Hypotheses: Autoimmune Cross-targeting, Co-carcinogenesis, and Quorum complications : April 2015

Monday, April 27, 2015

Drug induced autoimmunity could be cross-targeting autoimmunity

Drug induced lupus is when the muscles are targeted by the immune system
http://en.wikipedia.org/wiki/Drug-induced_lupus_erythematosus

Autoimmune liver disease produces anti-muscle antibodies marking the outside of the muscles
http://en.wikipedia.org/wiki/Anti-smooth_muscle_antibody

Hydralazine is a smooth muscle relaxant and goes inside of muscles (so instead of a virus marking the inside of the muscle it is hydralazine)
http://en.wikipedia.org/wiki/Hydralazine

Monocycline which is an antibiotic for acne appear to also get inside of muscles hence the muscle cramps of the patients taking the drug again replacing the virus for marking the inside

Drug induced Hemolytic anemia has the reverse scenario where the drug is marking the outside of the red blood cells
http://en.wikipedia.org/wiki/Autoimmune_hemolytic_anemia

Red blood cells become coated with penicillin
http://asheducationbook.hematologylibrary.org/content/2009/1/73.full

The virus in this case is hepatitis C (or any other virus that can infect red blood cells...they can try but red blood cells have no nucleus or mitochondria to replicate in)
http://www.ncbi.nlm.nih.gov/pubmed/11799634

Another option would be a bone marrow virus like RSV
http://www.atsjournals.org/doi/full/10.1165/rcmb.2010-0121OC#.VT8EySFViko
a virus changing what is on the inside before it becomes a Red blood cell

RSV and anemia associations
http://www.sciencedirect.com/science/article/pii/S1201971213000544

Friday, April 24, 2015

fish allergy and yersinia infections?

Friday, April 17, 2015

Can some paralysis be caused by an autoimmune attack?

Cross-targeting autoimmune hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease. The immune system is instructed to destroy both the inside and the outside of the target.

Staph can be found along the nerves of the spinal cord. Has staph been linked to paralysis? Are some of them cross-targeting autoimmune diseases?

I wanted to connect D68 with staph infections making the paralysis an autoimmune disease.
Staph is in the right place. D68 is an enterovirus like polio.

paralyzed legs from staph infection (shows it infects the spine)
http://www.wpxi.com/news/news/health-med-fit-science/mother-paralyzed-after-developing-staph-infection-/nkqZR/

spinal cord abscess is typically staph (infects the spine)
http://www.nlm.nih.gov/medlineplus/ency/article/001405.htm

Then the 68 infects the spinal cord cells from the inside.

It could be that staph has issues with neural viruses even when in the eczema.

eczema vaccinatim: staph with small pox vaccine
http://en.wikipedia.org/wiki/Eczema_vaccinatum

eczema herpeticum: staph with herpes simplex virus (chicken pox is herpes zoster)
http://en.wikipedia.org/wiki/Eczema_herpeticum
any connection to some forms of multiple sclerosis?

D68 and asthma staph
Is the eczema linked asthma associated with D68 paralysis the kind with staph infecting the skin? The D68 deaths are associated with staph infections but when they looked for an infection with the enterovirus they did not see staph???? (washington post article) Is that because it has become an autoimmune disease?

severe asthma and poliomyelitis...is this the mycobacteria asthma or staph asthma?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1438328/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1626728/
http://www.ncbi.nlm.nih.gov/pubmed/3508063
http://www.ncbi.nlm.nih.gov/pubmed/7625547
http://www.ncbi.nlm.nih.gov/pubmed/4447516

Hopkins syndrome like MS has been associated with mycobacteria

MS and poliomyelitis overlap.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397915/
http://www.ncbi.nlm.nih.gov/pubmed/10877154
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1846230/?page=1
does poliomyelitis appear with enteroviruses while ms with herpes zoster?

psoratic arthritis and poliomyelitis....not sure what this means if they are both triggered by mycobacteria
http://onlinelibrary.wiley.com/doi/10.1002/art.1780280616/abstract

I have already looked at both eczema and psoriasis as triggers in MS cross-targeting with herpes zoster. Psoriasis has been linked with mycobacterias. Eczema with staph.

For the people who had a reaction with the polio virus: did they have asthma or eczema ? one in 200 got paralysis and I am trying to see if it was also autoimmune. the post-polio reactions are definitely autoimmune which has me suspicious.

Polio virus vaccines have been linked with poliomyelitis
http://www.virology.ws/2014/10/08/oral-polio-vaccine-associated-paralysis-in-a-child-despite-previous-immunization-with-inactivated-virus/
" so-called vaccine-derived polioviruses (VDPV) can cause poliomyelitis " from oral vaccines only...this is new to me and I will comment when i have a better understanding of this.

Monday, April 13, 2015

19th century jumping frenchmen could have been suffering from an autoimmune disease

Maine lumberjack jumping disease
http://en.wikipedia.org/wiki/Jumping_Frenchmen_of_Maine
The startle reflex is located in the brain stem.

