Sunday, June 26, 2016

Precancerous signs of herpes viruses and HPV ? (before carcinogen turns it into cancer) but I am suspicious

Are herpes viruses the cause of cysts? ovarian or breast cysts?

Ovarian cysts are a risk for ovarian cancer
http://www.aafp.org/afp/2009/0915/p609.html

Herpes virus mRNA and ovarian cancer
http://www.ncbi.nlm.nih.gov/pubmed/25485872

Breast cysts risk for breast cancer of Estrogen receptor type? In cows they do
http://www.ncbi.nlm.nih.gov/pubmed/17491080

(herpes viruses maybe using estrogen receptors to infect cells)

Breast cancer has antibodies to cyst liquid
http://www.ncbi.nlm.nih.gov/pubmed/6286196

Think of a herpes simplex blister...a fluid filled bubble. sort of sounds like a cyst

Some forms of prostate cancer have been linked to Epstein barr (herpes virus).

Forms of prostate cysts have been identified.
http://pubs.rsna.org/doi/pdf/10.1148/radiographics.10.4.1696019
And some cancers have been linked with the cysts (relationship unclear)
http://www.ncbi.nlm.nih.gov/pubmed/11692605
http://www.jultrasoundmed.org/content/suppl/2015/02/27/15.1.75.DC1/15.01.75.pdf

Simple kidney cysts, kidney cancers and EBV

several viruses are connected to kidney cancer (renal cancer): Epstein barr is one
http://www.ncbi.nlm.nih.gov/pubmed/22237219

acquired cysts and renal cancer
https://www.researchgate.net/publication/276091919_Acquired_cystic_disease_and_renal_cell_carcinoma_in_hemodialysis_patients_A_case_report_on_three_patients

Looking at epstein barr and fibroadenomas....EPV was not really statistically connected to Fibroadenomas
http://scialert.net/fulltext/?doi=ajbs.2012.365.371

Are HPVs the cause of abnormal cell growth at the breast and in the cervix? 

Fibroadenoma are benign precancerous tumors of the breast and may increase the risk of breast cancer
http://www.nejm.org/doi/full/10.1056/NEJM199407073310103#t=article

Fibroadenoma has been connected to DNA type viruses
http://link.springer.com/article/10.1007%2FBF00799807#page-1

collecting references and still working on the thoughts below:

Cervical dysplasia are the abnormal cells of the cervix which have been connect to HPV which are considered a risk factor for cervical cancer (abnormal pap smear)

If HPV uses the cannabinoid receptors are these the cancers that have favorable responses to cannabis? could the irregular cells cannabinoid sensitive?

In skin cancer (non melanoma type) they have noticed a difference with cannabis...and warts are known to be indicators of skin HPV infections.

In men:

Testicular cancer and HPV
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527817/

Note that irregular sperm has been connected to an increased risk of testicular cancer (the abnormal cells)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1118599/
http://www.ncbi.nlm.nih.gov/pubmed/16217294

Head and neck cancers could be HPV and alcohol (carcinogen)....are there visible irregular cells here first?










Friday, June 24, 2016

Thursday, June 23, 2016

Toxic epidermal necrolysis (TEN), also known as Lyell's syndrome and autoimmune cross-targeting

Autoimmune cross-targeting hypothesis suggests that simultaneous infections on one target triggers autoimmunity.  One infection on the outside of the target cell and one infection, like a virus, on the inside of the target.  

Lyell's syndrome is the acute onset of scalding skin triggered by a new medication
http://www.ncbi.nlm.nih.gov/pubmed/19766401

pemphigoid after lyell's syndrome
http://www.sciencedirect.com/science/article/pii/S0161642011008955

Main trigger is sulfa drugs. Sulfonamide antibiotics inhibit a bacteria's ability to make folic acid/dihydrofolic which are needed to make DNA.

People get their folic acid from their diet. (sulfa drug do not inhibit our DNA production)

Having said that it is not harmful for DNA production :

There could be a big difference between the organic MSM sulfur our body uses normally and the drug forms of sulfur.  Although our DNA production may not be an issue it could be that the drug forms of sulfur when "used by our cells" are actually viewed by our body's immune system as foreign.

Sulfa is used in our muscle and skin cells.

So in the autoimmune cross-targeting hypothesis this sulfa drug replaces the virus as foreign. It is unclear right now what infection would mark the outside.  It could be any skin infection: fungal, mycobacterial, staph, or mycoplasmas.


Goodpastures disease reexamined as autoimmune cross-targeting of fungal infections and the flu

Goodpasture's: autoimmune cross-targeting on the kidney?

Autoimmune cross-targeting hypothesis suggests that simultaneous infections on one target triggers autoimmunity.  One infection on the outside of the target cell and one infection, like a virus, on the inside of the target.  

Goodpasture's and type one diabetes: (fungal or mycoplasmas or e.coli/campylobacterias???)
http://ndt.oxfordjournals.org/content/14/8/1997.full

Flu virus and goodpasture's have been connected for years
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2378623/?page=1

Flu virus that infects the kidney is rare in the united states because H7N9 is rare? Is it possible it is this flu virus? or the rare case that the other flu viruses use the D5 receptor?

