How does co- Carcinogenesis explain anti-depressants, blood thinners, and glioblastomas consuming themselves?

 Recently in the news cancer cells, specifically glioblastomas, were found to be self-destructive with anti-depressants and blood thinners.
http://www.sciencedaily.com/releases/2015/09/150924142514.htm

Francis Peyton Rous' Co-carcinogenesis hypothesis: that a virus and a carcinogen together cause cancer. (1966 nobel prize)

What I surmise from his hypothesis:

A virus enters a cell through a receptor, opens up and alters host DNA telomeres. The carcinogen with a benzene ring inhibits the virus' polymerase because viral polymerases have stronger binding affinities than the host's.


Glioblastomas have several virus culprits: hhv6, cmv, sv40, and jcv

HHV6 and CMV seem to use estrogen receptors to infect cells. (these might not be sensitive to the blood thinner treatment)

SV40 and JCV (simian virus and human polyoavirus) seem to use serotonin receptors.
These viruses are in the same family.

JCV and serotonin
http://www.ncbi.nlm.nih.gov/pubmed/19703243
serotonin inhibitors and block JCV infections

SV40 and serotonin
http://www.ncbi.nlm.nih.gov/pubmed/3022874
transgenic mice infected with sv40 have increased serotonin receptors

JCV, SV40 and BK virus are highly homologous viruses (related and similar)

Are these glioblastomas in the experiment sensitive to anti-depressants because started by JCV or SV40 use serotonin receptors?

serotonin receptors and anti-depressants (do they act like inhibitors ?)
http://www.ncbi.nlm.nih.gov/pubmed/21256009

What about the anti-depressants? The affect was a synergy between anti-depressants and blood thinners.

If telomeres have a central role in cancer is it possible blood thinners act on them?

Cycloastragenol was shown to stimulate telomere growth in 2009 (nobel prize)
http://www.luxivi.com/inform/7.html

Cycloastragenol was a chinese herb known to increase blood flow.

So the anti-depressants interfere with the virus at the receptor while the blood thinners are interfering with the viral telomere binding proteins?

When this came out I had mentally lumped ginko and cinnamon with it. Cinnamon and ginko both had life extentending properties and some suggested they had cancer protective abilities.  Why know one could pin point.  Both cinnamon and gingko seemed to be blood thinners too.

Gingko and rat's lifespan
http://www.ergo-log.com/ginkgolifespan.html

Cinnamon and worm's lifespan
http://www.life-enhancement.com/magazine/article/2285-cinnamon-extends-lifespan

Gingko is currently being examined for telomere lengthening
http://www.ncbi.nlm.nih.gov/pubmed/17312453

This might even be visable in the Gingko tree itself
http://www.ncbi.nlm.nih.gov/pubmed/20842436

Can medical blood thinners be acting on telomeres too?
Can simple cinnamon be lengthening telomeres?

What needs to be tested out:

Do other types of cancers with different virus triggers and different receptors fit this pattern? Can you put blood thinners with estrogen receptors inhibitors with  breast cancer cells and see the same self destruction of cancer? Is it a matter of selecting the right receptor?  At the same time? why do the drugs act together?

 Does cinnamon have an effect on telomeres? Can cinnamon replace the blood thinners in these experiments?

Brain Cancers and the Co-Carcinogenesis hypothesis

Francis Peyton Rous' Co-carcinogenesis hypothesis: that a virus and a carcinogen together cause cancer.

CMV (HHV5) and glioblastoma multiforme infection of glial cells
http://www.med.wisc.edu/news-events/new-evidence-links-virus-to-brain-cancer/32922
http://www.ncbi.nlm.nih.gov/pubmed/25699229

Craniopharyngioma and the herpes virus simplex (HHV2) infection of pituitary gland
http://www.ncbi.nlm.nih.gov/pubmed/18976107
http://www.ncbi.nlm.nih.gov/pubmed/8906037

Head and neck cancers and Epstein-barr virus (HHV 4) infection of squamous cells
http://www.infectagentscancer.com/content/pdf/1750-9378-8-7.pdf

The estrogen receptor of nerves cycles to the mitochondria but the estrogen receptors of adrenal cells like squamous cells cycle to the nucleus. Thus in nerves herpes breaks the mitochondria power house while in adrenal cells it destroys the nuclear cookbook.

Alzheimer's is herpes simplex (HHV1) infecting of the mitochondria of nerves thus destroying the nerves.
http://journal.frontiersin.org/article/10.3389/fnagi.2014.00202/full

Note that the virus alone does not cause cancer and that it needs a carcinogen. Co-carcinogenesis says both are needed.

