Type 1 diabetes caused by cross-targeting autoimmunity?

Type one diabetes appears to have multiple infections that fit the profile but the common theme will be that the cross-targeting occurs at the pancreas.

Infection culprits:
Celiac disease can be linked to the dimorphic E. coli. http://www.ncbi.nlm.nih.gov/pubmed/8660085 Celiac disease has been linked to type one diabetes.

 Candida has also been linked to type one diabetes. Candida is also dimorphic shifting between a yeast and mold form.

Aspergillus has also been linked to type 1 diabetes. http://www.ncbi.nlm.nih.gov/pubmed/23625788

These infections have insulin related materials that could produce the anti-insulin antibodies that are seen in the precursor stage of Type 1 diabetes
http://www.ncbi.nlm.nih.gov/pubmed/3933801 

In the case of RA and type 1 diabetes: mycoplasmas infect cells including the pancreas.  anti-insulin antiboides do not even have to develop in this case. If the mycoplasmas infect the pancreatic cells and then a virus does....cross targeting can occur.   


Viral infection culprits:
Coxsackie causes the pancreas to be a focus
http://www.bioscience.org/1997/v2/e/ramsingh/ramsingh.pdf

The flu virus incubates, replicates and causes the pancreas to be a focus
http://www.ncbi.nlm.nih.gov/pubmed/23097451

Behcet's Disease is it a cross-targeting autoimmune disease?

The autoimmune hypothesis pattern: an infection first inducing antibodies followed by a viral infection which causes cross-targeting thus triggering the immune system to attack causing autoimmune disease.

For Behcet's disease the infection culprits are Streptococcus sanguinis and herpes simplex (mouth ulcers)

http://www.ncbi.nlm.nih.gov/pubmed/23137016
http://www.ncbi.nlm.nih.gov/pubmed/18693149
http://www.ncbi.nlm.nih.gov/pubmed/21052488
http://www.ncbi.nlm.nih.gov/pubmed/22204815
http://www.ncbi.nlm.nih.gov/pubmed/22766172


I found a strange overlap with MS and Behcet's.
http://www.ncbi.nlm.nih.gov/pubmed/12645628

For MS I have as psoriasis or eczema with herpes zoster triggering the autoimmune disease.   

Could this be an entirely different type of MS? Where the strep has opened the blood brain barrier and the herpes virus is there?  Is this actually a form of Alzheimer's?   Where the herpes simplex virus is destroying the mitochondria?  Or do I need to become much more specific with the herpes viruses? That could be the case. 

Balo was/is a different type of MS where the virus is a hepatitis C virus and causing the ring shaped lesions. Balo is really a distinct autoimmune disease from MS. 

alopecia areata is it caused by autoimmune cross-targeting?

So the pattern for my autoimmune hypothesis is an infection that generates antibodies first by changing what it looks like. (pigment or morphology) Then a viral infection generates antibodies that induces cross-targeting.  Antibodies from 2 different types of infections induces the autoimmune disease.

Alopeica aterata is an autoimmune hair loss from a follicle on skin. Thus the cross-targeting must focus on the skin.  

Any infection of the skin could if more then one morphology or pigment was produced stimulating the immune system.

 http://www.ncbi.nlm.nih.gov/pubmed/7742246
http://www.ncbi.nlm.nih.gov/pubmed/23700152


 vitiligo:  fungal
Rheumatoid arthritis: mycoplasmas

in some cases alopecia overlaps RA and diabetes where i have already suspected Mycoplasmas but i have not found a reference of direct connection between mycoplasmas and alopecia yet but i have them infecting the scalp
http://www.ncbi.nlm.nih.gov/pubmed/12506953 
http://www.ncbi.nlm.nih.gov/pubmed/6657503

 Alternaria chlamydospora.
http://www.ncbi.nlm.nih.gov/pubmed/23329992

A toxin could replace the skin infection because it still draws the immune system to the skin
ant bite
http://www.ncbi.nlm.nih.gov/pubmed/15347501


Any viral skin infection could cause the cross-targeting but one really seems to stand out is Herpes.

The virus that seems to come up the most:
Herpes zoster
http://www.sciencedirect.com/science/article/pii/S0190962208002090
http://www.ncbi.nlm.nih.gov/pubmed/23526118
http://www.ncbi.nlm.nih.gov/pubmed/22838088
http://www.ncbi.nlm.nih.gov/pubmed/23181541
Personal story:http://www.alopeciaworld.com/forum/topics/alopecia-areata-episodes

This is an unproven hypothesis but alopecia areata fits the pattern I am testing on autoimmune diseases with. An infection generating antibodies followed by a virus causing cross-targeting. 

