Ulcerative colitis & C. sordellii?

Intestinal infections can develop into autoimmune disease: E.coli can turn into Celiac disease and Sutterella can turn into Autism when a secondary virus causes cross-targeting.

 I wonder if  other infections like the mycobacteria associated with crohn's  or he C. diff developing into ulcerative colitis...have the potential to become autoimmune disease.  I think these are considered inflammation states. (like psoriasis and eczema of the skin)  I will be researching for overlapping autoimmune disorders.

This page is still under construction.

Ulcerative colitis and c. diff
http://www.ncbi.nlm.nih.gov/pubmed/22508484
http://www.ncbi.nlm.nih.gov/pubmed/18484669
http://www.ncbi.nlm.nih.gov/pubmed/19913210
http://www.ncbi.nlm.nih.gov/pubmed/19944802
http://www.ncbi.nlm.nih.gov/pubmed/21915178
http://www.ncbi.nlm.nih.gov/pubmed/22405170

allergy and ulcerative colitis
http://www.ncbi.nlm.nih.gov/pubmed/10912663

Leukocytes and c. diff
http://www.ncbi.nlm.nih.gov/pubmed/22421720

C.diff appearing in low risk populations outside the hospital
http://www.ncbi.nlm.nih.gov/pubmed/17482995 

My thoughts....c.diff may not really be the culprit. C. sordellii which is closely related makes urease like H. Pylori.  H. pylori we know causes ulcers.

I wish I could tell if c.sordellii is one of the few that can use Casein.
 http://www.bd.com/ds/productCenter/221858.asp

Other thoughts:
Daisy/chamomile allergy
The natural treatment of ulcerative colitis is chamomile and people I know with ulcerative colitis have Daisy/mum/chamomile allergies. I wonder what is going on.  There are more thoughts on the earlier ulcerative colitis page

Mycobacteria Diseases: Psoriasis, Crohn's, Parkinson's, Panda's, type 2 diabetes ? Cross-targeting autoimmune diseases ?

Autoimmune Hypothesis: 2 infections cross-target to trigger autoimmune disease. When Mycobacterias are the initial infection the autoimmune disease that develops depends on which virus is there to do the cross-targeting. All of these are mycobacteria diseases but not all of them are autoimmune; some are just inflammation.

Crohn's: Mycobacteria and norovirus like virus cross-targeting the intestine or is it just mycobacteria alone?
http://www.ncbi.nlm.nih.gov/pubmed/23128233
http://www.ncbi.nlm.nih.gov/pubmed/9228475
http://www.ncbi.nlm.nih.gov/pubmed/8174989
http://www.ncbi.nlm.nih.gov/pubmed/23971052  (psoriasis and IBS)

similarity between crohn's and Johne's disease
http://www.ncbi.nlm.nih.gov/pubmed/24494172

Psoriasis: Mycobacteria  this not an autoimmune disease just inflammation of the skin from mycobacteria
http://www.ncbi.nlm.nih.gov/pubmed/23675972
http://www.ncbi.nlm.nih.gov/pubmed/23278714
http://www.ncbi.nlm.nih.gov/pubmed/23157912
http://www.ncbi.nlm.nih.gov/pubmed/23036486
http://www.ncbi.nlm.nih.gov/pubmed/22208431 
http://www.ncbi.nlm.nih.gov/pubmed/24050284

Psoriatic arthritis and mycobacterias...could be autoimmune so i will look for a virus next.
http://www.ncbi.nlm.nih.gov/pubmed/22751601
http://www.ncbi.nlm.nih.gov/pubmed/23473929
http://www.ncbi.nlm.nih.gov/pubmed/22413775
http://www.ncbi.nlm.nih.gov/pubmed/22208431

Parkinson's: Mycobacteria (called Nocardia?) crossed over the bloodbrain barrier then a bird flu virus  H5NI then must trigger the cross-targeing of the immune system
Looking for references, this is close:
http://www.ncbi.nlm.nih.gov/pubmed/22821065
http://www.ncbi.nlm.nih.gov/pubmed/12208174
http://www.ncbi.nlm.nih.gov/pubmed/8420152
http://www.ncbi.nlm.nih.gov/pubmed/16257505