 Imagine a virus as initially causing the DNA to replicate forever for it's own benefit.  Now imagine benzene which binds polymerases haulting copies.  Viruses have their own polymerases. Now imagine the carcinogen binds the viral polymerases better than the hosts.  So you have the cookbook of DNA open and no viral polymerase to compete with.

So what carcinogen gets into our brain? 

Co-carcinogenesis and lymphoma

Francis Peyton Rous' Co-carcinogenesis hypothesis: that a virus and a carcinogen together cause cancer.

Hodgkin lymphoma and multiple myeloma  and hepatitis B
http://www.ncbi.nlm.nih.gov/pubmed/26394533
http://www.ncbi.nlm.nih.gov/pubmed/23926082
http://www.ncbi.nlm.nih.gov/pubmed/26356141

Hodgkin's lymphoma and smoking
http://www.ncbi.nlm.nih.gov/pubmed/17684129

Liver cancer (hepatocellular carcinoma) and hepatitis C
http://www.ncbi.nlm.nih.gov/pubmed/26380652
http://www.ncbi.nlm.nih.gov/pubmed/9758109

Liver cancer, hepatitis C and smoking carcinogens
http://www.ncbi.nlm.nih.gov/pubmed/20447919


Burkitt's lymphoma and Flaviviruses (which use melanocortin receptors?)
http://www.ncbi.nlm.nih.gov/pubmed/11198662

Non hodgkin's lymphoma and mothball benzene risk
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1247554/

Is there an increased risk association between melanoma, prostate cancer, and Burkitt's lymphoma? Assuming the same virus triggers them all.

epstein barr virus and Burkitt's lymphoma
http://www.ncbi.nlm.nih.gov/pubmed/26325594

Does this epstein barr group have an increased risk of breast cancer?

Pituitary cancer and co-carcinogenesis

Francis Peyton Rous' Co-carcinogenesis hypothesis: that a virus and a carcinogen together cause cancer.

pituitary cancer: 2 types

D2 receptors and pituitary cancer microadenomas : are these flu triggered?
http://www.ncbi.nlm.nih.gov/pubmed/15126577
http://www.ncbi.nlm.nih.gov/pubmed/1352243

Estrogen receptors and pituitary cancer : macroadenomas large : are these herpes triggered?
http://www.ncbi.nlm.nih.gov/pubmed/20683030

Herpes virus and pituitary cancer risk
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917040/

so does herpes virus cause the macro while the flu causes the micro?

The carcinogen associated with pituitary tumors are nitrates.

Blood pressure medications has been associated with macroadenomas already.

cluster headache, nitrates, and pituitary macroadenoma   
http://www.drgaila.com/cluster-headache-caused-by-nitrates

this drug is used to lower blood pressure (vasodilator)

Co-carcinogenesis hypothesis and prostate cancer

Francis Peyton Rous' Co-carcinogenesis hypothesis: that a virus and a carcinogen together cause cancer.

Prostate cancer and flaviviruses? Previous post looked at flaviviruses, melanocortin receptors, and melanoma.

prostate and chikungunya virus
http://www.ncbi.nlm.nih.gov/pubmed/26167328

melanocortin receptors and prostate cancer
http://www.ncbi.nlm.nih.gov/pubmed/22842514

West nile case where his prostate was involved
http://www.star-telegram.com/living/family/moms/article3832474.html

Prostate cancer and melanoma
http://healthcare.utah.edu/healthlibrary/related/doc.php?type=88&id=p10776
http://www.medscape.com/viewarticle/813922
http://www.mdpi.com/2072-6694/7/2/670

melamona post
http://angelabiggs.blogspot.com/2015/09/skin-cancer-melanoma-and-melanocortin.html

Note that other viruses can cause cancer too: the key to the co-carcinogenesis hypothesis is that a virus and a carcinogen have to be together in the tissue.

Herpes virus and prostate cancer
http://www.practiceupdate.com/content/genital-herpes-may-double-prostate-cancer-risk/13075

Estrogen receptors and prostate cancer (assuming herpes uses estrogen)
http://onlinelibrary.wiley.com/doi/10.1002/pros.10242/abstract

Are there 2 forms of prostate cancer? can we tell them apart?

Benzene uses estrogen receptors so it could be the carcinogen
http://angelabiggs.blogspot.com/2016/06/benzene-carcinogen-binds-estrogen.html

Hypothesis Co-carcinogenesis: a virus and a carcinogen together cause cancer.

