Monday, September 29, 2014

Gluten and Casein signifies that infections are crossing the major barriers: the intestine or the blood-brain-barrier !!!

Gluten and casein sensitivity may mean that an infection has broken through a tight barrier like the intestine or brain's blood barrier.

Does casein-alpha or gluten alter the IFN which then allows the BBB or the lumen to open for bacterial infections to cross? 

Under normal conditions IFN is a cytokine, a immune system message, to tell macrophages to come eat something.   If IFN levels are raised too high in an area the barrier wall epithelial layer goes through changes.  (zonulin included ) Which means that infections which try to cross either the blood brain barrier or the lumen would have an easier time. 

The hypothesis is that the high IFN levels from a gluten and casein sensitive state would create antibodies but not autoimmune disease until a virus infects the same area causing cross-targeting.

Cross-targeting autoimmune hypothesis is 2 infections on one target, one organ, confuse the immune system into attacking self.  An outer infection to uncouple the B cell's education and an inner infection to uncouple a T cell's education.

Gluten sensitivity alone is not an indicator of autoimmune disease rather that an infection exists that breaks barriers.

First let us look at the gluten and casein connection to IFN.

differences alpha, beta, gamma IFN
http://www.ncbi.nlm.nih.gov/pubmed/7993128

all are involved with cell growth inhibition in addition to being part of the immune system cytokines against viruses...all can open the Blood Brain Barrier or BBB

Casein-alpha upregulates IFN-alpha genes thus functions as a tumor suppressor
http://www.landesbioscience.com/journals/cc/2012CC4423.pdf 

temporary bbb crossing blocked but long term opens it?
http://www.researchgate.net/publication/5257154_Interferon-beta_prevents_cytokine-induced_neutrophil_infiltration_and_attenuates_blood-brain_barrier_disruption

Gluten stimulates more IFN-gamma expression is gluten inhibiting it?
http://www.gastrojournal.org/article/S0016-5085%2898%2970134-9/abstract 
http://www.ncbi.nlm.nih.gov/pubmed/9721152 
http://www.ncbi.nlm.nih.gov/pubmed/23588237
http://www.ncbi.nlm.nih.gov/pubmed/17919493

IFN-γ participates in cerebral malaria pathogenesis by affecting endothelial integrity
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133756/

f-actin and gluten
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809109/

e.coli, f-actin and the BBB
http://www.ncbi.nlm.nih.gov/pubmed/24932957

casein from milk increases mycobacteria invasion
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459753/

B-casein from bacteria and cellular motility /invasion?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC275444/
pretty pictures of what casein induces and the visualizing of actin (same article)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC275444/figure/cdg586f4/

Current hypothesis list of gluten and casein sensitive culprits connected to autoimmune diseases:

e.coli celiac
sutterella autism
mycobacteria psoriasis/parkinson's
 t.gondii schizophrenia
strep tourettes (non genetic)

e.coli and gluten
http://www.ncbi.nlm.nih.gov/pubmed/26456581

Strep and gluten
http://www.ncbi.nlm.nih.gov/pubmed/15814071

t.gondii and gluten sensitivity
http://www.ncbi.nlm.nih.gov/pubmed/23209841

psoriasis and gluten
http://www.ncbi.nlm.nih.gov/pubmed/25603678

psoriasis and mycobacteria

gluten and pychosis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517012/


If they all are gluten sensitive because they cross the BBB (blood brain barrier) does that mean that Strep would be gluten sensitive because it is notorious for crossing and has been known to be involved with PANDAS which involves antibodies passing through a BBB to get to the brain.

Anyone out there able to look at strep and see if it is gluten and casein sensitive?
http://www.ncbi.nlm.nih.gov/pubmed/15814071
http://curemyth1.org/forum2/3860.html
http://wheatfreediseasefree.com/2012/04/23/keep-the-tonsils-pull-the-strep-throat/
We so quickly give people antibiotics I am not sure we will know.

strep and OCD?
http://www.ncbi.nlm.nih.gov/pubmed/15995031

OCD and gluten? is this strep or e.coli
http://www.ncbi.nlm.nih.gov/pubmed/?term=ocd+gluten

In case you did not know that e.coli crossed the BBB
http://iai.asm.org/content/69/9/5217.full?sid=41faac6f-bc5d-4015-bd6d-8f733682da01 

strep and ataxia
http://www.ncbi.nlm.nih.gov/pubmed/15814071 

Zonulin is also an interesting dimension appearing at the lumen of the gut and the blood brain barrier
http://www.ncbi.nlm.nih.gov/pubmed/23637756
http://www.ncbi.nlm.nih.gov/pubmed/22731712


How does all this fit together? Transglutaminase and cross-targeting?

viral infections can  cause the generation of Transglutaminase
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810390/

further EBV may set off more than one type of colon autoimmune disease (not just celiac)
http://www.ncbi.nlm.nih.gov/pubmed/10364028

Infections like e.coli or strep which would cross the lumen or BBB with increased ease with gluten and casein would already have the generated and immune attack there in the colon but it would not be autoimmune until cross-targeted with a virus.