H7N9 flu and D5

D5 is on the kidney

H7N9 and kidney issues
http://www.ncbi.nlm.nih.gov/pubmed/23992125
http://www.ncbi.nlm.nih.gov/pubmed/25579740
https://100dialysis.wordpress.com/2013/05/24/h7n9-kills-and-attacks-kidneys/

this flu can also trigger type one diabetes
http://jvi.asm.org/content/87/1/597.full

Does the areas of china with this H7N9 have increased Goodpastures?

 previous goodpastures blog post
http://angelabiggs.blogspot.com/2014/04/autoimmune-cross-targeting-in-good.html

Linked the spanish flu and Goodpastures
http://doctorrw.blogspot.com/2006/01/goodpasture-syndrome-and-spanish-flu.html

Kidney and fluA
http://www.ncbi.nlm.nih.gov/pubmed/984071 
http://www.ncbi.nlm.nih.gov/pubmed/12698331

Which infections cross-target with this flu in the kidney?

Fungal infections and the kidney
http://medind.nic.in/iav/t01/i4/iavt01i4p147.pdf

goodpastures has been connected to lupus or wegeners
https://www.kidney.org/atoz/content/goodpasture

Several infections are connected to wegeners: aspergillus
http://angelabiggs.blogspot.com/2016/05/is-wegeners-granulomatosis-caused-by.html

goodpastures and aspergillus
http://www.sciencedirect.com/science/article/pii/S2211753913000390

antigen in goodpastures, cutaneous lupus erythematosus, pemphigoid, and lichen planus
http://www.ncbi.nlm.nih.gov/pubmed/11007769

Lichen planus I had linked to the fungus trichophyton
http://angelabiggs.blogspot.com/2016/05/is-lichen-planus-autoimmune-cross.html

lupus has been linked to fungal infections

discord lupus and trichophyton
http://angelabiggs.blogspot.com/2014/09/discord-lupus-and-vitiligo-with.html






Pemphigoid and autoimmune cross-targeting

Autoimmune cross-targeting hypothesis suggests that simultaneous infections on one target triggers autoimmunity.  One infection on the outside of the target cell and one infection, like a virus, on the inside of the target.  

Pemphigoid: cox-2 inhibitiors and mycobacteria/fungal infections

Pemphigoid is an autoimmune skin blistering disease of the elderly
https://en.wikipedia.org/wiki/Pemphigoid

linked to psoriasis which is mycobacteria
http://www.ncbi.nlm.nih.gov/pubmed/17076725

UV light triggered pemphigoid in fungal skin infections
http://www.ncbi.nlm.nih.gov/pubmed/2225541
http://www.ncbi.nlm.nih.gov/pubmed/3888880

This could be similar to steven-johnson's where the cox-2 inhibitors like acetaminaphen are triggering cross-targeting when the skin cells exposed to UV causing cox-2 expression....but with these infections mycobacteria or fungal the blistering is less severe?

Steven-johnson's disease
http://angelabiggs.blogspot.com/2016/06/is-steven-johnsons-cross-targeting-of.html

Which is interesting to further consider scalded skin syndrome which is said to be staph producing a toxin which damages the skin.  Is scalded skin syndrome autoimmune cross-targeting too?










Sunday, June 19, 2016

Is Steven-johnson's the cross-targeting of cox-2 inhibitors and mycoplasmas at the skin?

Autoimmune cross-targeting hypothesis suggests that simultaneous infections on one target triggers autoimmunity.  One infection on the outside of the target cell and one infection, like a virus, on the inside of the target.  

Previous I had looked at RA as autoimmune cross-targeting of mycoplasmas and epstein barr virus
http://angelabiggs.blogspot.com/2015/08/rheumatoid-arthritis-as-autoimmune.html

tumeric and arthritis..which encourages people to take against mycoplasmas
http://onlinelibrary.wiley.com/doi/10.1002/art.22180/abstract

curcumin is active against a lot of bacterias
http://www.hindawi.com/journals/bmri/2014/186864/
but is it active against the mycoplasmas of RA

However this blog suggests there is a risk to taking tumeric/curcumin against mycoplasmas

curcumin and steven-johnson's syndrome
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650986/

curcumin does more than kill bacteria it inhibits cox-2: it's anti-inflammation ability
http://curcumin-turmeric.net/inflammation.html

steven-johnson's is an autoimmune skin blistering disease...severe
https://en.wikipedia.org/wiki/Stevens%E2%80%93Johnson_syndrome

Is steven-johnson's triggered by autoimmune cross-targeting of a skin mycoplasma and a cox-2 inhibitor?

