Hypotheses: Autoimmune Cross-targeting, Co-carcinogenesis, and Quorum complications : November 2014

Tuesday, November 25, 2014

Buerger's disease ( thromboangiitis obliterans)...can it be caused by autoimmune cross-targeting?

Not to be confused with Berger's disease (IgA nephropathy)

Buerger's disease or thromboangiitis obliterans is an autoimmune disease of the vascular system.
http://www.ncbi.nlm.nih.gov/pubmed/2808505
http://www.ncbi.nlm.nih.gov/pubmed/6392910

Hypothesis: The cross-targeting of infections at the same tissue causes autoimmune disease. One infection marks the outside while another marks the inside...only then does the immune system become confused and attack. A virus marks the inside of the vascular cells while an infection marks the outside.

Is it Rickettsia?
http://www.ncbi.nlm.nih.gov/pubmed/21803838
http://www.ncbi.nlm.nih.gov/pubmed/6897655
http://www.ncbi.nlm.nih.gov/pubmed/6893791

Rocky mountain spotted fever, rickettsia, and kidney failure
http://www.ncbi.nlm.nih.gov/pubmed/434998
http://www.ncbi.nlm.nih.gov/pubmed/1996579
http://www.ncbi.nlm.nih.gov/pubmed/9003109

Gangrene and Rocky mountain spotted fever
http://www.ncbi.nlm.nih.gov/pubmed/8507753
http://www.ncbi.nlm.nih.gov/pubmed/7748070

IMPORTANT: Tobacco use can cause antibodies which may mean this is the first autoimmune disease that may not require 2 infections for cross-targeting to occur!!!
http://www.ncbi.nlm.nih.gov/pubmed/1598672
http://www.ncbi.nlm.nih.gov/pubmed/6426348

smokeless tobacco extract changes vascular cells
http://www.ncbi.nlm.nih.gov/pubmed/10708806

So the parasite would make the outside and the tobacco chemical would mark the inside?

Here is a Virus triggering the Buerger's: Coxsackie virus

http://www.ncbi.nlm.nih.gov/pubmed/2868678

Buerger's overlaps with takayasu and juvenile arthritis

http://www.ncbi.nlm.nih.gov/pubmed/9951798
http://www.ncbi.nlm.nih.gov/pubmed/13679660

Mycobacteria and juvenile arthritis mice?????? not sure where i am
http://www.ncbi.nlm.nih.gov/pubmed/24470407

Sunday, November 23, 2014

Autoimmune cross-targeting could cause Rheumatoid arthritis

Autoimmune cross-targeting hypothesis: that the layering of 2 infections on one target confuses the immune system into autoimmune attack. A viral infection like hepatitis marks the inside and mycoplasmas mark the outside in the case of RA.

Mycoplasmas and RA
http://www.ncbi.nlm.nih.gov/pubmed/24097830
http://www.ncbi.nlm.nih.gov/pubmed/10618069 (infection found in synovial fluid)
http://www.ncbi.nlm.nih.gov/pubmed/17122006

Not a new idea 1971...mycoplasmas and RA
http://www.ncbi.nlm.nih.gov/pubmed/5165178

Synovial membrane antibodies and RA
http://www.ncbi.nlm.nih.gov/pubmed/16184347

Virus: hepatitis and RA
http://www.ncbi.nlm.nih.gov/pubmed/25415338
http://rheumatology.oxfordjournals.org/content/38/10/978.full (after hepatitis vaccine RA)

Virus: epstein barr and RA
http://www.ncbi.nlm.nih.gov/pubmed/25407647

Note that it is the target and the layering of infections pointing the immune system at the target that is is important in the development of autoimmunity. Either virus could trigger the event.

Older posts
http://angelabiggs.blogspot.com/2014/09/ra-stroke-irregular-heartbeats-and.html
http://angelabiggs.blogspot.com/2013/04/lupus-and-ra-leukemia-and-mycoplasmas.html

Thursday, November 20, 2014

Vaccines and autoimmune disease: the viruses are only half the issue and this cross-targeting hypothesis will help find the other culprits.

GET VACCINATED !!!!! This blog believes that preventing viral infection is your best defense.

Cross-targeting hypothesis: the immune system must cross-target itself on one target with 2 different infections before it is willing to attack self. Autoimmunity develops only when a virus is layered on top of another infection thus confusing the immune system.

