Autoimmune cross-targeting hypothesis summary

http://angelabiggs.blogspot.com/2015/03/autoimmune-trigger-hypothesis.html

Avian flu and the dopamine receptor

Viruses use receptors to gain access to host cells. Looking at the autoimmune diseases triggered by the avian flu: parkinson's, diabetes, autism of the frontal lobe I realized that they were all dopamine organs.

The dopamine 2 receptor is on the pancreas
http://www.jbc.org/content/280/44/36824.full

D2 and the substantia nigra
http://www.ncbi.nlm.nih.gov/pubmed/1825842
http://www.hindawi.com/journals/ijmc/2011/403039/

Frontal lobe and D2
http://www.sciencedirect.com/science/article/pii/S1053811906011049

The flu virus and parkinson's
http://news.sciencemag.org/brain-behavior/2009/08/bird-flu-virus-possible-trigger-parkinsons

Could it be that the flu uses the D2 receptor to infect cells?

The receptor that people have found them using is hemaggluten. Hemaggluten is the antigen on red blood cells that we use to identify blood types.  This had me puzzled.

However the dopamine D2 receptors have a hemogglutin epitope. ( a matching piece)
http://www.jbc.org/content/274/28/19894.abstract

If we know which organs viruses can infect we can predict which autoimmune diseases they can trigger.

Autoimmune hypothesis : autoimmunity is triggered by overlapping infections cross-targeting immune attack.  A virus infects the inside while a larger infection marks the outside.

Interesting extras:

humans and birds use of dopamine to create vocalizations
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362661/

Eggs may have a protein that inhibits bird flu virus
http://www.sciencedaily.com/releases/2015/05/150508082629.htm

Note that swine flu might use the similar receptors because it also found in the pancreas
http://www.ima.org.il/FilesUpload/IMAJ/0/40/20206.pdf

Narcolepsy and d2
https://books.google.com/books?id=yTLkszI1to0C&pg=PA65&lpg=PA65&dq=hypothalamus+dopamine+d2+narcolepsy&source=bl&ots=HxMs7elGV8&sig=6AkV7PFe4f1iZGo_pLSel8qLz_8&hl=en&sa=X&ei=5G-FVYX2KcadygTOjp24Dg&ved=0CC0Q6AEwAw#v=onepage&q=hypothalamus%20dopamine%20d2%20narcolepsy&f=false

Swine flu vaccine and narcolepsy...swine flu is also found in the brain in dopamine organs
http://www.newscientist.com/article/dn24772-flu-vaccine-helps-unravel-complex-causes-of-narcolepsy.html#.VYVw0GK9KK0

Flu then narcolepsy
http://www.ncbi.nlm.nih.gov/pubmed/11421428

Is narcolepsy cross-targeting autoimmunity? Did these kids have another infection?

Strep and narcolepsy has been suspected
http://www.aasmnet.org/jcsm/ViewAbstract.aspx?pid=28864

Target in narcolepsy: hypocretin neurons?
http://healthysleep.med.harvard.edu/narcolepsy/what-is-narcolepsy/science-of-narcolepsy

Gluten ataxia, the cerebellum, and campylobacteria from cross-targeting autoimmunity

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease.  The immune system is instructed to destroy both the inside and the outside of the target at the same time.

Ataxias and the cerebellum is this a form of autoimmunity?
http://www.ncbi.nlm.nih.gov/pubmed/25823827
http://www.ncbi.nlm.nih.gov/pubmed/21827889

Campylobacteria is a suspect for triggering autoimmune Guillian barre
http://www.ncbi.nlm.nih.gov/pubmed/26017721

Guillain barre has also been linked to epstein barr (mono virus)
http://www.ncbi.nlm.nih.gov/pubmed/230116
Guillain barre has also been connected to enteroviruses like polio
http://www.ncbi.nlm.nih.gov/pubmed/17867475

Guillain barre is the most common peripheral neuropathy with symptoms of pain starting at the feet and moving up
http://www.merckmanuals.com/professional/neurologic-disorders/peripheral-nervous-system-and-motor-unit-disorders/guillain-barr-syndrome-gbs


Campylobacteria, sutterella and the cerebellum
http://www.ncbi.nlm.nih.gov/pubmed/19200732
http://www.ncbi.nlm.nih.gov/pubmed/15778812
there bacteria generate antibodies against or infect the cerebellum

Epstein barr (mono) infects the cerebellum (marks the inside trigger autoimmunity )
http://www.ncbi.nlm.nih.gov/pubmed/8380845

Sutterella is a close relative of campylobacteria and may cause similar issues.

Sutterella has been linked to autism of the cerebellum
http://www.ncbi.nlm.nih.gov/pubmed/24188502

Purkinje antibodies and autism
http://www.ncbi.nlm.nih.gov/pubmed/18514431

In the United Kingdom store bought chicken often contains campylobacteria
http://www.independent.co.uk/news/uk/home-news/majority-of-supermarket-chickens-contaminated-with-campylobacter-food-bug-10072763.html
This could account for the ataxia in the area.

Gluten Ataxias and purkinje fibers
http://www.ncbi.nlm.nih.gov/pubmed/21294863

Measles virus infects the cerebellum
http://jama.jamanetwork.com/article.aspx?articleid=663021,
(would the dead vaccine version bring antibodies to the cerebellum because the pieces still bind?)

1/3 of gluten ataxias have celiac &/or DH which indicates that e.coli migrates to the cerebellum too but i need to find a refence for this
http://www.hindawi.com/journals/nri/2012/102153/
http://www.ncbi.nlm.nih.gov/pubmed/23478323

Urinary tract infections and cerebral palsy....e.coli
http://downloads.hindawi.com/journals/ijn/2013/937268.pdf

Note that this blog has indicated that there are different kinds of autism with autoimmunity focused on different areas of the brain. The cerebellum is only one kind.
http://angelabiggs.blogspot.com/2015/04/6th-disease-and-autoimmune-disease.html
http://angelabiggs.blogspot.com/2015/02/maternal-antibodies-causes-one-form-of.html
http://angelabiggs.blogspot.com/2015/02/mmr-vaccine-overlapping-with-sutterella.html