering strep followed by a herpes virus. I am reconsidering now.  Do all Tourettes patients develop Alzheimer's ? Strep breaks the blood barrier. This does not make sense because Tourettes patients tend to have enhanced memory skills.  Is alzheimer's only caused by mycobacteria because strep rarely is infecting a patient long enough to allow herpes across and when it does tourettes results instead?

reference of Strep in brains cells and autoimmunity to brain cells in Tourettes or is this Pandas?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1174655/  

reference of herpes and Tourettes
http://www.ncbi.nlm.nih.gov/pubmed/3195682

Must mycobacteria be involve with the herpes virus for Alzheimer's to develop? Tourettes with just strep and herpes infections will only have the autoimmune triggered tics? Or is tourettes so genetic that it only needs strep?  you would think the herpes could cross over and do damage causing Alzheimer's which we do not see.....Tourettes patients tend to have brilliant memories. 

2015 update Tourettes is Genetic while pandas which is tourettes like is autoimmune? http://angelabiggs.blogspot.com/2015/02/over-view-of-brain-autoimmunity.html

Cross-targeting means:
 A first infection marks a target with antibodies on the outside and then a virus marks the inside of a target to the immune system. Hypothesis is that cross-targeting triggers autoimmune disease.

I believe that Alzheimer's is not an autoimmune disease rather a mitochondria dysfunction while parkinson's and Pandas are autoimmune. Maybe?

Could this overlap of infectious culprits explain some of the  overlap we see in some patients with Alzheimer's disease? Could herpes be destroying the mitochondria of some elderly causing some cases of Alzheimer's but the patients can later develop parkinson's because it was a mycobacteria the opened the blood brain barrier?   This means there is no order to Parkinson's or Alzheimer's concerning mycobacteria. one could even get parkinson's first?

Where syn and amyloid plaques appear together mycobacteria exists? With Parkinson's as an autoimmune disease of cross-targeting between a mycobacteria and avian flu/west nile? Can we get syn build up before the autoimmunity? before the parkinson's even if just mycobacteria is there?

Do mothers of down syndrome children have the amyloid plaques? When are the plaques not there? Are they a sign the mitochondria can't move and all Alzheimer patients will have some? But the dementia is really the inability of the mitochondria to move? Obviously their mitochondria has malfunction and herpes did not have to be involved.  Again Alzheimer's would be a mitochondria moving disease.

Can the t.gondi of schizophrenia allow the herpes virus across? Notice a theme of larger infections creating the holes allowing viruses to slip through.

I will research this and post references soon. This page is still under construction. (it is a tad confusing at the moment )

Other things that need to be tied in: the diacetyl link to Alzheimer's disease.  Used as the artificial butter in popcorn and margarine it is also the undesirable butterscotch taste in beer.  The mitochondria of S. cerevisiae make diacetyl during the early stages of fermentation.  My suspicion is that since it comes from a mitochondria....it will interfere in high levels with the function of mitochondria in some kind of negative feedback loop.  Thus the popcorn and alcohol dementia are caused by malfunction mitochondrias not moving?  I really hope this is not true. I can't give up my quality beer or wine....honestly i might choose some mental loss later. Or at least hope that it is really just when overdoses and drinking in moderation is fine....we can hope.  My bet is that extremely high doses are required. That or i have to switch to Red Wine.

diacetyl in popcorn and Alzheimer's
http://www.cbsnews.com/8301-504763_162-57489905-10391704/diacetyl-chemical-in-artificial-butter-popcorn-linked-to-alzheimers-plaque-build-up/

So what might be true...herpes with mycobacteria cause mitochondria dysfunction but alone they may not? Or is it that Tourettes is only a genetic attack on the basal ganglia once strep has broken the barrier regardless of herpes....and herpes only makes things worse later for the Tourettes patient.  And herpes just needs to cross the blood brain barrier (a hole made by any of the infections that can ) in order to cause the mitochondria to malfunction.....maybe?

Schizophrenia which could be an autoimmune attack caused by t.gondi breaking the blood brain barrier has had issues with dementia. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1737362
Could these be the patients with the herpes (cold sore) viruses?

update herpes and schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/15319094

Anyone else have thoughts on this?  Is this possible?

alpha-synuclein and parkinson's

If...and that is a huge if...parkinson's has mycobacterias as part of the causation then how do we end up with alpha-synuclein plaques?