(see older post "is parkinson's an autoimmune disease?" while this page is under construction)

Mycobacteria and Multiple Sclerosis (with herpes viruses causing the cross-targeting)
 http://www.ncbi.nlm.nih.gov/pubmed/21409957
http://www.ncbi.nlm.nih.gov/pubmed/14616302
also
http://www.ncbi.nlm.nih.gov/pubmed/15150306 and http://rheumatology.oxfordjournals.org/content/39/8/930.full (which I think psoriatic athritis and psoriasis are mycobacterias)

Type 2 diabetes: raised Il-6 caused by inflammation over mycobacteria. Not all type 2 will be this but perhaps a large group where lifestyle doesn't seem to be a factor in the disease.

Asthma or sinus

PANDAS:  Mycobacteria and strep cross-targeting the basal Ganglia

Mycobacterias are gluten sensitive, changing morphology with the presence of gluten so Psoriasis, this form of parkinson's, this form of asthma....they should all be gluten sensitive.

Psoriasis and gluten
http://www.ncbi.nlm.nih.gov/pubmed/8286249
http://www.ncbi.nlm.nih.gov/pubmed/10651693
http://www.ncbi.nlm.nih.gov/pubmed/14690336
http://www.ncbi.nlm.nih.gov/pubmed/8547041
http://www.ncbi.nlm.nih.gov/pubmed/21418272
http://www.ncbi.nlm.nih.gov/pubmed/16436335


Mycobacterias are sensitive to green tea's  EGCG. Caution should be taken with it. Killing off mycobacteria should help the situation but "kill off" my also trigger allergic responses.

THIS PAGE IS STILL UNDER CONSTRUCTION.

Autoimmune Basal Ganglia from 2 infections in: PANDAS, OCD, Tourettes, narcolepsy, & Encephlaitis Lethargica. Cross-targeting autoimmunity

 Hypothesis: The cross-targeting of infections at the same tissue causes autoimmune disease.  One infection marks the outside while another marks the inside...only then does the immune system become confused and attack

Please see newer post: http://angelabiggs.blogspot.com/2015/02/over-view-of-brain-autoimmunity.html

I started to post how my cross-targeting theory applies to PANDAS, Tourettes, OCD and narcolepsy...and then I remembered Encephalitis Lethargica.

Before I start posting suspects and demonstrating the cross-targeting on the Basal Ganglia that I suspect I need to respectfully identify Dr. Andrew Church who works on Encephalitis Lethargia.

Everyone remembers the 1990 Awakenings movie with Robin Williams as Dr. Oliver who in 1918 dealt with an cluster of encephalitis lethargia patients.  In 1993 Dr. Andrew Church found himself with another Encephalitis cluster and he discovered that 2 infections were there not just the flu. Dr. Andrew discovered that a high number of his patients had a rare form of strep called Diplococcus along with the spanish flu.  He has spent a life time trying to piece together this disease.

In 2011 Dr. Andrew came out with this paper proving Encelpalitis lethargia was an autoimmune disease with antibodies directed at the Basal Ganglia. http://brain.oxfordjournals.org/content/127/1/21.full.pdf

Here today I am looking at the autoimmune diseases that cross-target on the Basal Ganglia. In this case the severity of the disease may depend on what mix you had causing the cross-targeting.  My theory supports and validates his research.

Other Basal ganglia autoimmune diseases: http://qjmed.oxfordjournals.org/content/96/3/183.full

The NY cluster of LeRoy High PANDAS cluster.  Dr. Trifiletti has also found 2 infections involved with this autoimmune disease which targets the Basal Ganglia.  He has found Streptococcus pyogenes in 5 of the 8 girls and Mycoplasma pneumonia in 7 of the 8.

Parents of PANDA children have discovered their kids can relapse even after antibiotic recovery when their children receive a flu shot.  I believe this is because the flu shot generates antibodies against the Basal Ganglia.

