Nodding disease, epilepsy, seizures....are they from autoimmune cross-targeting? a parasite with an enterovirus?

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while an infection marks the outside and the combination triggers autoimmune disease.

If we say these diseases are autoimmune can we find the 2 infections for each:

nodding disease: Trypanosoma brucei and polio or live polio vaccine (an enterovirus)

epilepsy: t.gondii or t.cruzi or malaria and enteroviruses

RA seizures: polio/enterovirus and  mycoplasmas?

Description of nodding disease
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646179/

Trypanosoma brucei a parasite of the black fly infects kids with the african nodding disease
http://workforce.calu.edu/Buckelew/Trypanosoma%20brucei%20rhodesiense%20brain%20section.htm   or is it the worm O.volvulus?

 trypanosome in the nervous system with spinal lesions
http://www.veterinaryresearch.org/content/42/1/63

The trypanosoma parasite can also effect the hypothalamus
http://www.ncbi.nlm.nih.gov/pubmed/15304634

Onchocerca volvulus and epilepsy ? is this the mild form of cross-targeting with an enterovirus whereas the trypanosome causes the nodding disease?
http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0002147

Polio, live polio vaccines and the African nodding disease? Are they causing cross-targeting triggering the nodding disease ? Is nodding disease autoimmune?  Enteroviruses infect and replicate in the hypothalamus.

Can we look for similar patterns with the parasite t.gondii?

schizophrenia and the hypothalamus
http://www.ncbi.nlm.nih.gov/pubmed/20923924

Schizophrenia and epilepsy
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768382/

T.Gondi and epilepsy
http://www.ncbi.nlm.nih.gov/pubmed/2479399

Cats with t.gondi and seizures
http://www.ncbi.nlm.nih.gov/pubmed/15914056

schizophrenia and febrile seizures
http://www.ncbi.nlm.nih.gov/pubmed/15653280

toxocariasis and epilepsy
http://www.ncbi.nlm.nih.gov/pubmed/22905274

Autoimmune epilepsy and anti-nmda receptor
http://www.annalsofian.org/article.asp?issn=0972-2327;year=2013;volume=16;issue=4;spage=577;epage=584;aulast=Pandit

anti-nmda receptor antibodies in pediatric epilepsy
http://www.ncbi.nlm.nih.gov/pubmed/25625089
http://www.ncbi.nlm.nih.gov/pubmed/24656207

They can't find the parasite in the babies. Perhaps the mother was the infected one? Here we do have a direct connection to enteroviruses.

Schizophernia and NMDA
http://www.ncbi.nlm.nih.gov/pubmed/25069261

T.cruzi (chagas) and seizures
http://www.ncbi.nlm.nih.gov/pubmed/6789802
http://www.ncbi.nlm.nih.gov/pubmed/19859889

malaria and seizures...and enteroviruses
http://www.ncbi.nlm.nih.gov/pubmed/8761576
http://www.ncbi.nlm.nih.gov/pubmed/15117128
http://www.ncbi.nlm.nih.gov/pubmed/?term=malaria+seizures+enterovirus
http://www.ncbi.nlm.nih.gov/pubmed/25423900

What I am thinking: around 20% of the population has t.gondii but 20% do not have schizophrenia and 20% of babies do not have seizures so autoimmune cross-targeting might be occurring to set things off.  In the case of seizures...an enterovirus.

Absent seizure with MG and lupus in a child
(mycoplasmas with polio/enterovirus)
http://www.ncbi.nlm.nih.gov/pubmed/9294315
http://www.ncbi.nlm.nih.gov/pubmed/4999164
http://www.ncbi.nlm.nih.gov/pubmed/5483199
http://www.ncbi.nlm.nih.gov/pubmed/5433055

Rheumatoid arthritis, mycoplasmas, and seizures
http://www.ncbi.nlm.nih.gov/pubmed/17690887
http://www.ncbi.nlm.nih.gov/pubmed/19049505
http://www.ncbi.nlm.nih.gov/pubmed/15066670 (anti cardio lipin)
cardiolipin antibodies and RA
http://www.ncbi.nlm.nih.gov/pubmed/3664159

Is Myasthenia gravis an autoimmune disease caused by the cross-targeting of mycoplasmas and a virus that infects the thymus?? are there more cases of MG after D68 ?