In other words it is not the "crossing of gluten and casein"  that we should  fear rather the  cross-targeting of infections and the antibodies that target us.

3/5/2015 new post http://angelabiggs.blogspot.com/2015/03/infections-that-break-tight-junction.html

New paper linking intestinal lumen and the BBB. When the intestine becomes stronger so does the BBB.
http://www.ncbi.nlm.nih.gov/pubmed/25411471



Guillain barre syndrome and autoimmune cross-targeting

Guillain Barre

Old blog post: http://angelabiggs.blogspot.com/2013/04/does-location-of-bacteria-decide-which.html

Current virus hitting denver and paralysis is not Guillan Barre
http://abcnews.go.com/Health/cdc-investigates-limb-paralysis-children-enterovirus-68-outbreak/story?id=25804998
They found anti-phospholipid antibodies. So it is the autoimmune disease transverse myelopathy which overlaps sjogren's.
http://www.ncbi.nlm.nih.gov/pubmed/10930601

My Hypothesis:
Cross-targeting:  the layering of 2 different infections on one target causes autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria..etc.. infection marking the outside.

In the case of Guillain Barre

Campylobacter jejuni
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC128258/ 
http://www.ncbi.nlm.nih.gov/pubmed/24107359 
http://www.ncbi.nlm.nih.gov/pubmed/16829615

Enterovirus
http://www.ncbi.nlm.nih.gov/pubmed/16269848

other viruses might trigger the cross-targeting
http://www.ncbi.nlm.nih.gov/pubmed/24800041 

c.jejuni and the lungs ??? some cases of asthma????
http://www.unboundmedicine.com/medline/citation/24611115/Campylobacter_jejuni_infection_of_infant_mice:_acute_enterocolitis_is_followed_by_asymptomatic_intestinal_and_extra_intestinal_immune_responses_ 

Indirect connection H.pylori protects against early on-set asthma and c.jejuni
http://www.ncbi.nlm.nih.gov/pubmed/?term=c.+jejuni+asthma

Sunday, September 28, 2014

Friday, September 26, 2014

Are cataracts caused by autoimmunity?


Antibodies against lens proteins in Cataract patients
http://www.ncbi.nlm.nih.gov/pubmed/15636218
http://www.ncbi.nlm.nih.gov/pubmed/3111983

crystallins and cataracts
http://www.ncbi.nlm.nih.gov/pubmed/19007775

senile cataract: no infection? old age?
http://www.ncbi.nlm.nih.gov/pubmed/19023447 

why would our bodies generate antibodies against crystallin? have some of these infections started using crystallin? http://www.ncbi.nlm.nih.gov/pmc/articles/PMC43774/    It appears bacteria can look similar!!

Looking for overlaps with infections and this bacteria...staph
http://jb.asm.org/content/early/2014/09/23/JB.02217-14.abstract?related-urls=yes&legid=jb;JB.02217-14v1

Crystallins appear to be used by the immune system to protect the eye during infection too.
http://www.ncbi.nlm.nih.gov/pubmed/19860667

  Is it used by the immune system elsewhere?

crystallins in autoimmune diseases
http://www.google.com/patents/EP0764273B1?cl=en
(note that i have suggested that staph or mycobacteria are involved in triggering MS with cross-targeting autoimmunity)

the accumulations of cyrstallin in the central nervous system
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1886422/pdf/amjpathol00086-0102.pdf
http://www.ncbi.nlm.nih.gov/pubmed/11200685

MS and crystallins
http://www.ncbi.nlm.nih.gov/pubmed/16764341
http://med.stanford.edu/news/all-news/2007/06/stanford-researchers-clarify-proteins-role-in-multiple-sclerosis.html
http://www.ncbi.nlm.nih.gov/pubmed/10478576


cataracts and eczema (staph)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2161383/
http://www.bmj.com/content/1/4183/356
books.google.com/books?id=5R8JRtYmleAC&pg=PA126&lpg=PA126&dq=eczema+cataract&source=bl&ots=CMO_9pOTLm&sig=r3k672TmqoCpluPWFOYOQ27HsKE&hl=en&sa=X&ei=K5MlVMmPIYaayQTOyoKQDw&ved=0CC8Q6AEwAzgK#v=onepage&q=eczema cataract&f=false 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292870/