In England a cluster of children developed Narcolepsy which is a disorder of the basal ganglia after receiving a swine flu shot.  The question is did they have another infection's antibodies there too? What infection broke the brain's blood barrier?
Update 6/29 History of strep was found in Narcolepsy patients
http://med.stanford.edu/psychiatry/narcolepsy/articles/ResponseToMarcusH1n1.pdf  
Antibodies for strep found in narcolepsy patients
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717204/pdf/aasm.32.8.979.pdf

Tourettes has been associated not just with strep but with borrellia burgdorferi (lyme disease). Although  I am about to show a connection with Lyme I think there exists a genetic disposition where only strep is required to develop the autoimmune reaction but this would be the kind of Tourettes that runs in families. (Rheumatic fever which is also an autoimmune reaction to strep has a genetic component and runs in my family....strep alone causes the autoimmune response of the joints etc)
Lyme and Tourettes:
http://www.ncbi.nlm.nih.gov/pubmed/15590039 
http://www.tourette-gesellschaft.de/download/bts_lymedisease_muelleretal.pdf
http://www.ncbi.nlm.nih.gov/pubmed/9482302

Tourettes and lyme (this link added 2016)
http://abcnews.go.com/Health/girl-tics-bucks-doctors-blames-lyme-disease/story?id=19128125
 
My cross-targeting hypothesis is supported when one looks at the Basal Ganglia related autoimmune diseases.  In order for autoimmune disease to develop 2 infections typically exist both causing the immune system to target the same thing.

Encephalitis lethargia: strep and spanish flu virus (H1N1 subtype not seen right now)
Tourettes: strep/ lyme's Borrellia and herpes ?
PANDAS/OCD: strep / mycobacteria and swine flu (common H1N1?)
Parkinson's: mycobacteria and avian flu virus
Cataplexy : strep and swine flu


Looking at this list Strep stands out.  Strep definitely can get through or weaken the Blood Brain Barrier. http://blog.lib.umn.edu/nich0185/myblog/2011/10/the-blood-brain-barrier-and-ocd.html
http://nizetlab.ucsd.edu/publications/iaga-jci.pdf

The borriella of lyme disease drills a hole for itself through the barrier.
http://www.ncbi.nlm.nih.gov/pubmed/22355605

Mycobacteria weave their way through the barrier.
http://www.ncbi.nlm.nih.gov/pubmed/16586367

Once the protective barrier of the brain is down the antibodies seep through.  All of these infections focus the immune system on the Basal Ganglia as a target but the mix you have could determine which disease you have?

Herpes and Tourettes references:
http://www.ncbi.nlm.nih.gov/pubmed/?term=herpes+virus+tourettes 
http://www.ncbi.nlm.nih.gov/pubmed/3195682
http://www.autism.com/ari/newsletter/112/page2.pdf
http://www.ncbi.nlm.nih.gov/pubmed/18378549   (basal ganglia,herpes and movement)

Note that there are multiple types of swine flu and the CDC needs to start tracking which flu is associated with which autoimmune disease. (which swine flu etc since there are different ones)

The idea is: the outside of the nerves are targeted by the first infection then the virus causes the targeting of the inside of the nerve....the cross targeting causes the autoimmune disease.

*this page is under construction and more references and OCD will be discussed soon.

Tics/OCD and strep
http://www.ncbi.nlm.nih.gov/pubmed/11466169
http://www.ncbi.nlm.nih.gov/pubmed/15241433

low levels of histamine, histamine gene, and genetic tourettes
http://www.scientificamerican.com/article/treating-tourettes/



Angela Biggs

Is Chronic Fatigue (myalic encephalomyelitis ) an autoimmune disease?

Hypothesis: An infection first produces an antibody response towards self  but autoimmunity does not develop until a virus infects the target too and causes cross-targeting.  The immune system is attacking self because 2 different infections push the system over the edge and only then does autoimmune disease develop.

In Chronic Fatigue the antibodies are directed toward serotonin and the 5-ht neurons.
http://www.ncbi.nlm.nih.gov/pubmed/23664637

The Borna disease virus is known to infect these neurons in animals which typically results in an induced up regulation of serotonin. I suspect this virus.

