Is Pemphigus foliaceus an autoimmune disease caused by cross-targeting? Do 2 infections trigger disease?

Cross-targeting:  the layering of 2 different infections on one target causing autoimmune disease.  A viral infection marking the inside. A larger infection marking the outside.

Does Pemphigus foliaceus have 2 associated infections?

Herpes virus and Pemphigus foliaceus
http://www.ncbi.nlm.nih.gov/pubmed/19822095
http://www.ncbi.nlm.nih.gov/pubmed/21038546
http://www.ncbi.nlm.nih.gov/pubmed/10606848
http://www.ncbi.nlm.nih.gov/pubmed/21537760


Mycobacterias and  Pemphigus foliaceus
(psoriasis might be mycobacteria caused)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276776
leprosy and Pemphigus
http://www.ncbi.nlm.nih.gov/pubmed/1897831

Mycobacterium chelonae?
http://www.ncbi.nlm.nih.gov/pubmed/16405612

Autoimmune cross-reactivity versus cross-targeting: what is the difference?

Autoimmune cross-reactivity versus cross-targeting: what is the difference?

Think of antibodies as flags the immune system marks an infection with. The antibody flags are only suppose to stick/bind to a sequence of the infection.

Cross reactivity is when an antibody binds not just the antigen(sequence) of the infection but an antigen of self because the protein is either the same or similar enough.  Our own body has accidentally become labeled with infection flags.

Even with the mislabeling our body's immune system is usually intelligent enough not to attack self.

This is where cross targeting comes in.  Cross targeting is when 2 infections have made the immune system focus on one organ.  Antibodies have mislabeled or both infections infect the target.  For the immune system to attack self and turn into autoimmune disease it is my theory that a viral infection has to mark it for t-cells and an outer infection for B-cells has to mark it. 

For example:  Anti-insulin from E.coli could mark the outside of the pancreas through cross reactivity.  Then the person develops the flu which replicates in our pancreas....the virus marking the inside of the pancreas cells.

The layering of infections causes cross-targeting of the immune system to attack from 2 levels and results in type one diabetes where our immune system would attack our pancreas.

Does this make sense?
I hope I am getting better at explaining this.
Angela Biggs