Still's disease (Juvenile arthritis ) is it autoimmune cross-targeting?

Autoimmune Hypothesis: An infection builds up antibodies in the early stages then a viral infection causes cross targeting triggering the autoimmune disease.

Page under construction still

Staph pyogenes and Still's disease
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888950/?page=1


Septic Arthritis and still's disease mixed up?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341832/

Epstein Barr and cytomegalovirus infecting synovium tissue
http://www.ncbi.nlm.nih.gov/pubmed/15044921

Epstein Barr and Still's disease
http://www.ncbi.nlm.nih.gov/pubmed/23166163
http://www.ncbi.nlm.nih.gov/pubmed/22370999
http://www.ncbi.nlm.nih.gov/pubmed/9855218 

Does the cross targeting occur on the synovium tissue of the joint?

Idiopathic Juvenile arthritis and Epstein Barr
http://www.ncbi.nlm.nih.gov/pubmed/19093474
http://www.ncbi.nlm.nih.gov/pubmed/9855218
http://www.ncbi.nlm.nih.gov/pubmed/22057635
http://www.ncbi.nlm.nih.gov/pubmed/22589331

Juvenile arthritis and Staph
http://www.ncbi.nlm.nih.gov/pubmed/834493
http://www.ncbi.nlm.nih.gov/pubmed/19579150

I have associated eczema with staph...so i need to look and see if there is an overlap with eczema and Juvenile arthritis.

Microscopic and Lymphocytic colitis are they fungal?

Autoimmune Hypothesis: a dimorphic infection produces antibodies until a secondary viral infection produces antibodies that cross-target thus triggering the autoimmune disease.

collagenous colitis and lympocytoic are different forms of IBS microscopic colitis
 Lymphocytic colitis tends to be the non bloody diarrhea form.

Microscopic divided into Collagenous and Lymphocytic
http://www.ncbi.nlm.nih.gov/pubmed/2912870

Collagenous microscopic colitis is associated with anti-saccharomyces antibodies
http://www.ncbi.nlm.nih.gov/pubmed/?term=collagenous+colitis+saccharomyces
http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2005.04027.x/abstract

IBS and candida
http://www.ncbi.nlm.nih.gov/pubmed/20885347

Lymphocytic colitis is associated with Candida
http://www.ncbi.nlm.nih.gov/pubmed/23314667

 Lymphocytes actually bind the candida
http://www.ncbi.nlm.nih.gov/pubmed/11796578
http://www.ncbi.nlm.nih.gov/pubmed/8660804

Microscopic colitis affects women more often then men
http://www.ncbi.nlm.nih.gov/pubmed/20878755

Fungal infections change morphology with estrogen. It is possible that these fungal infections generate the antibodies as they peek-a-boo between mold and yeast forms. Since soy is a natural estrogen a patient may be sensitive to soy.  (E.coli which I have connected to Celiac disease is not a fungal infection and is probably not estrogen or soy sensitive.)

Another difference between celiac disease and IBS maybe the gas produced after sugar intake.  Fungal infections feed on sugar and produce gas.

 ( E.coli would not do this thus true celiac disease does not have the bloating after sugar intake rather e.coli turns the sugar into a slime which is seen as mucus in the diarrhea however....c.diff or c.sordelli does make gas)

Remember this is a hypothesis blog. This has not been proven but I am suggesting how things could be occurring.  

If the infections are playing peek-a-boo...and tons of antibodies are being generated what then pushes the immune system into attack, into what we truly call an autoimmune disease I believe requires an virus.

The Viral cross-targeting the intestine seems likely to be the rotavirus or norovirus or cytomegalovirus
http://www.ncbi.nlm.nih.gov/pubmed/17249458

Is IBS merely fungal infections? For the damage to the intestine to occur does the virus have to be there? Is it really an autoimmune disease or just inflammation looking for the virus?

I hope my thoughts help someone out there figure out their disease.
Angela Biggs

UPDATED Feb 25 2016: Gluten sensitivity means you have an infection that crosses barriers : intestinal or blood brain barrier

Is Ulcerative Colitis a c.sordellii infection?

Autoimmune Hypothesis: an infection like C. difficile first builds up antibodies then a virus cross-targets the same focus triggering the autoimmune disease.

(this page is still being worked on)

 c.diff and ulcerative colits
http://www.ncbi.nlm.nih.gov/pubmed/12974208

anti-lactoferrin antibodies in ulcerative colitis
http://www.ncbi.nlm.nih.gov/pubmed/8432453
http://www.ncbi.nlm.nih.gov/pubmed/19758145

Lactoferrin is an antimicrobial protein of our innate immune system. It is found in mucus. The intestine is considered a mucosal membrane. Perhaps the cross-targeting focus is the intestine.