Example: mycoplasmas of RA infect the pancreas and then the flu virus replicates there triggering the autoimmunity...or e.coli make anti-insulin antibodies and then the flu replicates there....causing type 1 diabetes.

Possible? If this is true we need to know what infections existed in the target tissue of the people who develop autoimmunity after vaccines. Does sutterellla the bacteria suspect in some autistic children hang out in the same nerves that the measles vaccine targets? Sutterella has been found in the brain. Very few areas in the us will have an issue with the vaccine triggered form of autism most will be antibodies from the mother which cause the autism. Sutterella is found in areas where the sewers over flow into the areas waters.....NOT COMMON.

Note that it is the antibodies from the vaccines that can trigger the autoimmune disease. A good vaccine won't have them....this should be preventable if you know what you are looking for.

This Blog post will slowly try to collect information about the vaccine triggered autoimmune diseases and will be updated over time. Note that when a vaccine has issues...they are not used and improved.

Yellow fever vaccine
http://www.hindawi.com/journals/ad/2014/473170/

HPV
http://www.ncbi.nlm.nih.gov/pubmed/25388965

hepatitis vaccine
http://www.ncbi.nlm.nih.gov/pubmed/22235045
http://www.ncbi.nlm.nih.gov/pubmed/25042822 (murine model)
http://rheumatology.oxfordjournals.org/content/38/10/978.full (RA after hepatitis vaccine)

H1N1
http://www.ncbi.nlm.nih.gov/pubmed/21994316
http://www.ncbi.nlm.nih.gov/pubmed/23498095

MMR and autism...the confusion
http://www.ncbi.nlm.nih.gov/pubmed/11331734

Tuesday, November 18, 2014

autoimmune cross-targeting and Meniere's disease of the inner ear

Hypothesis: The cross-targeting of infections at the same tissue causes autoimmune disease. One infection marks the outside while another marks the inside...only then does the immune system become confused and attack. A virus like herpes marks the inside of the cell while an infection such as candida marks the outside....the target cell in this case is the labyrinthectomy or vestibular nerve of the inner ear.

There could be more than one infection that triggers. The Key is one must be a virus and one an outer infection.

Meniere's as an autoimmune disease

http://www.sciencedirect.com/science/article/pii/S1568997212000092

gluten with candida not celiac
http://www.ncbi.nlm.nih.gov/pubmed/19549274
http://www.ncbi.nlm.nih.gov/pubmed/12383098

(note that for a while on this blog I thought gluten/casein indicated a dimorphic infection but LON the enzyme responsible for switching is not gluten sensitive so the new hypothesis that gluten and casein cause inflammation in barrier crossing infections.)

Hypothyroid with meniere's
http://www.ncbi.nlm.nih.gov/pubmed/14967756

blog post connecting Hashimoto's thyroid, sjogren's, and asperger's (fungal)
http://angelabiggs.blogspot.com/2013/08/aspergers-sjogren-and-hosimotos-overlap.html

Sjogren's, water channels, and meniere's
http://www.ncbi.nlm.nih.gov/pubmed/22732097
http://www.ncbi.nlm.nih.gov/pubmed/19096777
http://www.ncbi.nlm.nih.gov/pubmed/16974147
http://www.ncbi.nlm.nih.gov/pubmed/23382834

Candida, biofilms and waterchannels (biofilm is how it sticks to the walls)
http://www.ncbi.nlm.nih.gov/pubmed/15496122
http://www.ncbi.nlm.nih.gov/pubmed/11526156

Dividing up: Autistic development disorders, adhd, and asperger's

Hypothesis: These will be found to be autoimmune diseases caused initially by cross-targeting autoimmunity.

At least 4-5 types of development disorders exist: Immediate autism, regressive autism, ADHD, and asperger's

Immediate Autism: has seizures, anxiety, delayed or absent development of social skills. (In this case the child is born with autism and the frontal lobe has antibodies against it and grows abnormally.

rheumatoid arthritis in mother's and autism
http://www.ncbi.nlm.nih.gov/pubmed/19581261 (lupus?)
http://www.ncbi.nlm.nih.gov/pubmed/10385847
http://sfari.org/news-and-opinion/news/2013/large-study-links-autism-to-autoimmune-disease-in-mothers
http://www.ncbi.nlm.nih.gov/pubmed/23958959
http://www.ncbi.nlm.nih.gov/pubmed/23910451

Lupus seems connected to dyslexia
http://www.ncbi.nlm.nih.gov/pubmed/3205905
http://www.ncbi.nlm.nih.gov/pubmed/18593761

Newer post looks at seizures and and lupus as possibly caused by antibodies.