sjs and mycoplasma
http://www.ncbi.nlm.nih.gov/pubmed/629550
http://www.ncbi.nlm.nih.gov/pubmed/4687162
http://www.ncbi.nlm.nih.gov/pubmed/8912572
http://www.ncbi.nlm.nih.gov/pubmed/4050840

acetaminophen and sjs
http://healthimpactnews.com/2013/fda-warning-acetaminophen-linked-to-fatal-skin-reactions/

acetaminophen, mycoplasmas, and maculopapular rash
http://www.ncbi.nlm.nih.gov/pubmed/23289784

lamictal and SJS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905385/

lamicatal is a cox-2 inhibitor like acetaminophen
http://www.drugdevelopment-technology.com/projects/lamictal-by-gsk/

severe skin disease and cox-2 inhibitors
http://www.ncbi.nlm.nih.gov/pubmed/16872242

UV light induces cox-2 expression
http://www.ncbi.nlm.nih.gov/pubmed/9635856

normal cox-2 is expressed primarily in the nerves but if heavy sun exposure occurs and the person takes a cox-2 inhibitor....and has skin mycoplasmas...sjs occurs?

mycoplasmas can infect the skin
http://www.atmph.org/article.asp?issn=1755-6783;year=2011;volume=4;issue=2;spage=151;epage=152;aulast=Gude

Anyone with RA or recent Pneumonia taking cox-2 inhibitors should avoid sunlight.


Saturday, June 18, 2016

Attempting to divide up the pollen and food allergies

Hypothesis: Allergies are the result of infections in the patient reacting to what we eat and breath.  The infections react then the immune system reacts to what it has suddenly seen.  Immune systems take note of everything present when "things go wrong".

We have infections living within us and all over us. Although we do not appear sick the relationship with these can alter our health.

The infections have quorums, signals between them, which mess us our body's communication and the infections have dislikes in the food we eat.

Note that some of these foods contain compounds that are both antifungal and antibacterial and are found on both lists.

Consider these "guesses" and not proven

Birch pollen and atopic dermatitis (staph)
http://www.ncbi.nlm.nih.gov/pubmed/?term=J+Allergy+Clin+Immunol+Pract.+2013%3B1(1)%3A22-28.

Birch allergy:
 apple, almond, carrot, celery, cherry, hazelnut, kiwi,
peach, pear, plum?

Birch allergy overlaps with anaphylactic peanut allergy or milk and egg sensitivities (staph makes pigments on egg and milk which is suspicious)

coconut oil is active against staph
http://www.ncbi.nlm.nih.gov/pubmed/19134433


Grass pollen and seborrheic / atopic dermatitis (malassezia or other fungal infections)
http://www.ncbi.nlm.nih.gov/pubmed/26044854
http://www.sciencedirect.com/science/article/pii/S0022202X15416860

Grass allergy overlaps with lupus autoimmune disease

Grass allergy:
celery, melons, oranges, peaches, bamboo

What do they have in common?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755671/

Note that Lemon grass is active against fungal infections: trichophyton, candida
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217679/

https://www.researchgate.net/publication/230201224_Antifungal_Activity_of_Lemon_Grass_Oil_and_Lemon_Grass_Oil_Cream

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100014

http://www.ncbi.nlm.nih.gov/pubmed/25242268

http://www.ncbi.nlm.nih.gov/pubmed/23793205

orange peel is an antifungal against aspergillus
http://www.sciencedirect.com/science/article/pii/S0956713512005294



Ragweed pollen and celiac/ dermatitis heptiformis/ ulcerative colitis (e.coli, campylobacteria/sutterella, c.diff)

Ragweed allergy:
banana, cucumber, melon, sunflower seeds, zucchini, oregano, chamomile, mums

Antibacterial in them?
http://naldc.nal.usda.gov/download/25920/PDF

banana and antibacterial
http://www.sciencedirect.com/science/article/pii/S0740002089800267

chamomile antibacterial
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995283/


Contact allergy with food: strawberry, MSG, and tomato...part of the nightshade allergy? Fibromyalgia and memory issues due to pituitary problems? (Bacteria Stenotrophomonas )


Bulb plant allergies and aspergillus? (black mold that typically grows on them)
garlic, onions, lilies




Thursday, June 16, 2016

The Human clock: a contemplation about aging (still writing and updating this)

If we really want to slow our aging we have to understand how we age. This page will be a collection of thoughts about aging in an attempt to harness the ability to control our aging.

"How and why we age" Leonard Hayflick's brilliant book is a good place to start.

One focus Hayflick has is the length of telomeres where telomeres shrink as we age and that these telomeres are counting cell divisions. When the telomeres have frayed down to nothing the cells stop dividing. Hayflick's number is the number of cell divisions permitted per cell.

Is life span determined by the number of divisions?  Are the divisions a life "counter" representing the stage of our life?

Circadian clocks and cell division
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047750/

Two clocks: the cell division cycle (CDC) and the daily (circadian) biological clock 

The circadian clock is the intertwining of the solar clock with the biological hormone clock so that biological processes occur at the right time and in the right season. (for example spring mating or melatonin triggering our sleep)

Hormone cycles might be determined by number of divisions not just solar.  We can see years of hormone cycles.