(Parkinson's could be cross-targeting of mycobaterias and avian flu)
 http://angelabiggs.blogspot.com/2013/06/autoimmune-basal-ganglia-from-2.html

We know that Mycobacterias use/eat glutamate and it is routinely used as a component of growth plates.

What if....syn which is involved with the vesicles and secretions of Glutamate by neurons is precipitating in parkinson's disease thus forming the signature synuclein plaques because the demand for glutamate  has increased? more transport vesicles moving the glutamate....extra synuclein proteins...neurons  stuck in secretion mode.

Alpha-synuclein is increased in Parkinson's verse Alzheimer's
http://www.ncbi.nlm.nih.gov/pubmed/23362176 

Over expression of synuclein in mice looks like Parkinson's
http://www.sciencedaily.com/releases/2013/06/130607160329.htm

The amount of glutamate does appear to be increased in Parkinson's disease patients. 
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030918

They say that Rifampicin which is a antibiotic against mycobacterias interferes with synuclein  expression by interfering with the synthesis of RNA.....it could be helping parkinson's patients more then we realize.....if mycobacterias are instigators of the disease itself.

This could be too far fetched to be real.....but if mycobacterias are in the brain are they attached to the neurons? is it the immune system attacking the nerves?

 Alcoholics have increased synuclein and they do not have parkinson's but can have parkinson's like symptoms. Alcohol causes an increase in GABA release and a decrease of glutamate.  which means the issue is not so much glutamate but synuclein...which is part of the release vesicle.  
 http://www.ncbi.nlm.nih.gov/pubmed/15897720

(glutamate is the green light stimulation transmitter while the GABA is the red light calming nerves)

Not all alcoholics have parkinson's features. Not all mycobacteria infected people have parkinson's....so it still comes down to our own immune system cross-targeting.

The avian flu under suspicion as a Parkinson's trigger increases the expression of synuclein.  Proving that the virus was in the neurons involved.  http://www.ncbi.nlm.nih.gov/pubmed/23851655 

Imagine the outside of the brain cell clutched by a mycobacteria and the inside infected by the flu...even after the infections are gone the immune system has cross-targeted the nerves..the ones with extra synuclein.

Is parkinson's a state where the immune system  does not stop with the infection but continues because of the autoimmune cross-targeting...stuck in a state of inflammation?

immune myelitis after hepatitis B vaccine

The hypothesis up until now has been that autoimmune attack is triggered by the cross-targeting of an infection like a bacteria/fungus then a viral infection.

Anti-insulin marking the pancreas then the flu virus infecting and replicating there causing the immune system to attack the pancreas and causing type 1 diabetes (just one example)

It is baffling then to read that after a hepatitis B vaccine that some kids develop myelitis which is a swelling of the spinal cord.

Hepatitis B is an infection of genital secretions, the blood, the bloods filter the liver....liquid based cells.  How does it cause antibodies to the central nervous system?

The only cross over I can fathom is one between Herpes HSV-2 and Hepatitis B as sexually transmitted diseases of the genitals. Here the location is the same and the immune system could get confused if the infections coexisted.

Then later when a hepatitis B vaccine is received the body would look not just for hepatitis but for herpes.....

note that it is not the vaccine that causes autoimmunity but the virus piece itself in the vaccine and the industry has pulled any vaccine that has reactions....the true trigger is the virus. I  advocate vaccinations.

The chicken pox virus aka vericella zoster virus incubates in the spinal cord.  The varicella zoster virus is the human herpes virus 3 based on homology.  To our immune system it is a herpes virus

Hypothesis:  If there is a history of genital herpes and hepatitis in the mother....and the child has had chickenpox (not the vaccine the actual disease)....then and only then could hepatitis vaccine could trigger myelitis in the child.

Antibodies can cross the blood barrier if the zoster virus (chicken pox virus) has already created holes and crossed. 

Possible? CDC will have to check case histories here.

Asperger's, Sjogren's, and Hashimoto's overlap?

Autoimmune Cross-targeting hypothesis:  The immune system triggers autoimmunity because two infections exist on one target.  One viral inside the target and one visable...like a fungus or bacteria on the outside of the target.

Candida seems to be the candidate for Sjogren's first infection which creates the first antibodies.  Then Hepatitis C virus or epstein barr seems to be the viruses that are involved in the cross-targeting triggering causing Sjogren's autoimmune attack at the lymphocytes.

