Tuesday, May 19, 2020

Is Kawasaki disease an autoimmune disease caused by the cross-targeting of two infections?

Autoimmune cross-targeting hypothesis: Two infections on one target tissue. One infection involves infecting inside of cells the other outside of the cells of the target tissue.

Kawasaki as an autoimmune disease
https://pubmed.ncbi.nlm.nih.gov/25882057/?from_term=kawasaki+disease+autoimmune&from_pos=9

https://pubmed.ncbi.nlm.nih.gov/31013925/?from_term=kawasaki+disease+autoimmune&from_pos=2

The inner viral infections:

Viruses associated with Kawasaki disease : enterovirus adenovirus rhinovirus and coronavirus
https://www.sciencedirect.com/science/article/pii/S0929664614000035

coronavirus
https://pubmed.ncbi.nlm.nih.gov/15655771/?from_term=kawasaki+coronavirus&from_pos=1

The outer bacterial infections:

Strep and Kawasaki
https://www.npjournal.org/article/S1555-4155(12)00621-6/pdf

Location is more important than the type of virus when triggering autoimmune disease. If an infections exists inside of a cell as well as outside then an autoimmune response is triggered.

Coronavirus infection increases the binding of bacterial infections
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168281/

Naphthalene/shampoo from carpet cleaning could trigger Kawasaki how? which infection does it replace ?
https://pubmed.ncbi.nlm.nih.gov/6125730/
https://pubmed.ncbi.nlm.nih.gov/2020511/

naphthalene and ER stress
https://www.dovepress.com/67-dihydroxy-2-4prime-hydroxyphenylnaphthalene-induces-hct116-cell-apo-peer-reviewed-article-DDDT
napthalene and ER damage
https://www.sciencedirect.com/science/article/abs/pii/0022201185901090

Covid-19 and multisystem inflammatory syndrome
https://www.nejm.org/doi/full/10.1056/NEJMoa2021680
https://www.statnews.com/2020/06/29/nejm-inflammation-children-covid19-misc/