Autoimmune cross-targeting hypothesis: that the layering of 2 infections on one target confuses the immune system into autoimmune attack. A virus marking the inside of the thymus and an infection like mycoplasmas marking the outside for myasthenia gravis

polio virus and thymus
http://www.ncbi.nlm.nih.gov/pubmed/20368632

the d68 is a similar enterovirus...does it infect the thymus?

They were looking at enteroviruses as a diabetes trigger with a thymus connection for a while.
http://brainimmune.tumblr.com/post/65440027379/an-enterovirus-attacking-the-thymus-may-play-a-key but i believe only coxsackie has been connected.  I think it is the only enterovirus that infects the pancreas

this MG looked like the post-polio syndrome...but was it a real overlap by the virus?
http://www.ncbi.nlm.nih.gov/pubmed/16546772

epstein-barr and thymus???
http://www.ncbi.nlm.nih.gov/pubmed/20517934


Mycoplasmas and viruses in MG???
http://www.ncbi.nlm.nih.gov/pubmed/689042
they didn't see any

Families will have MG and/or RA
http://archinte.jamanetwork.com/article.aspx?articleid=576834


Extra stuff: 
What is rippling muscle disease? Here it is seen overlapping MG
http://www.ncbi.nlm.nih.gov/pubmed/25534474

acquired rippling muscle disease is autoimmune
http://www.ncbi.nlm.nih.gov/pubmed/21295981
http://www.ncbi.nlm.nih.gov/pubmed/8639072

antibodies in rippling muscle..any clues to a virus? the antibodies are to muscles
http://www.ncbi.nlm.nih.gov/pubmed/10529381

Here are some enteroviruses in muscle biopsies
http://ard.bmj.com/content/49/5/310.short

not the enterovirus we are looking at but related
http://www.pnas.org/content/89/1/314.short

High number of MG have antibodies against muscles
http://www.ncbi.nlm.nih.gov/pubmed/22882218

Is this paralysis from the D68 enterovirus due to autoimmune cross-targeting? do the paralyzed kids without asthma have eczema?

A large number of the children who developed paralysis from the D68 entrovirus had asthma. Did the ones who didn't have asthma have eczema?
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6336a4.htm?s_cid=mm6336a4_w

the D68 virus was not found in the spinal region but are antibodies to the virus there? Is an autoimmune reaction causing the paralysis?
http://www.healthline.com/health-news/enterovirus-d68-likely-to-blame-paralysis-100114#1

note that a ten your old girl who died had a staph sepsis infection
http://www.providencejournal.com/news/health/20141001-update-10-year-cumberland-girl-who-died-of-sepsis-carried-enterovirus-tips-video.ece

The virus has not been found in spinal fluid and they are now looking for antibodies to the d68 virus. Other bacterial infections have not been found in the spinal fluid either.

Later a little 4 year old boy went to bed with pink eye and then woke up and died from d68...pink eye can be caused by staph
/http://news.health.com/2014/10/06/officials-report-first-confirmed-child-death-due-to-enterovirus-d68
http://www.cdc.gov/conjunctivitis/clinical.html

Rhode island child dies with a staph sepsis infection on top of the d68 virus
http://www.foxnews.com/health/2014/10/01/rhode-island-child-dies-after-contracting-enterovirus-68-other-infection/

We have seen an overlap of eczema and a different entrovirus in the past:

eczema which I think is staph and the entrovirus called coxsackie
http://www.ncbi.nlm.nih.gov/pubmed/23776120
http://www.pediatricsconsultant360.com/article/22-month-old-child-atypical-enteroviral-exanthem

Donald Leung of national jewish has isolated staph from eczema but there which came first seems to be disputable.  staph makes a pigment with egg and milk which seems to correlate with the sensitivity of eczema to those allergens.  Highly suspicious to me.