2016 update...we need to sort throught the HLAs
HLA-C alopecia
http://link.springer.com/article/10.1007/s00251-013-0703-z

HLA-C is the Tcell mailbox for the endoplasmic recticulum

The viruses that are known to infect the ER : polyomaviruses like jc and BK
https://www.ncbi.nlm.nih.gov/pubmed/20373089

alopecia and
http://www.jidsponline.org/article/S1087-0024(15)30280-X/pdf

Aspergillus as a suspect

There are so many types of aspergillus.

Aspergillus niger I have connected to bulbs: garlic, onions, and tiger lilies.

Aspergillus flavus I have connected to grains and legumes. (not the anaphylatic peanut allergy that is always eczema and staph)

Aspergillus fumigates is found primarily in compost piles where it decomposes grass and grains. (are these responsible for Hayfever?)

But there are so many of these and they do overlap.

My original notion that we could use our allergies to divide these up may not work as easily as I thought.
I still want to believe that as decomposers they have their specialties or favorites. That they would carve out their niche.

If parasitic things are made to search for their targets do they cause our allergies?

Should we just focus on aspergillus as an infectious group even if the autoimmune diseases they may condition the immune system for could be different? 

Some days things are more confusing then they are clear.
I hope things make more sense tomorrow.
Angela Biggs

Is Churg Strauss disease an autoimmune vasculitis caused by cross-targeting?

Churg Strauss Autoimmune Vasculitis 

Autoimmune theory pattern: an infection first builds up antibodies followed by a viral infection/vaccine which causes cross-targeting thus triggering the autoimmune disease. 

Cross-targeting of the immune system triggers autoimmunity by layering immune system attacks onto one target.  One viral marking the inside of the target and one visible marking the outside of the target...like a fungus or bacteria.

 For Churg-Strauss it might be an Aspergillus infection followed by hepatitis B.

Aspergillus and Churg-strauss connections:
http://www.ncbi.nlm.nih.gov/pubmed/3195817
http://www.ncbi.nlm.nih.gov/pubmed/11141396
Acta clin Croat 2002; 41:95-98  
http://www.ncbi.nlm.nih.gov/pubmed/12456338

Eosinophili pneumonia and Aspergillus:
http://www.ncbi.nlm.nih.gov/pubmed/4209914

Chronic Eosinophilic pneumonia followed by Churg-strauss
http://www.ncbi.nlm.nih.gov/pubmed/8050532 
http://www.ncbi.nlm.nih.gov/pubmed/8938874
  
There seems to be quite an overlap between aspergillus and churg-strauss. I am suggesting that this infection exists first and builds up a state of antibodies.

Then the viral trigger appears in the system and causes cross-targeting.  Producing antibodies that aim at the same target as the earlier infection.

Hepatitis B existing infection and Churg strauss
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845776

Hepatitis B  vaccine and Churg Strauss
http://www.ncbi.nlm.nih.gov/pubmed/11791655
http://www.ncbi.nlm.nih.gov/pubmed/9709187

Both hepatitis B and aspergillus are bloodstream infections which is where the immune system cross targets in Churg Strauss.  Churg-strauss is an immune attack of the vascular system. 

  Churg strauss has also been associated with several years of asthma but only in some patients. This could be due to hot tub asthma or aspergillus in the lungs. (the state of heightened antibodies before the development of the autoimmune disease)
http://www.sepeap.org/archivos/pdf/10226.pdf

Aspergillus seems to like not just vascular and lung walls but intestinal walls. It has been found intestinal tracts too. http://medind.nic.in/ibv/t07/i5/ibvt07i5p375.pdf

Remember it is not aspergillus that causes Chaus-strauss or hepatitis B that causes Chaus-strauss rather the our own immune system after the cross-targeting of these infections to the same location.

The overlap of churg-strauss and polyneuropathy could be the fact that aspergillus makes aflatoxin and aflatoxin can damage the nerves
http://www.elsevier.es/en-revista-neurologia-495-articulo-peripheral-polyneuropathy-and-churgstrauss-syndrome-90304325
http://www.ncbi.nlm.nih.gov/pubmed/25695917
http://www.ncbi.nlm.nih.gov/pubmed/24797730
http://www.ncbi.nlm.nih.gov/pubmed/24626013
http://www.ncbi.nlm.nih.gov/pubmed/24170259

does aflatoxin cause nerve damage?