Lactoferrin extremely high amounts and C. diff
http://www.ncbi.nlm.nih.gov/pubmed/23135940
http://www.ncbi.nlm.nih.gov/pubmed/20439046

Epstein-barr virus (mononucleosis)  and Ulcerative colitis
www.annalsgastro.gr/index.php/annalsgastro/article/view/799/593
http://www.ncbi.nlm.nih.gov/pubmed/23574759
http://www.ncbi.nlm.nih.gov/pubmed/2103
this virus can infect the intestine

 My hypothesis is : The c.diff does not alone cause the ulcerative colitis or the epstein-barr virus independently. The cross-targeting of the 2 together that sets off the immune system.

 Other thoughts and questions:

 The ulcerative colitis herbal remedy is said to be chamomile.
People with ulcerative colits  might have daisy flower family allergies. Any one have evidence of this? further some latex is made from dandelions which could cause some people to develop a latex allergy.

Since ulcerative colits is said to be milk and egg sensitive I have been looking to see if the yellow diarrhea is connected to c.diff pigment similar to the staph pigment when plated on egg.  anyone know the answer?

Even more interesting 8/30 thoughts from a newer post:

My thoughts....c.diff may not really be the culprit. C. sordellii which is closely related makes urease like H. Pylori.  H. pylori we know causes ulcers.


Hopeful,
Angela Biggs

Sjogren's is it caused by cross-targeting autoimmunity/

Hypothesis: An infection, like candida, generates antibodies in the early stages but the autoimmune disease does not develop until a virus cross-targets causing the immune system to malfunction.

For Sjogren's the cross-targeting focus might be T lymphocytes. The infection generating antibodies against the lymphocytes and then the virus infecting the T lymphocyte.

 The resulting inflammation would then be occurring where the candida infections are and the T cells are investigating...the moist areas of the body.  This is just a hypothesis.

Infection: Candida associated with Sjogren's
http://www.ncbi.nlm.nih.gov/pubmed/12973284
http://www.ncbi.nlm.nih.gov/pubmed/21737184 
http://www.medicinaoral.com/pubmed/medoralv15_i2_p310.pdf
http://iadr.confex.com/iadr/2005Balt/techprogram/abstract_63189.htm

overlap of Sjogren's with non-Hodgkin's lymphoma
http://www.ncbi.nlm.nih.gov/pubmed/22198497
http://www.ncbi.nlm.nih.gov/pubmed/22047044

non-Hodgkin's lymphoma with candida
http://www.ncbi.nlm.nih.gov/pubmed/20098335
http://www.ncbi.nlm.nih.gov/pubmed/14650581 
 
anti-nuclear antibodies cross react with lymphocytes
http://www.ncbi.nlm.nih.gov/pubmed/335492
 
So the question is: Does Candida generate anti-nuclear antibodies?  Searching for this now.

Here is a patient with anti-lymphocyte antibodies and a Candida infection
http://www.ncbi.nlm.nih.gov/pubmed/7007634

Lymphocytes grow out of control with Anti-candida antibodies
http://www.ncbi.nlm.nih.gov/pubmed/3531938

So if Candida is the infection that causes the the build up of antibodies in the first stage what virus causes the cross-targeting?

Hepatitis C can infect Lymphocytes
http://www.ncbi.nlm.nih.gov/pubmed/22278227

Virus: hepatits C and Sjogren
http://iadr.confex.com/iadr/2005Balt/techprogram/abstract_63189.htm
http://www.ncbi.nlm.nih.gov/pubmed/10357112
http://www.ncbi.nlm.nih.gov/pubmed/15758837

CMV and Sjogren?
http://www.ncbi.nlm.nih.gov/pubmed/24312567 
http://www.ncbi.nlm.nih.gov/pubmed/18286353

no CMV but epstein-barr?
http://www.ncbi.nlm.nih.gov/pubmed/22332375
http://www.ncbi.nlm.nih.gov/pubmed/12847443


A further interesting thought:

Hypothyroid and Sjogren
http://www.ncbi.nlm.nih.gov/pubmed/17558463
I suspect that fungal infections like aspergillus and candida are linked to hypothyroid (Hashimoto's) with Epstein-barr virus as the cross-targeting trigger.  See newer post with Asperger's overlap.