Staph and crystallin
http://www.ncbi.nlm.nih.gov/pubmed/18227158
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292870/


cataracts and psoriasis/ type 2 diabetes (mycobacteria)
http://www.ncbi.nlm.nih.gov/pubmed/3805392
http://www.uveitis.org/docs/dm/psoriatic_arthritis.pdf 

mycobacteria and crystallins
http://www.ncbi.nlm.nih.gov/pubmed/15778386

cataracts and type 1 diabetes/celiac (e.coli)
http://www.ncbi.nlm.nih.gov/pubmed/21624959

celiac and crystallins
http://www.ncbi.nlm.nih.gov/pubmed/11593501

So several bacterias need to be checked to see if their coat has crystallin:
staph, e.coli, and mycobacterias

Tuesday, September 23, 2014

Lupus vs. Sjogren can you separate them with transglutaminase?

This board is still under construction

Higher levels of transglutaminase in Sjogren's than in Lupus and RA
http://www.ncbi.nlm.nih.gov/pubmed/21413148

Candida and transglutaminase:  the Hypyal wall protein is a substrate for transglutaminase and is involved with the attachment to epithelial walls
http://www.jbc.org/content/279/39/40737.full

 the gluten and casein could be triggering dimorphic switching fungal infections (mold to yeast) but which enzyme it would be acting on is unknown but this would be anti-gluten not anti-transglutaminase....but is it lupus or sjogren that has gluten: http://ard.bmj.com/content/63/11/1501.full
sjogren has the gluten sensitivity : http://www.ncbi.nlm.nih.gov/pubmed/17613926
http://www.ncbi.nlm.nih.gov/pubmed/13680146
http://celiacdisease.about.com/od/commoncomplicationsofcd/a/Celiac-Disease-Sjogrens-Syndrome.htm

Lupus and RA have Wibg antibodies???? do mycoplasmas use them???? Later post

If fungal infections are involved with Sjogren's, Hashimoto's, vitiligo, colitis, and asperger's....are all of these associated with higher Transglutaminase antibodies?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604853 
 which is a vitiligo paper

Found at high levels in both Lupus and sjogren is ROs and correlated with Rheumatoid factor? What is common here between mycoplasmas and fungal infections that would do this?
http://www.ncbi.nlm.nih.gov/pubmed/1603204


RA, stroke, irregular heartbeats, and mycoplasmas?

Thursday, September 18, 2014

juvenile idiopathic arthritis and celiac disease....e.coli?

Hypothesis:
Cross-targeting:  the layering of 2 different infections on one target causes autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria..etc.. infection marking the outside.


http://www.ncbi.nlm.nih.gov/pubmed/23448357

Celiac aand Juvenile idopathic arthritis
http://www.ncbi.nlm.nih.gov/pubmed/22472933
http://www.ncbi.nlm.nih.gov/pubmed/15695302

e.coli and JIA
http://www.ncbi.nlm.nih.gov/pubmed/17469159

 urinary track infection and JIA
http://www.ehealthme.com/cs/juvenile+arthritis/urinary+tract+infection

reactive arthritis and urinary tract infections
http://www.niams.nih.gov/Health_Info/Reactive_Arthritis/

do kids with JIA get Dermatitis Herpetiformis (blistering chronic skin disease)?
 
celiac and uvetis
http://www.ncbi.nlm.nih.gov/pubmed/22408231
http://link.springer.com/article/10.1007%2Fs00296-009-1177-z#page-1

chronic uveitis (arthritis of the eye) and JIA
http://www.ncbi.nlm.nih.gov/pubmed/16395772
http://www.ncbi.nlm.nih.gov/pubmed/21378109
http://www.ncbi.nlm.nih.gov/pubmed/15693100

virus triggered
http://www.ncbi.nlm.nih.gov/pubmed/22825024

schnitzler syndrome? how rare is this?
http://www.ncbi.nlm.nih.gov/pubmed/23812931
http://www.ncbi.nlm.nih.gov/pubmed/18371052

the adult stiff syndrome and some children with  JIA ...not the same thing!!
http://www.ncbi.nlm.nih.gov/pubmed/20676642

Wednesday, September 17, 2014

discord lupus and Vitiligo with autoimmune cross-targeting?

