ALS and cross-targeting autoimmunity

ALS: Is the spontaneous form triggered by cross-targeting?

link to newer over view post
http://angelabiggs.blogspot.com/2015/02/over-view-of-brain-autoimmunity.html

Hypothesis: Cross-targeting autoimmunity occurs when 2 infections, one being a virus, infect the same target.  (or generate antibodies against the same target) This state causes the immune system to escalate the immune attack into autoimmunity because both the inside and the outside of the organ is marked as infected.

ALS is an autoimmune disease where 60% of spontaneous cases have antibodies against calcium channels.

http://www.ncbi.nlm.nih.gov/pubmed/8109897
http://www.ncbi.nlm.nih.gov/pubmed/1331790
http://www.ncbi.nlm.nih.gov/pubmed/7818241

Previously I looked at ALS, picks disease, and trichophyton.
 http://angelabiggs.blogspot.com/2013/09/picks-disease-and-als-and-blastomyces.html

Trichophyton is a type of blastomyces which when it infects dogs they are identified by an increase in blood calcium levels.  Is this true for people? Do calcium levels go up? http://www.dermatologyforanimals.com/faq-07/

Blastomyces are a type of fungal infection that can survive without iron as long as it has high calcium available.

Why am I looking at Trichophyton as a trigger for ALS? It is a fungal infection associated with athletes foot and it is involved with the decomposing of rotting wood and exists in high levels around the great lakes which has several ALS clusters.  Blastomyces has a high affinity for high calcium so I am looking at the EF hands involved with the calcium channels and how Trichophton grabs calcium. Is there a connection here?

The key here is that I must find a virus that infects the same neurons that the calcium channels have been marked on....specifically the neurons that are attacked in als.

Review of viruses indicates herv-k
http://www.ncbi.nlm.nih.gov/pubmed/23707220
the problem is we don't know what awakens herv

note that drinking coffee seems to lower the chances of ALS
http://aje.oxfordjournals.org/content/early/2011/10/18/aje.kwr229.full

Caffeine seems to inhibit DNA repair and inhibits retroviruses like HIV and Herv
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC546572/

Both HIV and herv have been associated with ALS

HIV and ALS like syndromes
http://www.ncbi.nlm.nih.gov/pubmed/2561585
http://www.ncbi.nlm.nih.gov/pubmed/24842949
http://www.ncbi.nlm.nih.gov/pubmed/23931799

Herv reactivation notions: are bacterial infections involved?
http://www.nature.com/nature/journal/v491/n7426/abs/nature11599.html 

Now looking into Felines (cats) , retroviruses, and Blastomyces
http://books.google.com/books?id=RrSvvcWLpmgC&pg=PT213&lpg=PT213&dq=blastomycosis++feline+retrovirus&source=bl&ots=GUHcbNorBA&sig=wUE0BaB36l1lwlq7llysQfOe158&hl=en&sa=X&ei=kdADVLcawsCCBJKsgfgJ&ved=0CC4Q6AEwAQ#v=onepage&q=blastomycosis%20%20feline%20retrovirus&f=false


WOW....in the past i looked at t.gondii and herv because schizophernia has high levels of herv involved: i just found this article
http://www.ncbi.nlm.nih.gov/pubmed/17054075   (we need to look at blastomyces more when it comes to herv)

Here is my older post:http://angelabiggs.blogspot.com/2013/05/lou-gehrigs-disease-and.html

neuromyelitis optica and cross-targeting autoimmunity

Neuromyelitis optica (Devic's disease) is a demyelinating disease of the central nervous system that preferentially affects the optic nerve and spinal cord. Once thought to be a type of MS but now considered a separate disease.

Hypothesis: Cross-targeting autoimmunity occurs when 2 infections, one being a virus, infect the same target.  This state causes the immune system to escalate the immune attack into autoimmunity because both the inside and the outside of the organ is marked as infected.

culprits for neuromyelitis optica : influenza A and candida or influenza and mycoplasmas?

influenza A and neuromyelitisoptica
http://www.ncbi.nlm.nih.gov/pubmed/21804290
This could explain the narcolepsy group
http://www.ncbi.nlm.nih.gov/pubmed/22777080
Flu vaccine and narcolepsy
http://www.ncbi.nlm.nih.gov/pubmed/24849861
Narcolepsy and candida
http://www.ncbi.nlm.nih.gov/pubmed/?term=candida+narcolepsy
Narcolepsy and hypocretin neurons
http://healthysleep.med.harvard.edu/narcolepsy/what-is-narcolepsy/science-of-narcolepsy

does strep cause the narcolepsy version?
http://www.aasmnet.org/jcsm/ViewAbstract.aspx?pid=28864
by letting the antibodies across against mycoplamsas or fungus? 2 autoimmune diseases together?