For girls:
Estrogen burst in teens at 15 causing development (average)
Estrogen burst at 30 in woman (migraines etc)  a second cycle
Estrogen at 45 missing and it is the lowest : menopause begins

Estrogen replacement studies
http://www.seattletimes.com/seattle-news/estrogen-study-uncovers-role-of-age-in-outcomes/

Breast cancer risk increased but that could be the epstein barr (a herpes virus) using the estrogen receptor.  If we remove this virus and we could remove this risk.

Should we instead of estrogen replacement be creating an estrogen burst at the age of 45?

What are the cycles in men? 

Melatonin stops being made when testosterone is being produced which causes the sleepless nights of teen boys around 15 years of age.

While women have monthly cycles, men have yearly cycles peaking in the spring and tanking to low testosterone levels in the fall.  

Do men have a burst of testosterone at 30? A window of sleepless nights then? Studies show a slowly decreasing testosterone level from the teens on.  No obvious burst.  Is this correct or is it short like the migraines of women at that age and the daily levels remain the same and decreasing? 

Should we assume that men have 15 year hormone bursts too which stop at 45 ?  Andropause?

Now that we have looked at hormones and cell cycles what else controls the cell cycle?

How closely tied is the functioning of the mitochondria and cell cycle?  

ATP is the energy currency so limiting ATP would slow the process down.

We know that occasional fasting can increase life span in mice 
http://jn.nutrition.org/content/31/3/363.extract
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466591/

Does high levels of ATP speed division up?

We are suspicious that high sugar intake in children, specifically girls, causes earlier puberties. 
https://www.newscientist.com/article/dn26868-do-sugary-drinks-trigger-early-puberty-in-girls/

In plants they are beginning to discover that it is not ATP levels that effect cell cycle rather the sugar itself that interacts with the hormones speeding the cycle up. How this works is still unclear.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667240/

At this point I think limiting our sugar intake and testing our hormone levels, keeping them average or higher, might improve our life span.

Further note that the Co-carcinogenesis hypothesis is supported by the telomere hypothesis in that the virus produces telomere stabilizing proteins that could set the cell up to be immortal...as cancer cells are.


HeLa are the immortal cancer cells take from one woman which have been dividing immortally ignoring Hayflick's number. (currently being used for cancer research)
https://en.wikipedia.org/wiki/HeLa

Flagellate dermatitis and HPV

What causes flagellate dermatitis? Is HPV there in the skin? I am suspicious because of the following:

shiitake mushrooms have a compound that appears active against HPV
http://www.dailymail.co.uk/health/article-2816049/Could-Japanese-mushrooms-kill-HPV-virus-causes-cervical-cancer.html

http://www.drweil.com/drw/u/QAA400323/Mushrooms-Against-Cancer.html

shiitake mushrooms in some individuals cause flagellate dermatitis
http://www.ncbi.nlm.nih.gov/pubmed/24940644
http://www.ncbi.nlm.nih.gov/pubmed/23837150
http://www.ncbi.nlm.nih.gov/pubmed/1395630
http://www.ncbi.nlm.nih.gov/pubmed/25386273

are these skin reactions because of skin cells infected with a type of HPV?

The drug Bleomycin also causes flagellate dermatitis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414602/
http://archderm.jamanetwork.com/article.aspx?articleid=654439

http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2013;volume=9;issue=3;spage=500;epage=503;aulast=Biswas

Bleomycin has been shown to be an anti-viral (multiple viruses)
http://www.ncbi.nlm.nih.gov/pubmed/16888741 (hepatitis C, flavivirus)
http://www.ncbi.nlm.nih.gov/pubmed/16332431 (HIV)
http://www.ncbi.nlm.nih.gov/pubmed/4135910 (vaccinia)

Does Bleomycin act on HPV too?

There are so many HPVs...which ones are found in the skin of flagellate dermatitis?

Tuesday, June 14, 2016

Does the H.pylori bind to the sodium transporters where vit C should? is that how they are holding on in the intestine?

H.pylori causes iron deficiency
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710418/
http://www.ncbi.nlm.nih.gov/pubmed/15285524

non heme iron needs vit C to be absorbed in the intestine
http://www.ncbi.nlm.nih.gov/pubmed/6940487

high dose vit C and h.pylori (vit C seems to compete?)
http://www.ncbi.nlm.nih.gov/pubmed/9926292

Sodium is required to transport vit C into the body by transporters
https://en.wikipedia.org/wiki/SLC23A1

high sodium favors h.pylori infections
http://www.ncbi.nlm.nih.gov/pubmed/23569116

Does the H.pylori bind to the sodium transporters where vit C should? is that how they are holding on?

What about the other types of spirochetes like lyme's Borrelia burgdorferi  , are they vit C sensitive?

I haven't found any scientific paper just " citris or vit C remedies" on the web by lyme disease patients.
http://www.earthclinic.com/cures/lyme_disease3.html

note that some say that the high Vit C makes the lyme disease symptoms worse
http://www.lymeneteurope.org/info/vitamin-c-a-lyme-patient-s-friend-or-foe

syphilis and vit C (from 1930s)
http://www.seanet.com/~alexs/ascorbate/193x/dainow-ann_derm_syph_1935-s7-v6-n9-p830-eng.htm

Friday, June 10, 2016

Is Rheumatoid arthritis autoimmune cross-targeting on the tendon?