Hypothesis:
Cross-targeting:  the layering of 2 different infections on one target causes autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria..etc.. infection marking the outside.


discord lupus and vitiligo
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673375
http://www.ncbi.nlm.nih.gov/pubmed/23741668
http://www.ncbi.nlm.nih.gov/pubmed/19061609
http://www.ncbi.nlm.nih.gov/pubmed/11036404
http://www.ncbi.nlm.nih.gov/pubmed/2061464
http://www.ncbi.nlm.nih.gov/pubmed/3250928
http://www.ncbi.nlm.nih.gov/pubmed/6724779
http://www.ncbi.nlm.nih.gov/pubmed/4086055
http://www.ncbi.nlm.nih.gov/pubmed/7235502

Trichophyton infections and discoid lupus
http://www.ncbi.nlm.nih.gov/pubmed/23177820
http://www.ncbi.nlm.nih.gov/pubmed/11036404
http://www.ncbi.nlm.nih.gov/pubmed/16922789

vitiligo and spondyloarthritis
http://www.ncbi.nlm.nih.gov/pubmed/?term=spondyloarthritis+vitiligo+2001
http://www.ncbi.nlm.nih.gov/pubmed/18182816

Which virus triggers the cross-targeting causing the discord lupus?

Discord lupus and human herpes virus 6
http://www.ncbi.nlm.nih.gov/pubmed/23983182

vitiligo and herpes zoster
http://www.ncbi.nlm.nih.gov/pubmed/4086055

discord lupus, squmous cell cancer, and Human papillomavirus
http://www.ncbi.nlm.nih.gov/pubmed/21140928
http://www.ncbi.nlm.nih.gov/pubmed/25151614

Human papillomavirus and sclerosis
http://www.ncbi.nlm.nih.gov/pubmed/25151849

Tuesday, September 16, 2014

Is idopathic thrombocytopenic purpura caused by cross-targeting autoimmunity? H.pylori and zika?

Idopathic thrombocytopenic purpura

Cross-targeting:  the layering of 2 different infections on one target causing autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria..etc.. infection marking the outside.

In most cases of Idopathic thrombocytopenic purpura, H.pylori marks the outside of the host's platelets.

ITP antibodies to platelets
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538143/

Eradication of H.pyloir has been shown to help or cure ITP

H. pylori
http://www.ncbi.nlm.nih.gov/pubmed/24505529
http://www.ncbi.nlm.nih.gov/pubmed/21120192
http://www.ncbi.nlm.nih.gov/pubmed/15765778
http://www.ncbi.nlm.nih.gov/pubmed/11157503

note that H. pylori replicates inside of bone marrow derived dendritic cells and it would be a small leap to believe that it could eventually infect other bone marrow derived cells like platelets or in infecting these types of marrow cells accidentally triggering antibodies toward platelets

The question I have : do other spirochetes infect the bone marrow? Does syphillis' t. pallidum or  lyme's b.burgdorferi or the dog spirochete leptospira???

However other infections can cause ITP...the key is that they generate antibodies against platelets. Here  are examples of mycoplasmas: http://www.ncbi.nlm.nih.gov/pubmed/19474700
http://www.ncbi.nlm.nih.gov/pubmed/19474700 
(the mycoplasma cases would have RA)

More than one virus may be able to cause the necessary cross-targeting on platelets but they must somehow infect or generate antibodies against platelets:

Flaviviruses infect bone marrow and should trigger it
dengue and ITP
http://www.ncbi.nlm.nih.gov/pubmed/24879007
http://www.ncbi.nlm.nih.gov/pubmed/26434084
http://www.ncbi.nlm.nih.gov/pubmed/25728040

Added 4/30/1016 : Zika and ITP
http://www.theguardian.com/world/2016/apr/30/zika-virus-symptoms-american-death-puerto-rico-risks

Hepatitis C and ITP
http://www.ncbi.nlm.nih.gov/pubmed/24457056
http://cid.oxfordjournals.org/content/39/6/790.full

Hepatitis C infecting the bone marrow (which would include platelet cells)
http://www.ncbi.nlm.nih.gov/pubmed/21188328

influenza A and ITP
http://www.ncbi.nlm.nih.gov/pubmed/15614463
http://www.ncbi.nlm.nih.gov/pubmed/21962253

Influenza A absorbed by platelets
http://www.bloodjournal.org/content/28/2/213?sso-checked=true 

Note that there is a strong overlap with Primary biliary cirrhosis (an autoimmune disease of the liver) and ITP
http://www.ncbi.nlm.nih.gov/pubmed/9185750  which makes sense because some of these infections are known to infect liver cells in addition to the fact that the liver filters the blood.