TGF-B1 burst part of the CTL pathway (nuclear or mitochondrial viral infections)

TGF-B1 burst part of the CTL pathway (nuclear or mitochondrial viral infections)

cmv (a herpes virus) and epithelial cells secreted TGF-b1
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1001170

TGF-b1 release by platelets when exposed to herpes
https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2567.1997.00202.x

Platelets cause a TGF-b1 burst

il-4 and tgf-b1 induced Th9 differentiation from Th0
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090036/

IFNalpha from tlr9 of pDendritic cells in response to herpes simplex
http://www.pnas.org/content/101/31/11416

IFN alpha causes the correct MHC one to be expressed on the dendritic cells

IFN alpha raised il-21 levels from th9
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090036/

IFN alpha and il-21 receptor on T cells
https://www.ncbi.nlm.nih.gov/pubmed/15178704

TH9 and cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222918/

il-25 triggers il-9 release from th9
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982928/

platelets and CTL
https://www.ncbi.nlm.nih.gov/m/pubmed/18184798/

note that the Co-carcinogenesis hypotheses claims that most, not all but most cancers are a carcinogen with a nuclear virus.

TH9 secretes il-9 which inhibits tumor growth and il-21 which is involved with nuclear or mitochondrial viruses.

il-21 helps differentiate CTL and triggers TH17 ( TGF-B1 and il-21 together trigger TH17 to secrete il-26 (nuclear membrane popping) il-19 mitochondria popping and il-17F which calls CTL to the area.

CTL and platelets
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908083/

platelets and TGF-B1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271718/

TGF-B1 and CD8 differentiation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062738/

plasmacytoid dendritic secretes ifnalpha
https://www.ncbi.nlm.nih.gov/pubmed/11713464?dopt=Abstract

ifn alpha triggers proliferation of cd8
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212878/

ifn alpha induces B7
https://www.ncbi.nlm.nih.gov/pubmed/8752897

il-21 CD8 differentiates into CTL
https://www.ncbi.nlm.nih.gov/pubmed/23479229

follicular cd8
http://www.jimmunol.org/content/194/1_Supplement/71.9

th9 and CTL
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484462/

TH9 makes il-9 and il-21 (anti-tumor too)

https://www.ncbi.nlm.nih.gov/pubmed/28918288

CTL active in both cytosol or organelle viral infections

B7 activation or il-2 can trigger CTL
http://www.jimmunol.org/content/jimmunol/165/6/3088.full.pdf

il-2 induces fas ligand in CTL
https://www.ncbi.nlm.nih.gov/pubmed/9190908

note that B7 would be used with MHC1 which are mito or nuclear viruses while il-2 would be with TH1 infections of the cytosol...thus the CTL kills with FAS apoptosis