Posts of mine connecting RA,lupus and mycoplasmas
http://angelabiggs.blogspot.com/2014/11/autoimmune-cross-targeting-could-cause.html
http://angelabiggs.blogspot.com/2013/04/lupus-and-ra-leukemia-and-mycoplasmas.html
http://angelabiggs.blogspot.com/2014/09/ra-stroke-irregular-heartbeats-and.html

bipolar with autism (not depression or hypothyroid rather hyperthyroid)
http://www.ncbi.nlm.nih.gov/pubmed/18378000

In this case mother's autoimmunity attacks child's brain
http://www.ncbi.nlm.nih.gov/pubmed/23958959
http://www.ncbi.nlm.nih.gov/pubmed/18571628
http://www.ncbi.nlm.nih.gov/pubmed/18078998

Regressive autism: Childhood disintegrative disorder is when the child suddenly loses skills after viral trigger (or vaccine) which is a very small group.

Are there 2 groups here? gluten sensitive sutterella group which reacted to the MMR then the hearing impaired group which reacted to the DTP? Please see the new posts where I have divided these up better.

Group one: MMR and sutterella cross-targeting on the cerebellum. Ataxia issues are involved.
Is this the sutterella group with the clusters in NJ and Hawaii? where the sewers are overflowing and a fecal bacteria could spread) Autoimmune cross-targeting form of autism where the nerves targeting by the vaccine are the same ones the sutterella likes. (sutterella exists in intestine and has been found in brain
http://www.ncbi.nlm.nih.gov/pubmed/24188502
http://www.ncbi.nlm.nih.gov/pubmed/19027584 (children have intestinal issues)

Sutterella is rare....get your kids VACCINATED

only the kids with sutterella bacteria would react with the vaccine...through cross-targeting autoimmunity
http://www.ncbi.nlm.nih.gov/pubmed/11331734

My old post on Autism and sutterella might not be correct because the Lon enzyme has been tested and it is not morphology change from gluten.
http://angelabiggs.blogspot.com/2013/07/is-sutterella-dimorphic.html
The new post about gluten and casein considers sutterella as breaking the intestinal and brain barriers.
http://angelabiggs.blogspot.com/2014/09/if-all-gluten-and-casein-senstive.html

Group 2 regressive: the DTP and 6th disease cross-targeting on the temporal lobe. Hearing issues are involved. See new post.

ADHD is when the child has hyperactivity, tics, and attention issues...Eczema and staph?

ADD and bipolar
http://www.ncbi.nlm.nih.gov/pubmed/9680053

ADHD and tics ( if tourettes is triggered by strep what is this staph?)
http://www.ncbi.nlm.nih.gov/pubmed/14580223
http://www.ncbi.nlm.nih.gov/pubmed/16780292

ADHD with asthma and allergies
http://www.brainbalancecenters.com/blog/2013/08/study-adhd-linked-to-asthma-and-allergies/
ADHD with eczema which could be staph
http://www.everydayhealth.com/eczema/the-eczema-and-adhd-connection.aspx
http://www.ncbi.nlm.nih.gov/pubmed/24289041

Autism and hyperactivity
http://www.ncbi.nlm.nih.gov/pubmed/17201617

Asperger's has hypothyroid, sjogren's and fungal infection connections
antisocial but gifted abilities in math, music, or art
unusual speech patterns and sensitive to smell or touch

ADHD and hypothyroid
http://www.ncbi.nlm.nih.gov/pubmed/12573298
not linked to hyper trait

Antisocial and substance abuse
http://www.ncbi.nlm.nih.gov/pubmed/19515234

asperger's and hashimoto's the older post
http://angelabiggs.blogspot.com/2013/08/aspergers-sjogren-and-hosimotos-overlap.html

asperger's and bipolar
http://www.ncbi.nlm.nih.gov/pubmed/25046741

Pervasive developmental disorder is when the child has developmental delays but too social to be autistic ...seems like this would fall into the adhd group??