Candida? Sjogren connection to neuromyelitisoptica
http://www.ncbi.nlm.nih.gov/pubmed/20235486
http://www.ncbi.nlm.nih.gov/pubmed/20120352
I am currently looking at other fungal infections that are known to grow along the the spine

Older post of mine with Candida, sjogren, Hashimotos
http://angelabiggs.blogspot.com/2013/08/aspergers-sjogren-and-hosimotos-overlap.html 

Second culprit: Mycoplasma, lupus,but still the flu virus

neuromyelitisoptica  and lupus
http://www.ncbi.nlm.nih.gov/pubmed/24948869
http://www.ncbi.nlm.nih.gov/pubmed/19745613

neuromyelitisoptica  and mycoplasmas
http://www.ncbi.nlm.nih.gov/pubmed/24557856
http://www.ncbi.nlm.nih.gov/pubmed/19497587
http://www.ncbi.nlm.nih.gov/pubmed/18563469

MY older post of lupus/RA and mycoplasmas
http://angelabiggs.blogspot.com/2013/04/lupus-and-ra-leukemia-and-mycoplasmas.html

 What are the other considerations:

Asian multiple sclerosis is actually neuromyelitisoptica not MS
http://www.ncbi.nlm.nih.gov/pubmed/18990121 
http://www.ncbi.nlm.nih.gov/pubmed/21962794


The overlap of lupus and sjogren's must be addressed.  Both conditions have anti-phospolipids which I previously suggested had to do with these infections using high levels of biofilms to stick them onto the phospholipid bilayer. Mycoplasmas as the smallest type of infection and fungal as the largest.
I had surmised that the immune system releases extra phospholipids in an attempt to get these off the cell walls.  http://angelabiggs.blogspot.com/2013/12/antiphospholipids-and-infections-with.html

Extra phospholipids may not only cause anti-phospholipid antibodies but the lipids could be triggering water channels.  here is an indirect example of a water channel altered by lipids: http://www.ncbi.nlm.nih.gov/pubmed/23680159

A bit of an extrapolation but what if the lipids used by the immune system messed up the water channels of the infection and made them visible to the immune system?

Aquaporin 4 in sensory neurons
http://chemse.oxfordjournals.org/content/33/5/481.full.pdf

Anti-aquaporin in neuromyelitisoptica
http://www.ncbi.nlm.nih.gov/pubmed/25160125

Aquaporin 4 cross-immunoreactivity with aquaporin Z
http://www.ncbi.nlm.nih.gov/pubmed/23008451

which infections have aquaporin Z? candida does have one but not Z....same for a mycoplasma
http://www.medizin.uni-greifswald.de/funkgenom/teaching/100114-V12-1-Osmosensing-Lit/Tanghe%20et%20al.%202006-Trends%20Microbiol.pdf
does the aquaporin they have cross-immunoreact?

interesting article: mycoplasma, NMO, and anti-aquaporin 
http://www.ncbi.nlm.nih.gov/pubmed/194975

my gut is telling me there exists a  connection between the phospholipids and the aquaporins...the biofilms?

Looking at the water channels of biofilms
http://www.ncbi.nlm.nih.gov/pubmed/23271809

HERE IT IS: aquaporins help to form biofilms is addressed in this book!
http://www.sciencedirect.com/science/journal/03044165/1840/5   

Summary: mycoplasmas or fungal infections make an obscene amount of biofilm which our immune system develops antibodies to.  (anti-aquaporin is produced because they would stand out in the biofilm ) anti-aquaporins would target our cells with aquaporin4 but autoimmunity would only occur when a virus infects these specific cells with aquaporin4.  The immune system has cross-targeted the cell....antibody marking the outside and virus marking the inside driving the autoimmunity to begin.

good hypothesis but not proven

Gluten and casein

Schizophrenia's t.gondii...is not dimorphic? but it triggers the gluten response?
http://www.ncbi.nlm.nih.gov/pubmed/23209841

I need to rethink things. 

Staph makes a pigment with egg or milk which explains the milk and egg allergy of eczema

Candida does dimorphic switching with corn, milk, and soy/ estrogen.  Does it with gluten?

Perhaps when t.gondii breaks across barriers or cells it makes a long tube like structure.

I had thought that E.coli, sutterella, mycobacteria, and even t.gondii changed morphology with gluten and casein but when i had the LON enzyme looked at in E.coli it was not responsive to gluten.  Is it a different enzyme or is it not a morphology issue? ahhhh....