 Just found references showing BDV in patients:
http://www.ncbi.nlm.nih.gov/pubmed/9396313
http://www.ncbi.nlm.nih.gov/pubmed/10529109
http://www.ncbi.nlm.nih.gov/pubmed/8839433
http://www.hirou.jp/english/pdf/ikuta.pdf
https://scholars.duke.edu/display/pub703748

As for the initial infection: RA tends to overlap chronic fatigue.  My suspect for that is Mycoplasmas which could also infect nerves and it has been found in some Chronic fatigue patients.
http://www.ncbi.nlm.nih.gov/pubmed/12879275
http://www.ncbi.nlm.nih.gov/pubmed/10691196
http://onlinelibrary.wiley.com/doi/10.1111/j.1574-695X.2002.tb00626.x/abstract
http://www.cfids-cab.org/cfs-inform/Mycoplasma/endresen03.pdf

What could be happening here: the mycoplasmas infect the 5-HT neurons first generating the antibodies to develop then if the person is unlucky enough to then catch the Borna virus which infects these nerves....cross-targeting triggers the autoimmune disease.

Too early to say that this is happening because not enough research has been done. However based on the immune suppression drugs given to patients Chronic Fatigue syndrome does appear to be autoimmune.
http://discovermagazine.com/2013/may/01-are-b-cells-to-blame-for-chronic-fatigue-syndrome#.Ub_AzpwQMs3

Addison's Disease : is it a 3 stage autoimmune disorder?

The autoimmune hypothesis typically is 2 stages:  an infection creates the build up of antibodies through morphology switching  followed by a viral infection which causes cross-targeting triggering the autoimmune disease.

This particular autoimmune disease requires more then the genetic susceptibility to infection followed by cross targeting.  It is known to have the recessive gene AIRE associated with it.  AIRE is an "Auto-Immune-REgulator" gene.

This makes some sense because Addison's disease is not common but the culprits Candida and Hepatitis I am considering are rather common.

Stage one infection Candida
 (some have AIRE gene also)
http://www.ncbi.nlm.nih.gov/pubmed/23000069 
http://www.ncbi.nlm.nih.gov/pubmed/17891543
http://www.ncbi.nlm.nih.gov/pubmed/11978574

Stage two infection Hepatitis
Hepatitis C
http://www.ncbi.nlm.nih.gov/pubmed/22839422
Hepatitis B
http://www.ncbi.nlm.nih.gov/pubmed/22346436

Stage 3  The autoimmune chases the virus to more organs

Hepatitis can spread to multiple organs. Perhaps in Addison's disease the autoimmune trigger started somewhere else, cross-targeting at the pancreas for example causing Type 1 diabetes.  The AIRE gene however makes cross-targeting unnecessary at the later targets....for the adrenal glands all you would need would be the virus.  If this is true then Addison's is never the first autoimmune disease to develop rather it is an echo...of another.  Possible?  

Addison's disease HLA-B8 HLA-DR3
https://www.ncbi.nlm.nih.gov/pubmed/25040682

Salt , autoimmune disease, and viruses

If we say that Cross-targeting must occur for Autoimmune disease to attack then how does salt fit in?


Cross-targeting is where the immune system attacks from Bcells looking for a visable infection like bacteria, fungus or mycoplasma and from a Tcell viral infection inside of cells. Two modes of attack focused on the same target.

Maybe salt increases the likelihood that cells are virus infected in the first place and attacked.   

Salt increases autoimmune disease:
http://www.huffingtonpost.com/2013/03/06/salt-autoimmune-disease-sodium-multiple-sclerosis-diabetes_n_2821200.html

Salt increases the amount of viruses absorbed by cells
http://www.jimmunol.org/content/61/1/65.abstract

Salt effects the immune system's tcells
http://www.ncbi.nlm.nih.gov/pubmed/23467095

Note that while Bcells are suppose to flag targets that are visible with antibodies Tcells go to HLA mailboxes expressed on all cells and check what is inside cells thus Tcells are responsible for finding viruses. 

Does salt increase the activation of HERVs? the old viruses that are are dormant merely buy favoring more virus infections? Further does salt increase the likelihood that t-cells would attack a herv activated cell?

I am just trying to fit this new piece of the puzzle into my current Hypothesis.