Autoimmune cross-targeting hypothesis suggests that simultaneous infections on one target triggers autoimmunity.  One infection on the outside of the target cell and one infection, like a virus, on the inside of the target.  

Is Rheumatoid arthritis autoimmune cross-targeting of mycoplasma and crystalline silica or epstein barr at the tendon?

silica and RA
http://www.hindawi.com/journals/arthritis/2012/604187/

Does crystalline silica replace the virus cross-targeting with a mycoplasma?

does the body see crystalline silica as foreign?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566238/

epstein barr and RA
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526553/

estrogen receptors and tendons
http://www.ncbi.nlm.nih.gov/pubmed/21189209

previously i had looked a synovial membranes as the autoimmune target
http://angelabiggs.blogspot.com/2015/08/rheumatoid-arthritis-as-autoimmune.html

synoviocytes are cells that line tendons
http://medical-dictionary.thefreedictionary.com/synoviocyte









Myasthenia gravis, Brown's syndrome, Still's disease, and mycoplasmas


Brown's syndrome and Myasthenia gravis 
http://www.ncbi.nlm.nih.gov/pubmed/8368187

Eye muscle antibodies in MG
http://www.ncbi.nlm.nih.gov/pubmed/9646837

mycoplasma and MG
http://www.ncbi.nlm.nih.gov/pubmed/18506483

my previous post about MG (2 types)
http://angelabiggs.blogspot.com/2016/01/updated-autoimmune-cross-targeting-and.html

stills disease and brown's
http://www.ncbi.nlm.nih.gov/pubmed/3625648

Still's disease and mycoplasma
http://cid.oxfordjournals.org/content/32/6/e105.full.pdf

JIA is often called the adolescent still's disease
https://en.wikipedia.org/wiki/Juvenile_idiopathic_arthritis

juvenile idiopathic arthritis JIA
http://www.ncbi.nlm.nih.gov/pubmed/12878798

JIA, brown's, and tendons
http://www.ncbi.nlm.nih.gov/pubmed/3981317

Chick tendons and mycoplasmas
http://www.ncbi.nlm.nih.gov/pubmed/7340082

Sunday, June 5, 2016

Area Postrema and autoimmunity: Is neuromyelitis optica caused by cross-targeting here?


Hypothesis: autoimmunity is triggered by the cross-targeting of a virus marking the inside of the cell and an infection marking the outside.  One of each. If Neuromyelitis optica is autoimmune then the flu virus and either a fungus or mycoplasma will be found triggering it. 

The Area postrema is responsible for nausea and this area of the brain could be the "target".

neuromyelitis optica with lesions in the area postrema causes hiccups, nausea, vomiting
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068006/

The average time to development of these lesions after the first brain symptom was 21 months!
http://www.hindawi.com/journals/msi/2012/735486/
fi they look too soon they may not see lesions

In fact brazilian study found lesions only 50% of the time
http://www.ncbi.nlm.nih.gov/pubmed/18392403

area posterma is located right next to brain stem

https://www.google.com/search?q=area+postrema+located&espv=2&tbm=isch&imgil=WIYf19aj099DLM%253A%253BT801LTbqdDA5OM%253Bhttps%25253A%25252F%25252Fwww.cnsforum.com%25252Feducationalresources%25252Fimagebank%25252Fserotonergic%25252F5ht3_dist&source=iu&pf=m&fir=WIYf19aj099DLM%253A%252CT801LTbqdDA5OM%252C_&usg=__fgW1dXHt6Efd47emxF1_5BHEHxk%3D&biw=1050&bih=717&ved=0ahUKEwili8SS7JHNAhUIb1IKHWTfCbsQyjcISw&ei=iZtUV-WiJ4jeyQLkvqfYCw#imgdii=WIYf19aj099DLM%3A%3BWIYf19aj099DLM%3A%3BAPviZeI-_6D-AM%3A&imgrc=WIYf19aj099DLM%3A

Area postrema and D2 receptors
http://www.sciencedirect.com/science/article/pii/0014299981905409

Swine flu family viruses are linked to D2 receptors in previous post
http://angelabiggs.blogspot.com/2016/05/dopamine-receptors-and-flu-viruses-are.html

D2 receptors are on the pancreas which means a risk of type one Diabetes at the same time
http://www.ncbi.nlm.nih.gov/pubmed/16129680

swine flu is H1N1 which is influenza A

my previous post on neuromyelitis: connects influenza A with 2 types of infection
http://angelabiggs.blogspot.com/2014/08/neuromyelitisoptica-and-cross-targeting.html

interesting article: mycoplasma, NMO, and anti-aquaporin
http://www.ncbi.nlm.nih.gov/pubmed/19497587
(pneumonia)

There seem to be 2 types of NMO: monophasic and relapsing

Is the monophasic neuromyelitis optica type trigger by mycoplasms with the flu? it effects both sexes equally
https://www.researchgate.net/publication/5292135_Mycoplasma_pneumonia_as_a_cause_of_neuromyelitis_optica

The relapsing neuromyelitis optica affects woman more and has "waves " of attacks which sounds like a fungal infection. Estrogen can alter the morphology of fungal infections. (mold to yeast transitions where mold forms "disappear")

Does the fungal or mycoplasma infection create aquaporin antibodies? Can the antibodies alone trigger the autoimmune disease with a flu virus? Aquaporin proteins of the human body are highest in the CNS that are targeted in NMO.