Could a similar overlap be occurring with D68?
Could the paralysis be an autoimmune reaction from cross-targeting of these infections on the nervous system?

Autoimmune cross-targeting hypothesis: that the layering of 2 infections on one target confuses the immune system into autoimmune attack.  A viral infection marks the inside and something marks the outside of the nerves like the staph.

Note that on previous posts I had MS associated with the chickenpox virus which travels in nerves with mycobacterias or staph....  either one marking the outside of the nerves. Different autoimmune diseases because of the difference in viruses??????  Is this paralysis from D68 autoimmune?

the MRI of several children showed gray matter inflammation along the spinal cord which could be a bacterial or is it the d68 infection????...staph?????  

spinal infection and staph
http://www.wjes.org/content/4/1/31

Extra notes:  Polio which is a similar enterovirus does not cause paralysis in every person infected. In fact most people do not develop paralysis....less than one percent do.   those who do get paralysis have a 50% chance to develop a post-polio syndrome which appears to be autoimmune in nature.  Does this mean that polio paralysis functions in a similar manner? striking paralysis only in those with a staph infection at the same time?

Hopkin's syndrome
http://link.springer.com/article/10.1007/BF02962374#page-1
this autoimmune disease needs be looked at again and compared to what we are seeing
http://www.ncbi.nlm.nih.gov/pubmed/3508063
http://www.ncbi.nlm.nih.gov/pubmed/20117751

Parkinsonism, seborrhoeic dermatitis, and cross-targeting autoimmunity?

Autoimmune cross-targeting hypothesis: that the layering of 2 infections on one target confuses the immune system into autoimmune attack.  A viral infection like the flu H1N1 marks the inside and something marks the outside of the nerves in Parkinsonisms.

seborrhoeic dermatitis, parkinsonism, and Pityrosporum ovale
http://www.ncbi.nlm.nih.gov/pubmed/8042441

seborrhoeic dermatitis and malassezia fungus
http://www.ncbi.nlm.nih.gov/pubmed/10535248
http://www.ncbi.nlm.nih.gov/pubmed/16398968

Parkinson's and seborrhoeic (misdiagnosed?)
http://www.ncbi.nlm.nih.gov/pubmed/24628775
http://www.ncbi.nlm.nih.gov/pubmed/12699724
http://www.ncbi.nlm.nih.gov/pubmed/14678527

Parkinsonism and gluten
http://www.ncbi.nlm.nih.gov/pubmed/24464413
http://www.ncbi.nlm.nih.gov/pubmed/12628066

vitiligo/cafe au lait spots and parkinsonism
http://www.ncbi.nlm.nih.gov/pubmed/668253
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1673696/
http://www.ncbi.nlm.nih.gov/pubmed/5164553
http://www.ncbi.nlm.nih.gov/pubmed/5164553

I have regular parkinson's associated with psoriasis, a mycobacteria, and a flu virus on previous posts.
The flu virus could be the same one.

H1N1 has triggered so many autoimmune reactions it is always at the top of the list.

Gluten how does it alter the immune system during a barrier breaking infection????

What does gluten do if it is not a serpin inhibiting the dimorphic changes in infections?  This blog will attempt to contemplate some possibilities.

Gluten appears with barrier breaking infections:
e.coli
strep
candida
t.gondii
sutterella
mycobacterias

These infections break through barriers but how does gluten makes the situation worse?

 How similar is the intestinal and the blood brain barrier's immune system? Nature does conserve what works.....