Foot drop and churg-strauss?
http://www.pcp.org.ph/files/PJIM%20Vol53%20No2/A_Case_Report_of_Churg-Strauss_Syndrome_Presenting_with_Foot_Drop.pdf
http://www.cssassociation.org/patient-stories-reader/items/im-not-drunk-its-churg-strauss-syndrome.html
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088945/

vitiligo and churg-strauss?


This is just a hypothesis and something to be further investigated.
Angela Biggs 

Added for interest:
titanium overcomes the UV light inhibition of the growth of aspergillus 
http://www.ncbi.nlm.nih.gov/pubmed/19579656

Note that aspergillus is a fungus that grows on bulbs and I am looking into allergies to bulb like plants in association to autoimmune vasculitis.  Allergies under consideration: onions, garlic, and  lilies. 

Is it Eales disease is when it involves the eye and overlaps with Hashimoto's and other autoimmune diseases?
https://www.ncbi.nlm.nih.gov/pubmed/20075970

Note that candida and cryptococcus which are also fungal infections I have linked to Hashimoto's thyroid disease on other posts.






 

parkinson's disease is it autoimmune?

The autoimmune hypothesis : antibodies cross-target  from 2 different infections and only then does autoimmune disease develop.

 An infection, in this case mycobacterias, causes a build up of antibodies against dopamine nerves and then a virus infects the same target, these dopamine nerves, thus cross-targeting and giving another reason for the immune system to attack self causing the person to develop the autoimmune disease.

The genetic susceptibility of parkinson's overlaps leprosy.
http://news.sciencemag.org/sciencenow/2004/01/27-01.html

Parkinson's and Nocardia mycobacteria
http://drbroxmeyer.netfirms.com/parkinsons.pdf

For Parkinson's I have been looking at the overlap of il-6 and mycobacterias. The il-6 overlap occurs with type 2 diabetes, psoriasis, and parkinson's. Mycobacterias could be involved with all of these diseases.

 While psoriasis and type 2 diabetes may be due to inflammation from infection and not an autoimmune disease because no viral trigger exists....Parkinson's disease appears to have a viral trigger.  Thus parkinson's might be  autoimmune because it fits the 2 stages.

NOTE: added 9/3 Psoriasis has now been linked to Parkinson's disease. Which makes sense if they are both mycobacteria diseases. http://www.dermatologyupdate.com.au/latest-news/psoriasis-and-parkinson-s-linked


Mycobacterias which are gluten sensitive create antibodies through dimorphic switching maybe priming the immune system. Dimorphic switching means that the infection changes morphology shape.  (E.coli changes morphology when casein triggers the lon enzyme...and enzyme that also exist in mycobacterias)
http://www.ncbi.nlm.nih.gov/pubmed/9425059

As the mycobaterias change back and forth the immune system is generating antibody flags looking for them and one of these antibodies....should predictable be for the dopamine nerves. Unless even easier...the mycobacteria infect these nerves specifically. 

The suspect already under consideration for Parkinson's is the bird flu.
The bird flu virus infects the dopamine nerves triggering the cross targeting. H5NI  is the bird flu (all Influenza A are associated with aquatic birds but not all are referred to as the bird flu) The location of infection triggers the cross-targeting and the immune system develops into autoimmunity.

http://www.parkinson.org/NationalParkinsonFoundation/files/6d/6dea0022-01a5-4d55-926c-42efa0084c18.pdf
http://www.ncbi.nlm.nih.gov/pubmed/19667183 

Now we just have to link, or find the antibodies, or at least be able to explain how antibodies from a mycobacteria would target the Dopamine nerves specifically. This is the closest i have so far and it is probably not the same mycobacteria we are dealing with.

Leprosy, antigens, and periphery nerves
http://www.ncbi.nlm.nih.gov/pubmed/6416726

Maybe Parkinson's is not just an inflammation issue but can be an autoimmune one? My autoimmune hypothesis pattern is an infection first followed by a viral cross-targeting. If mycobacterias start the situation is Parkinson's disease gluten sensitive? or just some of the parkinsonisms?