If this is true then it means another infections like t.gondii or strep can open up the blood brain barrier which allowed the flu virus and the aquaporin antibodies in. (normally viruses and antibodies cannot reach the brain)

Is that why this disease is rare? 3 infections needed? Or can fungal infections cross the blood brain barrier which means that the remitting NMO is more common? more woman have this disease?

dicord lupus and nmo (Trichophyton)
http://www.ncbi.nlm.nih.gov/pubmed/19745613
http://www.ncbi.nlm.nih.gov/pubmed/11036404

sjogren's and nmo (candida)
http://www.ncbi.nlm.nih.gov/pubmed/26938585
http://www.ncbi.nlm.nih.gov/pubmed/21844143

aspergillus and NMO
http://www.ncbi.nlm.nih.gov/pubmed/27031126

mycoplasmas and NMO
http://www.ncbi.nlm.nih.gov/pubmed/18563469

Mycoplasmas (RA) and biofilms
http://www.ncbi.nlm.nih.gov/pubmed/16549656
http://www.ncbi.nlm.nih.gov/pubmed/19443045

candida and biofilms
http://mic.sgmjournals.org/content/157/11/3232.full.pdf

in yeast aquaporins help biofilms form
http://www.sciencedirect.com/science/article/pii/S0304416513004121

candida and aquaporins
http://aem.asm.org/content/71/10/6434

NMO has anti-aquaporins
http://www.ncbi.nlm.nih.gov/pubmed/17439296

specifically aquaporin4 is the water channel of the central nervous system and the specific channel in NMO that has antibodies against it
http://www.nature.com/nrn/journal/v14/n4/full/nrn3468.html

Further: Can crystal meth replace the virus triggering the autoimmune cross-targeting? Are users at risk of developing NMO?

Note that 10-15% of NMO cases do not have aquaporin antibodies or lesions so in a small percent something is replacing the mycoplasmas and fungal infections.
http://www.ncbi.nlm.nih.gov/pubmed/26950113

Sexes affected equally when no aquaporin antibodies yet NMO
http://www.ncbi.nlm.nih.gov/pubmed/23658379

A small group of NMO have been associated with ulcerative colitis

I had associated c.soridella with ulcerative colitis (a relative of c. difficile that secretes an acid similar to h.pylori thus causing the ulcers)
http://angelabiggs.blogspot.com/2013/05/ulcerative-colitis.html

C.diff or C. sordellii secrete a Toxin B that effects water channels (aquaporins)
http://www.ncbi.nlm.nih.gov/pubmed/12640036
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250724/

Could the group negative for the antibodies be the group triggered by the ToxinB? 










Friday, June 3, 2016

Carcinogens using receptors to enter cells


Francis Peyton Rous' Co-carcinogenesis hypothesis: that a virus and a carcinogen together cause cancer. (1966 Nobel prize for HPV work) The co-carcinogenesis hypothesis was published in 1944  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135410/

My co-carcinogenesis takes his further because carcinogens inhibit polymerases.

(yes we have been told carcinogens cause DNA damage but I think their ability to inhibit polymerases causes most cancer. The cancers have patterns, cancer families, and are not that chaotic)

Alone a carcinogen would inhibit growth of the cell until a virus appears opens up the DNA and modifies the cell to create virus supplies for ever.  The problem is the carcinogen inhibits the viral polymerase better than the human polymerase.  So instead of the virus making what it wants the infected cell is transformed into a cancer cell.

Different carcinogens are absorbed by different areas of the body through receptors. Viruses also use receptors.

Estrogen receptors: Benzene/phenols and herpes viruses

https://academic.oup.com/toxsci/article/54/1/138/1670624/The-Estrogen-Receptor-Relative-Binding-Affinities

Estrogen receptors: heptachlor

https://books.google.com/books?id=utm6BQAAQBAJ&pg=PA195&lpg=PA195&dq=heptachlor+estrogen+receptor&source=bl&ots=Ivpog3RvK2&sig=GeZodD2n7fKnjxqlUEz6yoqPfnA&hl=en&sa=X&ved=0ahUKEwinzL-g1I7TAhUlHGMKHRFCBJwQ6AEINjAD#v=onepage&q=heptachlor%20estrogen%20receptor&f=false

Melanocortin receptors/ estrogen receptors:  Organochlorides and flaviviruses/herpes

https://books.google.com/books?id=n_tXscNndysC&pg=PA86&lpg=PA86&dq=Organochlorines+bind+receptors&source=bl&ots=MCUZ54oDQ2&sig=GVoiK-Hwc__98Z1v2q-PdDLaFDY&hl=en&sa=X&ved=0ahUKEwj3oL28047TAhVCxFQKHXXEBasQ6AEIJjAC#v=onepage&q=Organochlorines%20bind%20receptors&f=false