Francis Peyton Rous
Proved that viruses, specifically the HPV, were involved in tumors and that they could become cancer in 1911
He received the  nobel in 1966
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647430/

Co-carcinogenesis
This Cancer potentiation hypothesis was called Co-carcinogenesis
http://www.nature.com/onc/journal/v23/n38/full/1207822a.html

Herpes virus simplex 2 and Benzene together transformed regular cells into cancer 1982 paper

http://www.ncbi.nlm.nih.gov/pubmed/6293737

What is the Current support?

Viruses stabilize the telomeres and allow for unlimited copies
http://www.cell.com/cell-reports/pdf/S2211-1247(14)00973-5.pdf

Benzene blocks polymerases
http://www.ncbi.nlm.nih.gov/pubmed/2926830

Viruses have their own polymerases. Are the wrong polymerases inhibited thus releasing our own into unlimited copies?

Can we match cancers and viruses up?

Carcinogens, benzenes, cancer and polymerases

Hypothesis Co-carcinogenesis: a virus and a carcinogen together cause cancer.

Benzene may inhibit DNA synthesis through polymerases
http://www.ncbi.nlm.nih.gov/pubmed/2926830

Viruses have their own polymerases. Viruses open up the DNA cookbook and bind up the telomeres for unlimited copies. Does this prime the cells for a carcinogen? We should bring back the co-carcinogenesis theory of the 1980s where a virus and a carcinogen together causing cancer.

How many of these carcinogens will function like Benzene?

cig smoke: Benzoapyrene
https://en.wikipedia.org/wiki/Benzo(a)pyrene

Benzene aromatic, hydrocarbon from crud oil
https://en.wikipedia.org/wiki/Benzene

??? oxybenzone ??? the main ingredient in sunscreen is not?
https://en.wikipedia.org/wiki/Oxybenzone

Aflatoxin (peanut mold's toxin is aflatoxin)
https://en.wikipedia.org/wiki/Aflatoxin

Aflatoxin vs Benzene
http://chemistry.stackexchange.com/questions/4168/aflatoxin-versus-benzene-permissible-levels

equilenin
https://en.wikipedia.org/wiki/Equilenin

equilenin and cancer
http://www.ncbi.nlm.nih.gov/pubmed/25611945

doesn't quite look like estrogen because it has another benzene ring

Estrogen
https://en.wikipedia.org/wiki/Estrogen

benzene,Toulene, and zylene
http://www.ncbi.nlm.nih.gov/pubmed/9651624

Phenol groups and polymerases
http://www.ncbi.nlm.nih.gov/pubmed/12459026

Phenols are disinfectants. How are they killing bacteria? Are phenol based disinfectants stop DNA synthesis? (they are benzene rings with an OH group on them)

phenols and coal tar...Carbolic soap
https://en.wikipedia.org/wiki/Carbolic_soap

Phenols in carmex and chloraseptic spray

Phenols and alcohols are considered organic solvents one can use to stop PCR. Which means inhibiting polymeases.

Pentachlorophenol which is a chemical they use to treat outdoor wood with: fence posts, utility poles and railroad ties.  Also called pcp or angel dust.  Widely used as a fungicide in Chile.

Coal tar is on the carcinogen list.

Oxybenzone was looked at as a possible estrogen substance but as a great sunscreen agent it is in 90% of sunscreens and they claim not carcinogenic.

equilenin causes cancer, benzene causes cancer, coal tar phenols might cause cancer....but oxybenzone which is in our sunscreens doesn't cause cancer?

oh that's right they fed oxybenzone to rats and in such high quantities that people don't believe it causes cancer now.  What if oxybenzone only does if a virus is there? where it could inhibit the wrong polymerase

Note I haven't stopped using sunscreen. I live outdoors.  I know that sunburns can cause cancer but maybe they should check at least in a petri dish oxybenzone and westnile like viruses. They should look at removed melanomas for these flaviviruses ( not the HPV which is in the non-melamona type skin cancer). Maybe what we need is mosquito repelling stuff with the sunscreen.

most melanoma skin cancer is still probably triggered by the sun
http://www.ncbi.nlm.nih.gov/pubmed/76759/

Note that UV can release nitrite stores in the skin
http://www.nature.com/jid/journal/v134/n7/full/jid201427a.html
http://www.ncbi.nlm.nih.gov/pubmed/16544952

Patterns found concerning breast cancer while looking for autoimmune patterns:support for the Cancer Potentiation hypothesis called Co-carcinogenesis

Although this is an autoimmune blog I have noticed a few patterns concerning cancer and I have a few thoughts.

