Hypotheses: Autoimmune Cross-targeting, Co-carcinogenesis, and Quorum complications

Sunday, September 28, 2014

Cross-targeting autoimmune hypothesis and rheumatic fever?

Friday, September 26, 2014

Are cataracts caused by autoimmunity?

Tuesday, September 23, 2014

Lupus vs. Sjogren can you separate them with transglutaminase?

This board is still under construction

Higher levels of transglutaminase in Sjogren's than in Lupus and RA
http://www.ncbi.nlm.nih.gov/pubmed/21413148

Candida and transglutaminase: the Hypyal wall protein is a substrate for transglutaminase and is involved with the attachment to epithelial walls
http://www.jbc.org/content/279/39/40737.full

the gluten and casein could be triggering dimorphic switching fungal infections (mold to yeast) but which enzyme it would be acting on is unknown but this would be anti-gluten not anti-transglutaminase....but is it lupus or sjogren that has gluten: http://ard.bmj.com/content/63/11/1501.full
sjogren has the gluten sensitivity : http://www.ncbi.nlm.nih.gov/pubmed/17613926
http://www.ncbi.nlm.nih.gov/pubmed/13680146
http://celiacdisease.about.com/od/commoncomplicationsofcd/a/Celiac-Disease-Sjogrens-Syndrome.htm

Lupus and RA have Wibg antibodies???? do mycoplasmas use them???? Later post

If fungal infections are involved with Sjogren's, Hashimoto's, vitiligo, colitis, and asperger's....are all of these associated with higher Transglutaminase antibodies?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604853
which is a vitiligo paper

Found at high levels in both Lupus and sjogren is ROs and correlated with Rheumatoid factor? What is common here between mycoplasmas and fungal infections that would do this?
http://www.ncbi.nlm.nih.gov/pubmed/1603204

RA, stroke, irregular heartbeats, and mycoplasmas?

Looking at patterns of overlap....

RA/lupus and stroke
http://www.ncbi.nlm.nih.gov/pubmed/24898360
http://www.ncbi.nlm.nih.gov/pubmed/22214618

RA/lupus and irregular heart beats (arrhythmias)
http://www.ncbi.nlm.nih.gov/pubmed/24633413
http://www.ncbi.nlm.nih.gov/pubmed/24050965

mycoplasmas and stroke
http://www.ncbi.nlm.nih.gov/pubmed/24223604
http://www.ncbi.nlm.nih.gov/pubmed/21799166

mycoplasmas and irregular heartbeats (arrhythmias)
http://www.ncbi.nlm.nih.gov/pubmed/6179447
http ://www.ncbi.nlm.nih.gov/pubmed/6816867

Thursday, September 18, 2014

juvenile idiopathic arthritis and celiac disease....e.coli?

Hypothesis:
Cross-targeting: the layering of 2 different infections on one target causes autoimmune disease. A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria..etc.. infection marking the outside.

http://www.ncbi.nlm.nih.gov/pubmed/23448357

Celiac aand Juvenile idopathic arthritis
http://www.ncbi.nlm.nih.gov/pubmed/22472933
http://www.ncbi.nlm.nih.gov/pubmed/15695302

e.coli and JIA
http://www.ncbi.nlm.nih.gov/pubmed/17469159

urinary track infection and JIA
http://www.ehealthme.com/cs/juvenile+arthritis/urinary+tract+infection

reactive arthritis and urinary tract infections
http://www.niams.nih.gov/Health_Info/Reactive_Arthritis/

do kids with JIA get Dermatitis Herpetiformis (blistering chronic skin disease)?

celiac and uvetis
http://www.ncbi.nlm.nih.gov/pubmed/22408231
http://link.springer.com/article/10.1007%2Fs00296-009-1177-z#page-1

chronic uveitis (arthritis of the eye) and JIA
http://www.ncbi.nlm.nih.gov/pubmed/16395772
http://www.ncbi.nlm.nih.gov/pubmed/21378109
http://www.ncbi.nlm.nih.gov/pubmed/15693100

virus triggered
http://www.ncbi.nlm.nih.gov/pubmed/22825024

schnitzler syndrome? how rare is this?
http://www.ncbi.nlm.nih.gov/pubmed/23812931
http://www.ncbi.nlm.nih.gov/pubmed/18371052

the adult stiff syndrome and some children with JIA ...not the same thing!!
http://www.ncbi.nlm.nih.gov/pubmed/20676642

Wednesday, September 17, 2014

discord lupus and Vitiligo with autoimmune cross-targeting?

Tuesday, September 16, 2014

Is idopathic thrombocytopenic purpura caused by cross-targeting autoimmunity? H.pylori and zika?

Idopathic thrombocytopenic purpura

Cross-targeting: the layering of 2 different infections on one target causing autoimmune disease. A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria..etc.. infection marking the outside.

In most cases of Idopathic thrombocytopenic purpura, H.pylori marks the outside of the host's platelets.

ITP antibodies to platelets
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538143/

Eradication of H.pyloir has been shown to help or cure ITP

H. pylori
http://www.ncbi.nlm.nih.gov/pubmed/24505529
http://www.ncbi.nlm.nih.gov/pubmed/21120192
http://www.ncbi.nlm.nih.gov/pubmed/15765778
http://www.ncbi.nlm.nih.gov/pubmed/11157503

note that H. pylori replicates inside of bone marrow derived dendritic cells and it would be a small leap to believe that it could eventually infect other bone marrow derived cells like platelets or in infecting these types of marrow cells accidentally triggering antibodies toward platelets

The question I have : do other spirochetes infect the bone marrow? Does syphillis' t. pallidum or lyme's b.burgdorferi or the dog spirochete leptospira???

However other infections can cause ITP...the key is that they generate antibodies against platelets. Here are examples of mycoplasmas: http://www.ncbi.nlm.nih.gov/pubmed/19474700
http://www.ncbi.nlm.nih.gov/pubmed/19474700
(the mycoplasma cases would have RA)

More than one virus may be able to cause the necessary cross-targeting on platelets but they must somehow infect or generate antibodies against platelets:

Flaviviruses infect bone marrow and should trigger it
dengue and ITP
http://www.ncbi.nlm.nih.gov/pubmed/24879007
http://www.ncbi.nlm.nih.gov/pubmed/26434084
http://www.ncbi.nlm.nih.gov/pubmed/25728040

Added 4/30/1016 : Zika and ITP
http://www.theguardian.com/world/2016/apr/30/zika-virus-symptoms-american-death-puerto-rico-risks

Hepatitis C and ITP
http://www.ncbi.nlm.nih.gov/pubmed/24457056
http://cid.oxfordjournals.org/content/39/6/790.full

Hepatitis C infecting the bone marrow (which would include platelet cells)
http://www.ncbi.nlm.nih.gov/pubmed/21188328

influenza A and ITP
http://www.ncbi.nlm.nih.gov/pubmed/15614463
http://www.ncbi.nlm.nih.gov/pubmed/21962253

Influenza A absorbed by platelets
http://www.bloodjournal.org/content/28/2/213?sso-checked=true

Note that there is a strong overlap with Primary biliary cirrhosis (an autoimmune disease of the liver) and ITP
http://www.ncbi.nlm.nih.gov/pubmed/9185750 which makes sense because some of these infections are known to infect liver cells in addition to the fact that the liver filters the blood.