Acetylcholine receptors: nitrates/nitrites and enteroviruses

https://www.ncbi.nlm.nih.gov/pubmed/15551380

Gaba receptors: alcohol

http://www.pnas.org/content/103/22/8307.full

gaba receptors are found in pancreatic as well as nerves
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217445/

Dopamine receptors: flu virus

dopamine receptors are found in pancreatic cells
http://www.jbc.org/content/280/44/36824.long

I have only matched these carcinogens and viruses through receptors.  I am just suggesting these have a higher likelihood of causing cancer together because they tend to pick the same cells. However a carcinogen and a virus can use different paths to get into the same cell. (they don't have to use the same receptor as I have shown with pancreatic cancer)

Possible???


Acetylcholine receptors, nitrates/nitrites, enteroviruses, and cancer

Logically cells that involve acetylcholine receptors would end up with nitrates and nitrites in them. Have the carcinogen there does not cause cancer until a virus infects the same cell.

Enteroviruses look like they infect using the same acetylcholine receptors
http://angelabiggs.blogspot.com/2015/07/enteroviruses-and-acetylcholine.html

Only when both are there does co-carcinogenesis occur resulting in cancer.

Co-carcinogenesis : Rous' hypothesis requires a virus and a carcinogen together to start cancer.

My co-carcinogenesis takes his further:  Carcinogens inhibit polymerases.

(yes we have been told carcinogens cause DNA damage but I think their ability to inhibit polymerases causes most cancer. The cancers have patterns and are not that chaotic)

Alone a carcinogen would inhibit growth until a virus appears opens up the DNA and modifies the cell to create virus supplies for ever.  The problem is the carcinogen inhibits the viral polymerase better than the human polymerase.  So instead of the virus making what it wants the infected cell is transformed into a cancer cell.

Different carcinogens are absorbed by different areas of the body. The post suggests that nitrates/nitrites are taken up by acetylcholine receptor cells.

sh groups and acetylcholine
http://www.sciencedirect.com/science/article/pii/0014579377800549

nitrates,vascular muscle relaxation and sh groups
http://www.ncbi.nlm.nih.gov/pubmed/6816463

acetylcholine is a neurotransmitter
http://www.ncbi.nlm.nih.gov/books/NBK11143/

hot dogs and brain tumors in children and pancreatic cancer in adults
http://www.processedfreeamerica.org/resources/health-news/355-hot-dogs-cause-brain-tumors-in-children

Pancreas and acetylcholine receptors
http://www.pnas.org/content/107/40/17397.full.pdf

Gastric cancer and nitrates? it is being debated
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690057/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2062934/

gastric chief cells and acetylcholine
https://en.wikipedia.org/wiki/Regulation_of_gastric_function

coxsackie infection blocked by nicotine
http://www.ncbi.nlm.nih.gov/pubmed/26851533


Thursday, June 2, 2016

How is Amyotrophic lateral sclerosis, vit D, Tau protein, and organochlorides connected?

Organochlorides can cause parkinson's and cancer by infected melanoma containing cells but they have also been linked to cases of ALS. How? Does the cl- bind vit D channels like aflatoxin? Does it then bind hsp70? is that how they are linked to the creation of Tau ?


Is ALS triggered by aflatoxin like compounds and tau is produced? Previous post i am building on.
http://angelabiggs.blogspot.com/2016/05/amyotrophic-lateral-sclerosis-and.html

aflatoxin binds the Vit D receptor
https://www.citeab.com/publication/1455664-25483621-toxicity-of-aflatoxin-b1-towards-the-vitamin-d-rece

Tau has been found to be reduced with vit D supplementation
http://www.ncbi.nlm.nih.gov/pubmed/24412233

organochloride pestides and vit D deficiency
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266254/

some forms ALS caused by organochlorides
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358481/

Vit D has been shown to slow the progression of ALS
http://www.ncbi.nlm.nih.gov/pubmed/24428861

do organochlorides bind the vit D receptor as well as the melatonin receptor?

note that the vit D receptor controls the Chloride channel
http://www.ncbi.nlm.nih.gov/pubmed/21659475

Does Cl bind these particular vit D receptors as a form of feed back regulation?

note that the organochloride "dieldrin" causes Tau protein

https://books.google.com/books?id=otQw-eo1aA0C&pg=PT314&lpg=PT314&dq=organochlorine+tau+protein&source=bl&ots=N0XaZ3LiGA&sig=tVcc99MHxHBAKZYaecytuMAY8HU&hl=en&sa=X&ved=0ahUKEwj8xIzcw4rNAhViE1IKHW18BKcQ6AEITzAH#v=onepage&q=organochlorine%20tau%20protein&f=false

Dieldrin creates the amyloid protein by destroying the mitochondria too.