Could this have been an autoimmune disease of the brain stem?

Legionnaire outside and the Borna virus inside the brain stem cells?

Legionnaires disease is an issue in the Maine area.
http://www.pressherald.com/2011/11/29/legionnaires-disease-cases-jump-in-state-new-england_2011-11-29/

Legionnaire and neurological connections exist
http://www.ncbi.nlm.nih.gov/pubmed/15026520
http://www.ncbi.nlm.nih.gov/pubmed/22998348

Note that the startle reflex is in the brain stem where legionnaire can infect

Brain stem and legionnaire
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC491213/
http://www.ncbi.nlm.nih.gov/pubmed/2954126
http://www.ncbi.nlm.nih.gov/pubmed/16501905

borna virus typically thrives in the brain stem and infects both birds and mammals
http://www.ncbi.nlm.nih.gov/pubmed/7789150
but bird are said to be the "carriers"
http://www.2ndchance.info/MacawWastingSyndr-Berg2001.pdf

Roseola (6th disease) and the autoimmune diseases caused by cross-targeting

Those kids with 6th disease hhv6 also known as Roseola should not be given the DTP vaccine. Or those with c.tetanus infections should take care not to catch herpes viruses.

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease. The immune system is instructed to destroy both the inside and the outside of the target.

Autoimmune Heart disease caused by autoimmune cross-targeting

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease. The immune system is instructed to destroy both the inside and the outside of the target.

The Chagas parasite called t.cruzi can infect the heart muscle. If a virus infects the heart muscle at the same time an autoimmune reaction can be triggered.

Chagas and autoimmune heart disease
http://www.ncbi.nlm.nih.gov/pubmed/8650474
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC88915/
http://www.ncbi.nlm.nih.gov/pubmed/16323421
http://www.ncbi.nlm.nih.gov/pubmed/8878420

Viruses that infect the heart
http://circ.ahajournals.org/content/119/19/2615.full

When failed hearts are examined chagas and adenoviruses are common
http://www.ncbi.nlm.nih.gov/pubmed/25442238

new viruses of the heart...chikungunya?
http://www.sciencedirect.com/science/article/pii/0002870373904596
http://www.ncbi.nlm.nih.gov/pubmed/25626645

We can see a different example of autoimmune heart disease with strep infections. If strep triggers the immune system to target the heart at the same time as a virus infects the myocytes then autoimmune disease can result.

Rheumatic Fever autoimmune heart disease: cross-targeting of strep with coxsackie
http://www.ncbi.nlm.nih.gov/pubmed/25191648
http://www.ncbi.nlm.nih.gov/pubmed/18608177

Tuesday, April 7, 2015

T.gondii and Bee venom

Do people with bee sting allergies have t.gondii infections?

I have connected T.gondii with a variety of things: Seizures, Epilepsy, schizophrenia....but they are all autoimmune which means cross-targeting autoimmunity must be occurring. A virus has to trigger the attack at the target tissue from the inside. Are these autoimmune diseases all bee sensitive because of their connection to T.gondii?

Schizophrenia: t.gondii and the cytomegavirus
http://www.sciencedaily.com/releases/2013/03/130308111315.htm

Bee sting reactions have been found in schizophrenia patients
http://www.ncbi.nlm.nih.gov/pubmed/5239954

I have connected in the past seizures/epilepsy with t.gondii and enteroviruses
http://angelabiggs.blogspot.com/2015/01/nodding-disease-epilepsy-seizuresare.html

Seizures and bee stings
http://epilepsyfoundation.ning.com/group/support-for-cps/forum/topics/bee-stings-and-seizures?commentId=2217546%3AComment%3A908079&xg_source=activity&groupId=2217546%3AGroup%3A819391
http://www.ncbi.nlm.nih.gov/pubmed/22100477
http://www.japi.org/february_2012/11_cr_stroke_after_multiple.pdf

epilepsy and wasp stings
http://www.ncbi.nlm.nih.gov/pubmed/8844507
http://jnnp.bmj.com/content/74/1/134.2.full

Does Apis mellifera venom (honey bee venom) effect T.gondii?

I can't see this paper to find out:

Effect of Bee Venom on Toxoplasma gondii Tachyzoites in vitro - Ahmad G. Hegazi, Hassan A. El-Fadaly and Ashraf M. BARAKAT (Egypt)

T.gondii is carried by mice and cats
T.cruzi is carried by kissing bugs and the dogs that eat them

T.cruzi which causes changas is killed by honey bee venom
http://www.ncbi.nlm.nih.gov/pubmed/23562368

The Kissing bug carries the T.cruzi the way mice carry T.gondii
http://blog.mysanantonio.com/animals/2013/09/san-antonio-humane-society-says-chagas-disease-possible-in-local-dogs/
note that kissing bugs are nocturnal so keep your pet in at night

Hymenoptera are the venom group of Apoidea (bees), Vespoidea (wasps, hornets, and yellow jackets), and Formicidae (ants).