As I was pairing receptors up with the viruses that might be using them I noticed that cancers had receptor patterns.   Breast cancer has an"estrogen receptor" increased type.  I began to wonder if the virus involved in causing the cancer left it's mark in the form of expressed receptors. Could this form be connected to a herpes virus which I had connected to the estrogen receptor?  A breast cancer started by a type of herpes would express an increased number of estrogen receptors?

Herpes and estrogen receptors
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798450/

In nerves estrogen receptors cycle to the mitochondria which would explain how herpes hides there
http://www.pnas.org/content/101/12/4130.full.pdf

Ten percent of breast cancer metastasized to the bone. An area that herpes does not move to but that other viruses can....like HPV? Does the virus have an involvement with the metastasizing ?

HPV bone marrow
http://link.springer.com/article/10.1007%2FBF02257961#page-1

Viruses and breast cancer: epstein barr and HPV

http://www.ncbi.nlm.nih.gov/pubmed/17661684

HPV and breast cancer

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737128/

cannabinoids and breast cancer
http://www.ncbi.nlm.nih.gov/pubmed/19887554
http://naturalsociety.com/marijuana-kills-cancer-cells-admits-the-u-s-national-cancer-institute/

Breast cancer can metastasize to the CNS  (which is where the herpes virus family infects )
http://www.ncbi.nlm.nih.gov/pubmed/17661684 

Does the metastasizing patterns of cancers match the viral infection patterns?

One can have a virus that can trigger cancer and not develop the cancer. One can be exposed to a carcinogen and not develop can cancer. Hypothesis for cancer: is it the combination of a carcinogen and a virus that triggers cancer?

Herpes virus simplex 2 and Benzene together transformed regular cells into cancer 1982 paper

http://www.ncbi.nlm.nih.gov/pubmed/6293737

This Cancer potentiation hypothesis was called Co-carcinogenesis
http://www.nature.com/onc/journal/v23/n38/full/1207822a.html

Which carcinogens pair up with breast cancer ? obviously smoking could trigger it but can any carcinogen could push a virus infected cell into the oncogenic state?

HPV and cervical cancer has which receptor increased? Cannabinoid?
HPV infects the lung, the breast....can we see metastasizing patterns? there should be a higher rate of coexisting breast and cervical cancer if HPV is involved.



Looking at pancreatic cancer which is infected by the flu virus and coxsackie. Do we see the same pattern?

coxsackie and pancreatic cancer
http://www.ncbi.nlm.nih.gov/pubmed/1193416

Nicotine receptors increases with pancreatic cancer is this caused by the coxsackie virus?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832917/

Are D2 dopamine receptors are increased in pancreatic tumors by the flu virus?
http://press.endocrine.org/doi/full/10.1210/jc.2003-031039
http://www.ncbi.nlm.nih.gov/pubmed/11174837?dopt=Abstract

Benzene and pancreatic cancer
http://www.ncbi.nlm.nih.gov/pubmed/26293241

How does Benzene amplify the effect of a virus to become carcinogenic?
Benzene inhibits the polymerase?
http://www.ncbi.nlm.nih.gov/pubmed/2926830

 Benzene inhibits replication while viruses turn on replication. Benzene inhibits polymerases but viruses supply their own polymerases. Has the benzene inhibited the viral polymerase?

viruses are now being found to alter the telomeres, the ends of chromosomes, which typically limit the number of times of division.
http://www.cell.com/cell-reports/pdf/S2211-1247(14)00973-5.pdf

So is it unlimited replication set up by the virus in the host cell but now the viral polymerases are inhibited by benzene which leaves our cells functioning but out of control?

HPV Human Papillomavirus, cannabinoid receptors, and the triggering of autoimmune cross-targeting

First HPV and Cancer (below HPV and autoimmunity)

Francis Peyton Rous' Co-carcinogenesis hypothesis: that a virus and a carcinogen together cause cancer.

There exists a long list of cancers associated with HPV: and interestingly a strong link with cannabinoid receptors exists. Does HPV use these receptors?