organochlorides, alzheimer's, and amyloid
http://angelabiggs.blogspot.com/2016/06/is-reason-chlordane-triggers-alzheimers.html

further are there high levels of vit D receptors in breast tissue and could this explain why so much heptachlor is stored there?
http://www.ncbi.nlm.nih.gov/pubmed/7881099

note that Vit D cycles to the cytosol where it binds a type of hsp70
http://www.reactome.org/content/detail/209766

Hsp70 is known to bind tau
http://www.ncbi.nlm.nih.gov/pubmed/20308058
http://www.ncbi.nlm.nih.gov/pubmed/25882706

an imbalance of hsp70 family proteins causes tau accumulations!
http://www.ncbi.nlm.nih.gov/pubmed/23271055

Does aflatoxin or dieldrin bind not just to the vit D receptor but once in the cytosol do they bind the hsp70? is this why aflatoxin causes microtubule issues?

cells treated with aflatoxin increase expression of hsp70
http://www.ncbi.nlm.nih.gov/pubmed/15037034

previous aflatoxin post
http://angelabiggs.blogspot.com/2016/04/what-does-aflatoxin-do-mitochondria-of.html

like heptachlor does aflatoxin increase the risk of breast cancer? maybe
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567057/


Benzene, the carcinogen, binds estrogen receptors

Benzene and estrogen receptors
http://www.ncbi.nlm.nih.gov/pubmed/11137303

Benzene associated cancers: lymph and bone

Leukemia and benzene
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447593/

Benzene and breast cancer
http://www.ncbi.nlm.nih.gov/pubmed/19366049

note that the estrogen receptors of nerves cycle to the mitochondria instead of to the nucleus therefore Benzene doesn't cause cancer at nerves.

Does benzene cause damage to the mitochondria of nerves since it is going there?

Exposure to the solvents like benzene has been found to be a risk factor for Alzheimer's
http://www.ncbi.nlm.nih.gov/pubmed/7771442

alzheimer's and the mitochondrial damage of neurons
http://angelabiggs.blogspot.com/2015/08/alzheimers-and-dysfunctional.html

Does benzene cause cancers that involve cells with estrogen receptors?








Wednesday, June 1, 2016

Does chlordane trigger Alzheimer's because it destroys the mitochondria? why does chlordane and heptane prefer melatonin containing cells?

Previously heptachlor was found to trigger parkinson's
http://www.aboutlawsuits.com/milk-parkinsons-disease-study-91199/

I suggested this was because the heptachlor can replace the virus in the autoimmune cross-targeting hypothesis.
http://angelabiggs.blogspot.com/2015/12/not-just-flu-but-flaviviruses-and.html

Now in addition to parkinson's disease chlordane and heptachlor have been associated with Alzheimer's. What is happening? I have previously suggested that Alzheimer's is caused by damaging the mitochondria of nerves.
http://angelabiggs.blogspot.com/2015/08/alzheimers-and-dysfunctional.html

cis-chlordane 5X increase in Alzheimer's
http://www.alzforum.org/news/research-news/pesticides-raise-risk-als-and-potentially-alzheimers-disease

chlordane and heptachlor are closely related
https://en.wikipedia.org/wiki/Chlordane

chlordane and heptachlor and the rat liver
https://www.jstage.jst.go.jp/article/joma1947/102/11-12/102_11-12_1345/_article

heptachlor destroys the mitochondria
http://www.ncbi.nlm.nih.gov/pubmed/23867817

Heptachlor can induce parkinsonism by killing the NS cells
http://www.ncbi.nlm.nih.gov/pubmed/24577234

Chlordane effects the nervous system by damaging the mitochondria of the nerves

This is separate from it's ability to cause cancer with a virus where the viruses polymerase is inhibited much like chlorine does.

Heptachlor has been associated with prostate cancer where it could be inhibiting the polymerase of flaviviruses . Does it increase melanoma in those exposed to pesticide and flaviviruses?

Melanoma was thought to be connected to heptochlor
https://books.google.com/books?id=h70DCwAAQBAJ&pg=PA23&lpg=PA23&dq=organochlorine+insecticides+melanoma&source=bl&ots=-HtNZpW9xJ&sig=hj740xTOwAWDUqkaOsjmnlRbVc8&hl=en&sa=X&ved=0ahUKEwi1xf3H2InNAhVPTFIKHetDDGUQ6AEITjAI#v=onepage&q=organochlorine%20insecticides%20melanoma&f=false

But then a "take home questionnaire" saw no connection
http://www.ncbi.nlm.nih.gov/pubmed/17096337

It would be nice to have a more scientific study to be done because the higher rates of melanoma and working with pesticides is real
http://www.scientificamerican.com/article/farm-pesticides-linked-to-skin-cancer/

Is heptachlor and chlordane attracted to melatonin containing cells?

Melatonin is said to control the secretion of Cl-
http://jpet.aspetjournals.org/content/352/1/119.full

can Cl- bind the receptors as well as melatonin ? Is chlordane or heptachlor binding melatonin receptors? We can see it in the same cell tissues as flaviviruses which I suspect use melanocortin receptors.