Here's an example of one parkinson's patient that after antibiotics recovered? Does this mean if you catch it early enough or are only some this type? Was he gluten sensitive ? Not celiac but still gluten sensitive.
 http://www.newscientist.com/article/mg20927962.600-faecal-transplant-eases-symptoms-of-parkinsons.html


I have failed to find a scientific study or journal connecting the two but i did find this article indicating the worsening of Parkinson's with gluten related diseases.
http://www.livestrong.com/article/549400-gluten-sensitivity-parkinsons-disease/

I found that the rare Multiple system atropy kind is gluten sensitive but this is considered a parkinsonism.
http://www.ncbi.nlm.nih.gov/pubmed/?term=gluten+parkinson

Decent list of the types of parkinson's diseases:
 http://www.parkinson.org/Parkinson-s-Disease/Diagnosis/What-are-the-different-types-of-atypical-Parkinson


The genetics of parkinson's infers autoimmune and infectious origin.
https://www.aarda.org/research_display.php?ID=89
 

I wish I had more information about the Parkinson's disease clusters and which group they are in. Anyone out there have this information? I did see a video clip where micheal j. fox was talking about taking the medication intended for the bird flu virus and getting relief. what does that mean? is the virus still active and continuously triggering the immune system?

Which brings me to the children in England which developed narcoplesy after getting a flu shot vaccine. Parkinson's overlaps sleep disorders. Are these kids symptoms related? Different because it was the swine flu H1N1 triggering the autoimmune reaction verse the bird flu H5N1?

Note that the H1N1 swine flu (H1N2 is also considered a swine flu) Has also been associated with nerve infection and inflammation by the virus. http://www.ncbi.nlm.nih.gov/pubmed/21744080

The flu has also been suspected in Parkinson's.
http://www.ncbi.nlm.nih.gov/pubmed/22361110 
http://www.ncbi.nlm.nih.gov/pubmed/22753266

Flaviviruses and parkinson's (update april 2016) viruses like west nile
http://www.ncbi.nlm.nih.gov/pubmed/12935837
http://www.ncbi.nlm.nih.gov/pubmed/26719256
http://www.ncbi.nlm.nih.gov/pubmed/18760350
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779909/ (antiparkinson's drugs)

HLA-DR and parkinson's (cytosol mailbox for RNA virus) (this HLA part added 10/6/2016)
https://www.ncbi.nlm.nih.gov/pubmed/22807207 DRB1
https://www.ncbi.nlm.nih.gov/pubmed/25319953 DRA


I think where these viruses incubate in the body will be key to unraveling autoimmune diseases. Obviously some have more then one incubation area but because of the overlap with other tick disorders the focus seems to be the Basal Ganglia. (see the newer post on autoimmune diseases of the Basal Ganglia)

I would love to figure out which parkinson's diseases are autoimmune and might be connected to the mycobacterias and viruses.  I have been assuming the most common type. Can anyone out there follow my logic?

Remember these are just ideas and unproven theories. I just hope they lead somewhere (please look at the psoriasis post too because it is connected to this one by mycobacterias)
Angela Biggs

Psoriasis is it an autoimmune disease?

Psoriasis as an autoimmune disease.


My autoimmune hypothesis is that a dimorphic infection builds up antibodies and then a virus pushes it into an autoimmune disease.

Psoriasis has the gluten sensitivity which makes me look for a dimorphic infection.  what i found was not fungal or bacterial rather mycobacterias.  Tuberculosis has been associated with psoriasis.

Mycobacteria cause macrophages to produce extremely high levels of il-6.
J. immunol 1997 jan 1; 158(1):330-7
www.jimmunol.org/content/158/1.toc

which is interesting because high levels of il-6 impairs insulin signalling and could cause insulin resistance.
 Vitam Horm 2009; 80; 613-33
http://www.ncbi.nlm.nih.gov/pubmed/19251052

Psoriasis has a high incidence of type 2 diabetes with it not the autoimmune type 1 diabetes.

Psoriasis is associated with an increased risk of Parkinson's. Parkinson's in general has been associated with type 2 diabetes too.
http://www.dermatologyupdate.com.au/latest-news/psoriasis-and-parkinson-s-linked

Type 2 diabetes has been linked to asthma and obesity.

I don't see an "autoimmune cross-targeting attack" here but rather an inflammation that may be gluten sensitive which might indicate the culprit as mycobacterias.

Interestingly we know that EGCG in green tea inhibits the proliferation of mycobacterias...and the matcha form of green tea has the highest concentration.  Could we halt the asthma and help the type 2 diabetes by simply drinking this strong green tea?  Could it help gout and parkinsonisms?

Psoriasis has been shown to coexist with gout, psoriatic arthritis.  Do these people tend to have asthma and type 2 diabetes?

Could gluten elimination help these associated diseases too? Obviously not all asthmas will be gluten sensitive (the eczema associated type would be milk and egg not wheat since it might be staph infection linked) Could a gluten free diet help those who were struggling with type 2 diabetes  not just celiac disease? Even more hopeful...could elimination of the mycobacteria remove the diseases completely? Inflammation should not linger like antibodies do.

