Basophils are the liaisons for the TH2 cells.
Visible infections
Basophils produce the burst of il-4 that develops TH2
https://www.ncbi.nlm.nih.gov/pubmed/14764715
http://jem.rupress.org/content/200/4/507
Basophils are antigen presenting cells to the Th2 cells using the MHC2 containing proteins of parasites or bacteria found in the cytosol. Basophils can take MHC2 from mdendritic cells through trogocytosis. Trogocytosis is the transfer of plasma membrane.
https://www.ncbi.nlm.nih.gov/pubmed/28096423
Basophils are required for the Th2 immunity to Haptens
https://www.semanticscholar.org/paper/Basophils-are-required-for-the-induction-of-Th2-to-Otsuka-Nakajima/0f9d25d27b6bbc6f3c5299f3b2db78d80a61a51e
Haptens are the incomplete antigens or peptides of toxins or poisons.
Urushiol of poison ivy is oxidated in skin cells and the hapten duinon is released
Penicillin can also be oxidized to be a hepatin.
The majority of allergic contact dermatitis involves hepatins and Basophils.
GM-csf Vacuole bacteria
When exposed to GM-csf the Basophil's secrete il-6 and help make th17
https://www.nature.com/articles/srep41744
GM-csf exposed mDendritic make il-23 which triggers TH17 cells
GM-csf creates TH17 dependent on il-6
http://jem.rupress.org/content/205/10/2281
TH17 triggers with both il-6 and il-23 and cause the popping of vacuole bacteria (il-22)
il-3 Viral or cytosol parasites/bacteria like t.gondii or mycobacteria
il-3 increases the MHC2 on basophils and interactions between mDendritic cells occur.
These cytosol bacteria infections will be presented to TH2 when such MHC2 are handed over from mdendritic cells to Basophils.
Non enveloped viruses use lysis to exit cells using low oxygen and viral proteins do dissolve membrane while histamine from basophils and mast cells increase the oxygen in the area
Visible infections
Basophils produce the burst of il-4 that develops TH2
https://www.ncbi.nlm.nih.gov/pubmed/14764715
http://jem.rupress.org/content/200/4/507
Basophils are antigen presenting cells to the Th2 cells using the MHC2 containing proteins of parasites or bacteria found in the cytosol. Basophils can take MHC2 from mdendritic cells through trogocytosis. Trogocytosis is the transfer of plasma membrane.
https://www.ncbi.nlm.nih.gov/pubmed/28096423
Basophils are required for the Th2 immunity to Haptens
https://www.semanticscholar.org/paper/Basophils-are-required-for-the-induction-of-Th2-to-Otsuka-Nakajima/0f9d25d27b6bbc6f3c5299f3b2db78d80a61a51e
Haptens are the incomplete antigens or peptides of toxins or poisons.
Urushiol of poison ivy is oxidated in skin cells and the hapten duinon is released
Penicillin can also be oxidized to be a hepatin.
The majority of allergic contact dermatitis involves hepatins and Basophils.
GM-csf Vacuole bacteria
When exposed to GM-csf the Basophil's secrete il-6 and help make th17
https://www.nature.com/articles/srep41744
GM-csf exposed mDendritic make il-23 which triggers TH17 cells
GM-csf creates TH17 dependent on il-6
http://jem.rupress.org/content/205/10/2281
TH17 triggers with both il-6 and il-23 and cause the popping of vacuole bacteria (il-22)
il-3 Viral or cytosol parasites/bacteria like t.gondii or mycobacteria
il-3 increases the MHC2 on basophils and interactions between mDendritic cells occur.
These cytosol bacteria infections will be presented to TH2 when such MHC2 are handed over from mdendritic cells to Basophils.
Non enveloped viruses use lysis to exit cells using low oxygen and viral proteins do dissolve membrane while histamine from basophils and mast cells increase the oxygen in the area
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