Angiogenesis, the cervical cancer and HPV
http://www.ncbi.nlm.nih.gov/pubmed/10220796

epithelial and HPV
http://www.ncbi.nlm.nih.gov/pubmed/15187189

inhibition of skin cancer by cannabinoid receptors
http://www.ncbi.nlm.nih.gov/pubmed/12511587

HPV and non melanoma skin cancer: cutaneous squamous cell carcinoma
http://www.ncbi.nlm.nih.gov/pubmed/15782686
http://www.ncbi.nlm.nih.gov/pubmed/26351427
http://www.ncbi.nlm.nih.gov/pubmed/16537712
http://www.ncbi.nlm.nih.gov/pubmed/14675206
http://www.ncbi.nlm.nih.gov/pubmed/16303684

HPV 16 with squamous and HPV 18 with adenocarcinoma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361088/

HPV and non melanoma skin cancer: Basal cell carcinoma
http://www.nature.com/jid/journal/v115/n1/abs/5600757a.html

There are 2 major types of non melanoma skin cancer: basal and squamous

Basal has been linked to HPV18
http://jvi.asm.org/content/70/1/10.abstract

Squamous skin carcinoma and HPV16
https://www.ncbi.nlm.nih.gov/pubmed/1330760

Oral squamous has been connected to HPV16
http://www.cancertherapyadvisor.com/head-and-neck-cancer/oropharyngeal-squamous-carcinoma-hpv16-higher-risk-patient-treatment/article/469170/

since the oral and tonsil regions are high in CBR2 it looks like HPV16 uses CBR2 creating squamous cells and HPV18 uses CBR1 creating adenocarcinomas.  (but this needs to be proven)

Alpha verse Beta HPV types
alpha cervical
beta skin
http://www.ncbi.nlm.nih.gov/pubmed/25131163

CBR2 and immune system cells
https://www.ncbi.nlm.nih.gov/pubmed/9808554

hpv16 and immune cells? the immune system has a lot of CBR2

cannabinoid receptors are upregulated in skin cancer
http://www.ncbi.nlm.nih.gov/pubmed/23601830
http://www.ncbi.nlm.nih.gov/pubmed/23361273
http://www.ncbi.nlm.nih.gov/pubmed/20335147

angiogenesis inhibited by cannabinoid receptors
http://www.ncbi.nlm.nih.gov/pubmed/12514108

Cannabis oil and skin cancer treatment?
http://www.cbdfarm.org/about/testimonials/testimonial-dana-california.html

HPV cells and Cannabinoid
http://www.ncbi.nlm.nih.gov/pubmed/18296861

colon cancer and HPV
http://www.ncbi.nlm.nih.gov/pubmed/23895733

breast cancer and HPV
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737128/

cannabiniod receptors and breast cancer cells
http://www.ncbi.nlm.nih.gov/pubmed/19887554

lung cancer and HPV
http://www.ncbi.nlm.nih.gov/pubmed/23571474

hypothalamus and cannabinoid receptors: energy level
http://www.ncbi.nlm.nih.gov/pubmed/22778221

I can't connect HPV directly to the cannabinoid receptors. All of this could be wrong but for now it is an idea or starting place.

Autoimmune disease and HPV 

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease.  The immune system is instructed to destroy both the inside and the outside of the target.

(pots was removed because it might not be an autoimmune disease rather...a reovirus infection)

HPV and autoimmunity of the hypothalamus causing seizures?

HPV in the brain and seizures
http://www.miriamgrossmanmd.com/say-its-not-so-hpv-in-the-brain/

if the kids had HPV from their mothers then got the pertussis vaccine they could have the inside and the outside of the hypothalamus cross-targeted
http://www.cdc.gov/vaccinesafety/concerns/febrile-seizures.html

the hypothalamus has cannabinoid receptors
http://www.ncbi.nlm.nih.gov/pubmed/9714422

Multiple sclerosis and HPV

Cannabinoid receptors on skin and sensory nerves
http://www.ncbi.nlm.nih.gov/pubmed/15927811

Case reports have suggested the development of MS after vaccination but studies of the vaccine in general have not found an increase risk. Why is that ?

Probably because only those who have a  mycobacteria infection would have the risk of the outside of the nerves already being infected.

newer post: http://angelabiggs.blogspot.com/2016/05/multiple-sclerosis-and-autoimmune-cross.html

What are the treatment options?

Warts treated with cannabis oil
https://www.facebook.com/notes/franco-loja/cannabis-cures-warts/10150261601546923

cannabinus and HPV
http://www.ncbi.nlm.nih.gov/pubmed/1660417

HPV and shiitake mushrooms
http://www.healthline.com/health-news/mushroom-extract-cures-hpv-infections-110614

shiitake mushrooms and cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339609/


shiitake mushrooms and AHCC...is this extract acting on the accelerated growth?

Posted on February 28, 2007 by Dr. Gary Pack

Activated hexose correlated compound (AHCC) is a mixture of polysaccharides, amino acids, lipids and minerals which come from Basidiomycete mushrooms. Twenty percent of AHCC is composed of alpha-1,4-glucans. AHCC has been shown to change immune function, fight infections, increase liver detoxification enzymes and act as an antioxidant. It increases natural killer (NK) cells in cancer […]