What do people think? Could it be that Psoriasis not an autoimmune disease but an inflammation driven one?

Still thinking,
Angela Biggs

Added thoughts: Gluten ataxia is the most common cause of sporadic idopathic ataxia.
Brain 2003 mar 126(pt3):685-91   Are the people who have the psoriasis that develop the parkinson's the same people that would have this form of gluten ataxia? since psoriasis is gluten sensitive?

Are all Parkinson's cases gluten sensitive because the group that appears to have vitiligo might be different.....right? Some Vitiligo has been associated with gluten so are these just different mycobacterias?

I am going to have to research how the types of parkinson's differ next.

In looking at Parkinson's I have found that they also have elevated il-6 thus strengthening the possible link to mycobacterias il-6 rise. 
http://www.ncbi.nlm.nih.gov/pubmed/19857551
http://www.ncbi.nlm.nih.gov/pubmed/19214748

WOW...so here is a connection between il-6 and mitochondrial fragmentation or morphology.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746985/

Just for background for those who have not read all of my posts, under the alzheimer post I made this statement:

" Parkinson's has currently been viewed as a mitochondria disease in that PURL has been indicated.  Purl is a rhomboid protease involved in the morphology of mitochondria.  This would not stop the functioning of the mitochondria rather make transport of them down the axon more difficult.  Purl might be breaking a large mitochondria suv into smaller mitochondria coopers....so to speak...thus a sporatic energy supply.  I don't know if any one has looked into that but it makes me wonder.  If Resveratrol is now said to induce mitochondria biogenesis and has been shown to extend the lifespan of yeast and flies....could it counter the problem in Parkinson's somewhat?"

Okay so i have made a small tangent from types of parkinson's to the mechanism of parkinson's but maybe there are overlaps with this purl and the il-6? both causing smaller mitochondrias?

I hope some one out there reads these posts and can make some connections.
Angela Biggs

Added April 14 2016: Autoimmune cross-targeting hypothesis is the simultaneous infections of 2 infections one on the inside and one on the outside: mycobacterias and HPV in the case of psoriasis
http://angelabiggs.blogspot.com/2016/01/psoriasis-hpv-mycoplasms-and-autoimmune.html 

Does the location of the bacteria decide which autoimmune disease develops in some cases? (autism, MS, and guillain barre)

So the hypothesis is: an infection builds up antibodies and then a virus triggers cross-targeting where the immune system then attacks. 

I am not sure what I am looking at tonight when I am looking at these nerve autoimmune diseases.

Autoimmune diseases with myelin protein antibodies:

schizophrenia correction...yes (https://www.ncbi.nlm.nih.gov/pubmed/2416737)
guillian barre syndrome yes
multiple sclerosis yes
autism yes

Autoimmune disease with measles or herpes?

schizophrenia yes
guillian barre syndrome yes
multiple sclerosis yes
autism yes for measles and herpes encephalitis (maybe zoster?)

Does measles or the herpes virus cause myelin protein antibodies?  I could not find a listing of the specific neural antibodies known to be generated by the measles vaccine.

If the same viruses are present for all 3 of these diseases does the bacteria infection make them different disease?

Guillain barre the suspect is Campylobacteria Jejuni. This infection begins in the gut but triggers the autoimmune paralysis of the legs...the peripheral nervous system.

references of Guillain barre and campylobacteria
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC128258
http://www.ncbi.nlm.nih.gov/pubmed/23514735
http://www.ncbi.nlm.nih.gov/pubmed/23528202

Multiple sclerosis my suspect is staph because of the association with eczema.  Staph is known to infect the central nervous system. Multiple sclerosis is a disease of the CNS.


In Autism the suspect is sutterella  which is known to be found in both the gut and brain abscesses. It seems possible that an infection that likes to live with our brain cells would try to look like a brain cell.  Autistic mother's who generate antibodies to the brain...do they have sutterella too like some of the autistic kids?
Sutterella and Autism ref
http://www.ncbi.nlm.nih.gov/pubmed/22233678

I wish we had more antibody data to look at.

Anyone out there think this is possible?
Hopeful,
Angela Biggs

Please note that the swine flu which can also infect the nerves has also been associated with guillain-barre. http://www.ncbi.nlm.nih.gov/pubmed/21744080

This is a cross-targeting issue of the immune not really an infection specific issue.

For Multiple sclerosis Herv-k which appears to be a central nervous system retrovirus could replace the measles or herpes as triggering the cross-targeting.   (added 5/28)