What is it in the bee sting that Toxoplasmas dislike? perhaps the compound apamin which can cross the blood brain barrier. (our nerves don't like it either)
http://pubs.acs.org/doi/abs/10.1021/bi00682a035

Interestingly HoneyBee venom has been a remedy for malaria too.

Panafrican News Agency (PANA). 17 September 1997. Yahya el Hassan. "Curing Malaria with Bee Stings in Sudan." [Internet]. [Accessed 24 Dec. 1998].

https://books.google.com/books?id=JlSJDj5Lt98C&pg=PA153&lpg=PA153&dq=bee+stings+and+malaria&source=bl&ots=kXRWjUnlba&sig=Q7s5Av9JLOys_nMEi8I5pfzmRUg&hl=en&sa=X&ei=oeQlVZaHA8K1oQTxpoHACQ&ved=0CCkQ6AEwAg#v=onepage&q=bee%20stings%20and%20malaria&f=false

Mycobacteria and shellfish shells allergy

Do people with mycobacterial infections have shellfish allergies?

defensin is an antimicrobial compound in shellfish shells
http://www.ncbi.nlm.nih.gov/pubmed/23000749

Defensins family compounds are the major defense of the immune system against mycobacteria
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242998/
http://www.ncbi.nlm.nih.gov/pubmed/24762307

Parkinson's and shellfish shell allergic reaction? crawdads were boiled with the shell on
http://forum.parkinson.org/index.php?/topic/17534-parkinsons-and-issues-with-shellfish/

Parkinson's has been associated with the mycobacteria called Nocardia
Parkinson's and psoriasis often pair up together too.
http://angelabiggs.blogspot.com/2014/10/cross-targeting-autoimmunity-in.html

Psoriasis has also been associated with mycobacteria

Has psoriasis been associated with shellfish allergy?

crohn's and psoriasis seem to be connected and might be the same disease
http://www.ncbi.nlm.nih.gov/pubmed/12789169

Note that eating shellfish is now said to help crohn's
http://www.emaxhealth.com/1020/crab-shrimp-and-lobster-could-offer-crohns-disease-help

are they killing the mycobacterias before allergy develops or is this just safer to have a kill-off go on in your intestine?

Friday, April 3, 2015

Central america's mystery chronic kidney disease could be autoimmune if malaria parasite cross-targets with adenovirus or Glyphosate

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while an infection marks the outside and the combination triggers autoimmune disease.

Malaria
Infects the kidney of Sugar cane workers at higher rates because the Plasmodium type of parasite grows on the sugar cane.

Chronic Kidney disease of Central America
http://www.npr.org/blogs/goatsandsoda/2015/02/04/383628551/new-clues-to-mysterious-kidney-disease-afflicting-sugar-cane-workers
http://investigations.nbcnews.com/_news/2012/10/16/13866856-mystery-kidney-disease-decimates-central-america-sugarcane-workers

Kenya, malaria and sugar cane
http://www.ncbi.nlm.nih.gov/pubmed/9754665

Sri Lanka battles malaria too
http://globalhealthsciences.ucsf.edu/sites/default/files/content/ghg/mei-eliminating-malaria-sri-lanka-lowres.pdf

Adenoviruses suspects in Central America
http://www.ncbi.nlm.nih.gov/pubmed/19903214
21% are subgroup B which can infect the kidney

The other option is Glyphosate which is a pesticide used in central America and in Sri Lanka.
http://www.ncbi.nlm.nih.gov/pubmed/25596925
http://www.publicintegrity.org/2014/03/13/14418/sri-lanka-bans-monsanto-herbicide-citing-potential-link-deadly-kidney-disease
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945589/
The pesticide would enter into kidney cells marking the inside as foreign instead of the virus. (not requiring any binding of metals to set the reaction off)

If the person has both infections at the same time or exposure to a pesticide that migrates into kidney cells cross-targeting autoimmunity can be triggered....or at least that is my hypothesis.

We already know that adenoviruses are a serious problem with Kidney transplants.
http://www.ncbi.nlm.nih.gov/pubmed/14533942
http://www.ncbi.nlm.nih.gov/pubmed/20946204

In a non immunocompromised patient adenoviruses may manifest differently.

Is chronic kidney disease an autoimmune disease?

Antibodies to EPO in chronic kidney disease
http://www.nature.com/ki/journal/v81/n8/full/ki2011500a.html

Anti-erythropoietin (EPO) antibodies help against malaria. EPO is made in the kidney
http://www.nature.com/icb/journal/v83/n6/full/icb200589a.html
http://iai.asm.org/content/early/2013/10/09/IAI.00929-13.full.pdf

Hypotheses: Autoimmune Cross-targeting, Co-carcinogenesis, and Quorum complications