 Hepatitis C and eptsein barr infect lymphocytes. Candida infects skin, mouth, eyes, lymph, bones, and joints.  The overlap target looks like the lymphocytes.

While I was researching the cross-targeting of Sjogren's this pattern emerged: Asperger's overlapping  Sjogren's and Hashimoto's.

Mother with Sjogren's, son with Asperger's? Or son had early diagnosis of thyroid disorder?
 Several forums...looking for a CDC study. If I can't find this I will request one.

Sjogren's with Hashimoto's  thyroid
http://www.ncbi.nlm.nih.gov/pubmed/23884987
http://www.ncbi.nlm.nih.gov/pubmed/16984944
http://www.ncbi.nlm.nih.gov/pubmed/8422556
http://www.ncbi.nlm.nih.gov/pubmed/9010968

Aspergers's with Hashimoto's thyroid? do they have low TSH causing OCD?
Asperger's have a form of obsessive compulsive disorder but it manifests differently then the tourettes form.
http://www.ncbi.nlm.nih.gov/pubmed/17354567

I had associated fungal infections or strep with Hashimoto's with the low Thyroid stimulating hormone TSH possibly triggering repetitive behavior.

Not associated with repetitive OCD behavior but rather ones kidneys is restless leg syndrome.

Restless leg syndrome with Asperger's
http://www.ncbi.nlm.nih.gov/pubmed/20738960
http://www.ncbi.nlm.nih.gov/pubmed/15450915

Restless leg syndrome with Sjogren's
http://www.ncbi.nlm.nih.gov/pubmed/8252317
http://www.ncbi.nlm.nih.gov/pubmed/17977584

The restless leg could be because of Kidney issues: http://www.ncbi.nlm.nih.gov/pubmed/15165541
Sjogren has been associated with kidney issues: http://www.ncbi.nlm.nih.gov/pubmed/23557013

So if a patient with Asperger's experiences restless legs is it the kidneys just like sjogren's?
Okay just to be cute I will post this: http://www.ncbi.nlm.nih.gov/pubmed/15079170
(i just went to Italy and Michelangelo is still on my mind)


Candida and type 1 diabetes exists for Sjogren...does type 1 diabetes appear in Asperger's?
Is this one type of Candida in particular that can lead to Asperger's?

Note that Asperger's was first diagnosed in 1944 which is a few years after the start of antibiotics.

Sjogren has IBS, does Asperger's have IBS? Irritable bowel syndrome

Forgive the sketchy outline I am starting with....I will update this as soon as I can.
 This theory also still fits with my earlier asperger's post....sjogren overlaps with type 1 diabetes and Candida.

Vitiligo which is the lack of pigment has been associated with Addison's disease. Addison's disease I associate with Candida, viral, and genetic susceptibility. Here is a website where someone is trying to directly link candida and vitiligo: http://blog.probacto.com/vitiligo-and-candida-connection/ 

Here is a paper linking sjogren and vitiligo
http://www.pagepress.org/journals/index.php/rr/article/view/rr.2009.e7/1393

Candida makes a melanin pigment: http://ec.asm.org/content/9/9/1329.full 
Thus if the immune system was after candida and melanin...it could confuse melanin and melanocytes....thus the vitiligo.

  I am bringing this up wondering if pigment issues appear in Asperger's and how much of an overlap exists between albino issues and Asperger's.  Deafness can occur with albino's...can deafness occur from on autoimmune attack on melanin.

I found a personal blog by a mother named Nell with an asperger's child who noticed a huge improvement when her child had gone on Anti-virals.  (vira-stop) Her son Julian had tested for extremely high levels of epstein-barr virus.

Epstien-barr virus is a culprit underconsideration by researchers as an instigator of melanoma...this virus infects melanocytes.  It seems very likely to  me that this could be the cross-targeting that causes Asperger's to be an autoimmune disease.  Candida makes anti-melanin antibodies that focus on melanocytes but our immune system won't attack until a virus also marks it....it is then possible that melanin used in other areas of the the body could be attacked.  Because hearing involves melanin the immune system could cause deafness....some areas of the brain have melanin....but the blood brain barrier must develop a hole....i am not sure how this will develop but at least we have a starting place.