Friday, November 7, 2014

Overlap of Mycobacterias, type 2 diabetes, crohn's, parkinson's, and psoriasis

Tuesday, November 4, 2014

3 types of Schizophrenia : 2 are cross-targeting autoimmunity and one is tumor created antibodies

This blog focuses primarily on cross-targeting autoimmunity. In the case of schizophrenia it has become apparent that at least 2 types exist that involve infections cross-targeting with viral infections.

Fungal infections could cause manifest with other autoimmune diseases like Sjogern's, Asperger's, and Hashimotos thyroid. These fungal infections are dimorphic thus causing the person to have sensitivities to corn, soy, and estrogen. Dimorphic means that they shift as a fungal infection between a yeast and a mold state of morphology. An example of a fungal infection is Candida. The fungal infection might break the blood brain barrier allowing a virus like cmv into the brain. The key is that these ,unlike T.gondii, would be estrogen sensitive.

Schizophrenia has also been associated with T.gondii infections which trigger strong gluten and casein sensitivities. There appears to be gluten and casein sensitivities when small infections cross barriers like the intestine or the blood brain barrier....or at least that is my prediction.

I had contrasted Asperger's and schizophrenia looking at both of these infections before.
http://angelabiggs.blogspot.com/2014/04/aspergers-and-schizophernia-both.html
asperger's with schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/23065028
http://link.springer.com/article/10.1007%2Fs00787-012-0338-x#page-1

This page is under construction as I organize references and explain my thoughts for linking them.

The Cross-targeting hypothesis: when a viral infection overlaps a basic infection on/in one cell type, in this case neurons, thus confusing the immune system and generating an autoimmune attack against self.

First Schizophrenia has 2 core autoimmune antibodies:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065649/
Voltage gated potassium channels and then the NMDA receptor. The larger infections tend to generate these antibodies while the viruses tend to infect the neurons themselves....except the flu which does generate even in vaccine form antibodies against neurons.

The anti-voltage gated potassium channel is responsible for hallucinations
anti-voltage-gated potassium channel antibodies associated encephalopathy is autoimmune
http://www.ncbi.nlm.nih.gov/pubmed/14960497
anti-voltage-gated potassium channel antibodies and auditory hallucinations
http://www.ncbi.nlm.nih.gov/pubmed/24571022
vgkc antibodies and seizures in cats
http://www.ncbi.nlm.nih.gov/pubmed/23278981
vgkc and children
http://www.ncbi.nlm.nih.gov/pubmed/21464429
potassium flow in schizophrenia and gene for the potassium channel
http://www.nih.gov/news/health/may2009/nimh-05.htm

The NMDA receptor seems to cause the mania, seizures, paranoia, and catatonic symptoms after flu like fevers
http://www.ncbi.nlm.nih.gov/pubmed/24731834
http://www.ncbi.nlm.nih.gov/pubmed/18807939
NMDA and narcolepsy
http://www.ncbi.nlm.nih.gov/pubmed/22569157
http://www.ncbi.nlm.nih.gov/pubmed/18446324
http://www.ncbi.nlm.nih.gov/pubmed/12611960

NMDA and fear
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263393/

The fungal kind of schizophrenia:

Hashimotos and encephalopathy
http://www.ncbi.nlm.nih.gov/pubmed/25116126
http://www.ncbi.nlm.nih.gov/pubmed/22474467 (with hallucinations)
autoantibodies against the NH2-terminal of a-enolase (NAE) as a specific diagnostic marker for HE
http://www.ncbi.nlm.nih.gov/pubmed/19363998
http://www.ncbi.nlm.nih.gov/pubmed/17335908

Hashimotos and voltage gated potassium channels are different from encephalopathy?
http://www.ncbi.nlm.nih.gov/pubmed/1507901

SJ and Schizophrenia
http://www.researchgate.net/publication/232431729_Relation_between_schizophrenic-like_psychosis_and_Sjogren's_syndrome_(SS)
http://www.ncbi.nlm.nih.gov/pubmed/3679782
http://www.ncbi.nlm.nih.gov/pubmed/22442099
http://www.ncbi.nlm.nih.gov/pubmed/16513876
http://www.hcplive.com/articles/Autoimmune-Disease-Schizophrenia-and-Bipolar-Disorder