New paper linking intestinal lumen and the BBB. When the intestine becomes stronger so does the BBB.
http://www.ncbi.nlm.nih.gov/pubmed/25411471

Zonulin is also an interesting dimension appearing at the lumen of the gut and the blood brain barrier
http://www.ncbi.nlm.nih.gov/pubmed/23637756
http://www.ncbi.nlm.nih.gov/pubmed/22731712

IFN-γ participates in cerebral malaria pathogenesis by affecting endothelial 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133756

IFN temporary bbb crossing blocked but long term opens it?
http://www.researchgate.net/publication/5257154_Interferon-beta_prevents_cytokine-induced_neutrophil_infiltration_and_attenuates_blood-brain_barrier_disruption

Gluten stimulates more IFN-gamma expression
http://www.gastrojournal.org/article/S0016-5085%2898%2970134-9/abstract 

gluten stimulates macrophages/monocytes
http://www.ncbi.nlm.nih.gov/pubmed/11927649
http://www.ncbi.nlm.nih.gov/pubmed/15280021
http://www.ncbi.nlm.nih.gov/pubmed/17260166

gluten causes dentritic maturation not just stimulation
http://www.ncbi.nlm.nih.gov/pubmed/16272365

gluten and enterocyte proliferation pathway messed up? the intestine can't repair?
http://www.ncbi.nlm.nih.gov/pubmed/23966426
http://www.ncbi.nlm.nih.gov/pubmed/24204586

growth factor like ability of gluten? gliadin effects EGF???

http://www.ncbi.nlm.nih.gov/pubmed/16891357
http://www.ncbi.nlm.nih.gov/pubmed/23966426

Weird full circle....
Were they looking because of this? Neuroserpin alters EGF????
http://www.ncbi.nlm.nih.gov/pubmed/12354288

Is gluten a serpin like i originally guessed? only it effects us not the infection?
Were they looking because of this? Neuroserpin alters EGF???? is it not a serpin?
http://www.ncbi.nlm.nih.gov/pubmed/12354288

my older post has some similar links.....
http://angelabiggs.blogspot.com/2014/09/if-all-gluten-and-casein-senstive.html

Is the citrulline antibodies of RA occur because of the mycoplasmas?

Citrulline antibodies specific for RA
http://www.ncbi.nlm.nih.gov/pubmed/19725967
http://www.ncbi.nlm.nih.gov/pubmed/16651702

sputum with antibodies in patients with RA
http://www.ncbi.nlm.nih.gov/pubmed/23817979

RA, citrulline, and joints
https://books.google.com/books?id=1FmPBl5C9kcC&pg=PA308&dq=-cyclic+citrullinated+peptide+viral&hl=en&sa=X&ei=VHqtVMSYO4qSyQTy0IGwAg&ved=0CDIQ6AEwAA#v=onepage&q=-cyclic%20citrullinated%20peptide%20viral&f=false

Citrulline and human mycoplasmas
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC213594/?page=1

Mycoplasma pneuomoniae does gliding
http://www.ncbi.nlm.nih.gov/pubmed/23396910

Hepatitis  C with RA
http://www.ncbi.nlm.nih.gov/pubmed/25415338

Liver and citrulline
http://www.ncbi.nlm.nih.gov/pubmed/23145208

Mycoplasmas, hepatitis c  and the liver
http://www.ncbi.nlm.nih.gov/pubmed/23163121

one-third of people with Hepatitis C will have arthritis...are these the people with mycoplasmas? Do these the people who develop autoimmune liver disease?

RA and autoimmune liver disease
http://arthritis-research.com/content/13/3/226


note that hepatitis B has been found to infect the joints at the same time as the liver and cause joint pain before the jaundice even appears
http://pmj.bmj.com/content/61/716/545.full.pdf
Does hepatitis C infect the joints or does it just cause joint inflammation?

Previous post of how cross-targeting causes RA through 2 infections:
http://angelabiggs.blogspot.com/2014/11/autoimmune-cross-targeting-could-cause.html