The top most part of the brainstem the mesencephalon is made up of the tectum and the cerebral peduncles. The cerebral peduncles are nerve fibers that carry melanin. Is this area of the brain vulnerable to antibodies or does the blood brain barrier protect it?  Would an autoimmune attack on melanin involve these nerve fibers?  This is the region of the brain for processing the control of eye movements and auditory input.... and quick responses.

As for the cross-targeting Epstein-barr has been known to infect the brainstem region and cause encephalitis. http://www.ajnr.org/content/27/7/1447.long

I have read that asperger's can coexist with dyslexia and that some asperger's kids have coordination issues.  Could this explain what is going on? would immune suppression help? I have them as different groups.

Is Asperger's an autoimmune disease of melanin containing tissue/nerves of the brainstem?  Candida/aspergillus causing antibodies marking the target then the epstein-barr virus infecting the target?





NONE of this could be true..hypothesis...but my imagination can't help but generate possible connections like this for us to look at.  I hope my thoughts help research.

Bipolar disorder is not autoimmune but it could be caused by Graves which is autoimmune

Most of this Blog focuses on an autoimmune hypothesis where 2 infections cross-target on a cell type then autoimmunity develops.

When I looked at bipolar I realized it was not itself autoimmune but from autoimmune thyroid disease not under control.  Thyroid issues need to be identified quickly and continuously monitored so health does not become worse.

Bipolar disease patients have increased monoamine neurons in their brains. Thyroid hormones are involved in the development and regeneration of brain cells. http://www.ncbi.nlm.nih.gov/pubmed/?term=monoamine+bipolar+neurons+Zubieta

Graves disease which is a hyper thyroid disorder where excess thyroid hormone is produced. Bipolar patients have a history of Graves disease. (references coming soon page under construction still)
http://www.ncbi.nlm.nih.gov/pubmed/22842504
http://www.ncbi.nlm.nih.gov/pubmed/22520715
http://www.ncbi.nlm.nih.gov/pubmed/15763125
http://www.ncbi.nlm.nih.gov/pubmed/16271661

Graves disease I have as an autoimmune disorder connected with the mycoplasma infection group: RA, LUPUS, chronic asthma, and some type 1 diabetes.
http://www.ncbi.nlm.nih.gov/pubmed/?term=mycoplasma+graves 
http://www.ncbi.nlm.nih.gov/pubmed/11128659
http://www.ncbi.nlm.nih.gov/pubmed/8943749

Unlike schizophrenia where infections have a direct involvement triggering the autoimmunity to the brain, bipolar I believe is a result of the hyper thyroid.....autoimmunity at the thyroid not at the brain. The thyroid telling the brain cells to grow in excess.

This fits with my theory of Alzheimer's and growth.  Thyroid stimulating hormone receptor is over expressed in the brain of patients with Alzheimer's and Down syndrome, those with mitochondrial defects where neuron growth would be stifled and the brain would attempt to over ride the system and increase growth.  (I have suggested that the APP protein is a growth-on serine protease encouraging neuron growth)

Overlaps and misdiagnosis of the elderly between Bipolar and Alzheimer's disease has occurred because of an overlap in memory loss and mood swings.  Perhaps by comparing these 2 different diseases we may figure out how they work faster...giving clues to the normal functioning system and revealing how the thyroid controls brain cell growth.

Another interesting tangent has to do with Hypothyroid, Hashimoto's disease. What if OCD was linked to the hypothyroid condition...I am looking for references to confirm.  Genetically altered mice with a point mutation in the receptor for thyroid stimulating hormone had less of the neurons and developed repetitive movement disorders.  http://www.ncbi.nlm.nih.gov/pubmed/11530227  Autoimmune hypothyroid I have weakly linked to the fungal infections like aspergillus and candida. 

Strep has been associated with OCD which made me wonder if it effected the thyroid: yes it does. http://www.ncbi.nlm.nih.gov/pubmed/23435638 Streptococcus anginosus infections suppressed the TSH of the thyroid in both of these patients.

The other interesting overlap I have stumbled upon here: stuttering & low TSH.  Autistic kids given the Alzheimer's drug Memantine started stuttering....which makes me think that Memantine is not just a NMDA receptor antagonist but a TSH receptor antagonist.....? 

I hope these thoughts spark research, hope, and stop the worsening of biopolar or OCD in patients.
Angela Biggs