NMDA and Sjogren's
http://www.ncbi.nlm.nih.gov/pubmed/15708887
http://www.ncbi.nlm.nih.gov/pubmed/16868971

Potassium deficiency and Candida...does this cause the malfunction of the channel?
http://www.livestrong.com/article/335327-potassium-deficiency-candida/

The T.gondii kind of schizophrenia:

t.gondii and encephal
http://en.wikipedia.org/wiki/Toxoplasmosis
http://www.ncbi.nlm.nih.gov/pubmed/14725265

Gluten and casein with schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/25241021

anti-gluten after t.gondii infects mice
http://www.ncbi.nlm.nih.gov/pubmed/23209841

schizophrenia and gluten sensitivity
http://www.ncbi.nlm.nih.gov/pubmed/22446142

malaria parasite and the potassium channel
http://www.science20.com/news_releases/disrupting_potassium_channel_in_malaria_parasite_blocks_transmission

T.gondii infects like the malaria parasite and involves the potassium channel? ???
http://www.science20.com/news_articles/toxoplasma_gondii_study_turns_parasite_invasion_theory_its_head-99796

My Older post of pan-apple domains, t.gondii, and the NMDA receptor

In our body when blood clots are degraded, plasminogen which has the PAN sequence in it, is activated by tPA (tissue plasminogen activator)

t-PA binds not just plasminogen but the NMDA receptor. Does this mean the NMDA receptor has a PAN/apple domain?

ref: t-PA is a new ligand of NMDA receptor
JBC papers Sept 23. 2004

t.gondii and pan-apple
http://connection.ebscohost.com/c/articles/77507454/novel-pan-apple-domain-containing-protein-from-toxoplasma-gondii-characterization-receptor-identification

If antibodies develop against T.gondii included the pan/apple domain does this mean the antibodies might also bind the NMDA receptor? and the over stimulation of the receptor would mean down regulation and hence the loss of fear initially seen?

CMV virus inhibits the expression of NMDA
http://www.ncbi.nlm.nih.gov/pubmed/15759129

viral infections or drugs are under consideration for the cross-targeting

the flu virus during pregnancy and schizophrenia
http://www.schizophrenia.com/prevention/maternal.html
the flu vaccine and narcolepsy which might overlap schizo
http://www.ncbi.nlm.nih.gov/pubmed/24849861
http://www.newscientist.com/article/dn24772-flu-vaccine-helps-unravel-complex-causes-of-narcolepsy.html#.VFo6_fnF-So

herpes virus 6 and 8 (these infect the neurons themselves and because they damage the mitochondria this might overlap with alzheimer's)
http://www.ncbi.nlm.nih.gov/pubmed/24139899
http://www.ncbi.nlm.nih.gov/pubmed/14991372
http://www.ncbi.nlm.nih.gov/pubmed/?term=herpesvirus+8+schizophrenia+2013
http://www.uptodate.com/contents/human-herpesvirus-6-infection-in-hematopoietic-cell-transplant-recipients
http://www.ncbi.nlm.nih.gov/pubmed/17981263

herpes 6 can reactivate cmv
http://jid.oxfordjournals.org/content/181/4/1450.long

CMV (Cytomegalovirus, also known as HCMV, CMV or Human Herpes virus 5 (HHV-5) )
http://www.ncbi.nlm.nih.gov/pubmed/24083998
http://www.ncbi.nlm.nih.gov/pubmed/25351544

Herv W
http://www.ncbi.nlm.nih.gov/pubmed/20100784
special note that T.gondii is currently under investigation for awakening herv
http://www.ncbi.nlm.nih.gov/pubmed/17054075
in other words T.gondii may create it's own cross-targeting reaction as part of the mind control

HIV?
http://www.ncbi.nlm.nih.gov/pubmed/11394192

Paranoid schizophrenia could be caused by dopamine high activity in the hippocampus
http://www.ncbi.nlm.nih.gov/pubmed/1349833

Meth causes dopamine disfunction of the hippocampus
http://www.ncbi.nlm.nih.gov/pubmed/20074221

cannabis and schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/16319402
http://www.ncbi.nlm.nih.gov/pubmed/10881971

extra note about t.gondii
http://www.ncbi.nlm.nih.gov/pubmed/11429165

Hypotheses: Autoimmune Cross-targeting, Co-carcinogenesis, and Quorum complications